Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo

High-throughput mapping of cellular differentiation hierarchies from single-cell data promises to empower systematic interrogations of vertebrate development and disease. Here we applied single-cell RNA sequencing to >92,000 cells from zebrafish embryos during the first day of development. Using...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2018-06, Vol.360 (6392), p.981-987
Hauptverfasser:	Wagner, Daniel E, Weinreb, Caleb, Collins, Zach M, Briggs, James A, Megason, Sean G, Klein, Allon M
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell lineage Chordin Chordin gene Computer applications Danio rerio Differentiation (biology) Embryos Gene expression Gene mapping Gene sequencing Hierarchies Individualized Instruction Mapping Organogenesis Pattern formation Pluripotency Ribonucleic acid RNA Trajectories Transcription Zebrafish
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