Risk factors for loco-regional recurrence in breast cancer patients: a retrospective study

Although fairly uncommon, loco-regional recurrence in breast cancer (BC) has major consequences for the patient. Several predictors for locoregional have been previously reported from large randomized clinical trials mainly from Europe & North America; data from other geographical areas are some...

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Veröffentlicht in:Oncotarget 2018-07, Vol.9 (54), p.30355-30362
Hauptverfasser: Merino, Tomás, Ip, Teresa, Domínguez, Francisco, Acevedo, Francisco, Medina, Lidia, Villaroel, Alejandra, Camus, Mauricio, Vinés, Eugenio, Sánchez, César
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container_end_page 30362
container_issue 54
container_start_page 30355
container_title Oncotarget
container_volume 9
creator Merino, Tomás
Ip, Teresa
Domínguez, Francisco
Acevedo, Francisco
Medina, Lidia
Villaroel, Alejandra
Camus, Mauricio
Vinés, Eugenio
Sánchez, César
description Although fairly uncommon, loco-regional recurrence in breast cancer (BC) has major consequences for the patient. Several predictors for locoregional have been previously reported from large randomized clinical trials mainly from Europe & North America; data from other geographical areas are somewhat scarce. Here we performed a retrospective review of medical records in a single academic center in Chile, searching for predictors of breast tumor recurrence. Median patient follow up was 61 months, 5 year overall survival (OS) rate was 94.2% (95% CI 93-95.3). We found that 108 out of 2,754 (5.3%) patients had loco-regional recurrence. The 2-year loco-regional control was 98% (95% CI 97.3-98.7) and 5-year was 94% (95% CI 92.6-95.4). Univariate analysis showed a correlation between recurrence and being
doi_str_mv 10.18632/oncotarget.25735
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Several predictors for locoregional have been previously reported from large randomized clinical trials mainly from Europe &amp; North America; data from other geographical areas are somewhat scarce. Here we performed a retrospective review of medical records in a single academic center in Chile, searching for predictors of breast tumor recurrence. Median patient follow up was 61 months, 5 year overall survival (OS) rate was 94.2% (95% CI 93-95.3). We found that 108 out of 2,754 (5.3%) patients had loco-regional recurrence. The 2-year loco-regional control was 98% (95% CI 97.3-98.7) and 5-year was 94% (95% CI 92.6-95.4). Univariate analysis showed a correlation between recurrence and being &lt;50 year-old, positive surgical margins, advanced stage, subtype, and presence of LVI and omission of adjuvant radiotherapy. Only the absence of adjuvant RT was predictor of locoregional recurrence in multivariable ( 0.001). Our study population presents high local control of BC. Age, surgical margins, stage, molecular subtype and absence of adjuvant radiotherapy were associated with loco-regional recurrence. Prospective trials and long-term follow up are required in order to confirm these results. We analyzed medical records from 2,201 BC patients at the Pontificia Universidad Católica de Chile from 1997 to 2016. 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Age, surgical margins, stage, molecular subtype and absence of adjuvant radiotherapy were associated with loco-regional recurrence. Prospective trials and long-term follow up are required in order to confirm these results. We analyzed medical records from 2,201 BC patients at the Pontificia Universidad Católica de Chile from 1997 to 2016. Collected data included: age at diagnosis, tumor size, axillary involvement, molecular subtype, margin status, histological grade, lympho-vascular invasion (LVI) and ipsilateral recurrence.</abstract><cop>United States</cop><pub>Impact Journals LLC</pub><pmid>30100994</pmid><doi>10.18632/oncotarget.25735</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
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title Risk factors for loco-regional recurrence in breast cancer patients: a retrospective study
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