Biodegradable PEG-poly(ω-pentadecalactone-co-p-dioxanone) nanoparticles for enhanced and sustained drug delivery to treat brain tumors

Intracranial delivery of therapeutic agents is limited by penetration beyond the blood-brain barrier (BBB) and rapid metabolism of the drugs that are delivered. Convection-enhanced delivery (CED) of drug-loaded nanoparticles (NPs) provides for local administration, control of distribution, and susta...

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Veröffentlicht in:	Biomaterials 2018-09, Vol.178, p.193-203
Hauptverfasser:	Chen, Evan M, Quijano, Amanda R, Seo, Young-Eun, Jackson, Christopher, Josowitz, Alexander D, Noorbakhsh, Seth, Merlettini, Andrea, Sundaram, Ranjini K, Focarete, Maria Letizia, Jiang, Zhaozhong, Bindra, Ranjit S, Saltzman, W Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatible Materials - chemistry Brain Neoplasms - drug therapy Brain Neoplasms - pathology Convection Drug Delivery Systems Drug Liberation Hydrodynamics Isoxazoles - pharmacology Male Nanoparticles - chemistry Nanoparticles - ultrastructure Polyesters - chemical synthesis Polyesters - chemistry Polyethylene Glycols - chemical synthesis Polyethylene Glycols - chemistry Pyrazines - pharmacology Radiation-Sensitizing Agents - pharmacology Rats, Inbred F344 Xenograft Model Antitumor Assays
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