DNA methyltransferase 3A isoform b contributes to repressing E-cadherin through cooperation of DNA methylation and H3K27/H3K9 methylation in EMT-related metastasis of gastric cancer

DNA methyltransferase 3A (DNMT3A) has been recognised as a key element of epigenetic regulation in normal development, and the aberrant regulation of DNMT3A is implicated in multiple types of cancers, especially haematological malignancies. However, its clinical significance and detailed functional...

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Veröffentlicht in:	Oncogene 2018-08, Vol.37 (32), p.4358-4371
Hauptverfasser:	Cui, He, Hu, Ying, Guo, Didi, Zhang, Aifeng, Gu, Yuejun, Zhang, Shaodan, Zhao, Chengcheng, Gong, Pihai, Shen, Xiaohui, Li, Yiping, Wu, Huazhang, Wang, Ling, Zhao, Zhujiang, Fan, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/105 13/51 13/89 14/19 38/39 631/208/176/1988 631/67/1504/1829 82/29 96/109 Apoptosis Blood cancer Bone morphogenetic proteins Cadherins - genetics Cancer Cancer genetics Cancer metastasis Care and treatment Cell adhesion & migration Cell Biology Cell migration Cell Movement - genetics Complications and side effects Cooperation Criminal investigation Deoxyribonucleic acid DNA DNA (Cytosine-5-)-Methyltransferases - genetics DNA methylation DNA Methylation - genetics DNA methyltransferase E-cadherin Epigenesis, Genetic - genetics Epigenetic inheritance Epigenetics Epithelial-Mesenchymal Transition - genetics Female Gastric cancer Gene expression Gene Expression Regulation, Neoplastic - genetics Gene regulation Genes Genetic aspects Health aspects Histones - genetics Human Genetics Humans Internal Medicine Lymph nodes Lymphatic Metastasis - genetics Male Medicine Medicine & Public Health Mesenchyme Metastases Metastasis Methylation Methyltransferases Middle Aged Oncology Promoter Regions, Genetic - genetics Protein Isoforms - genetics Risk factors Signal transduction Signal Transduction - genetics Snail Family Transcription Factors - genetics Solid tumors Stem cells Stomach cancer Stomach Neoplasms - genetics Stomach Neoplasms - pathology Transcription Transcription (Genetics) Transcription, Genetic - genetics Transferases Transforming Growth Factor beta - genetics Transforming growth factors Tumors
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