Improved disease activity with fosdagrocorat (PF‐04171327), a partial agonist of the glucocorticoid receptor, in patients with rheumatoid arthritis: a Phase 2 randomized study

Aim To assess efficacy and safety of fosdagrocorat (PF‐04171327), a potential dissociated agonist of the glucocorticoid receptor, in rheumatoid arthritis (RA) patients. Methods This multicenter, double‐blind, parallel‐group, active‐ and placebo‐controlled Phase 2 study (NCT00938587) randomized 86 pa...

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Veröffentlicht in:	International journal of rheumatic diseases 2017-08, Vol.20 (8), p.960-970
Hauptverfasser:	Stock, Thomas, Fleishaker, Dona, Wang, Xin, Mukherjee, Arnab, Mebus, Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antirheumatic Agents - administration & dosage Antirheumatic Agents - adverse effects Antirheumatic Agents - pharmacokinetics arthritis Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - diagnosis Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - physiopathology Biomarkers - blood C-reactive protein C-Reactive Protein - metabolism Disability Evaluation Double-Blind Method Drug Partial Agonism Drug Therapy, Combination Female Glucocorticoids Glucocorticoids - administration & dosage Health risk assessment Humans Hydrocortisone - blood Joint diseases Joints - drug effects Joints - metabolism Joints - physiopathology Male Methotrexate Methotrexate - administration & dosage Middle Aged Organophosphates - administration & dosage Organophosphates - adverse effects Organophosphates - pharmacokinetics Original Phenanthrenes - administration & dosage Phenanthrenes - adverse effects Phenanthrenes - pharmacokinetics Prednisone Prednisone - administration & dosage randomized controlled trial Receptors, Glucocorticoid - agonists Receptors, Glucocorticoid - metabolism Recovery of Function rheumatoid Rheumatoid arthritis Severity of Illness Index Surveys and Questionnaires Time Factors Treatment Outcome
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