Downregulation of CYP2A6 and CYP2C8 in Tumor Tissues Is Linked to Worse Overall Survival and Recurrence-Free Survival from Hepatocellular Carcinoma

Objective. This study aimed to evaluate the links between CYP450 family genes in tumor tissues and hepatocellular carcinoma (HCC) outcomes. Methods. Gene Expression Omnibus (GEO) databases GSE14520 and GSE36376 were used to identify differential expressed CYP450 genes between tumor and nontumor tiss...

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Veröffentlicht in:	BioMed research international 2018-01, Vol.2018 (2018), p.1-9
Hauptverfasser:	Qi, Xun, Jiang, Xuhua, Ji, Yuanyuan, Ren, Xiaojing
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Breast cancer Cancer therapies Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - mortality CYP1A2 protein Cytochrome Cytochrome P-450 Cytochrome P-450 CYP2A6 - metabolism Cytochrome P-450 CYP2C8 - metabolism Cytochrome P450 Disease-Free Survival Diseases Down-Regulation Enzymes Gene expression Genes Genetic aspects Genomics Hepatocellular carcinoma Hepatoma Humans Liver cancer Liver Neoplasms - metabolism Liver Neoplasms - mortality Lung cancer Medical imaging Medical prognosis Medical research Metabolism Metabolites Metastases Neoplasm Staging NMR Nuclear magnetic resonance Patient outcomes Patients Polymorphism Prognosis Relapse Republic of Korea Surgery Survival Tissues Tumor staging Tumors
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