Exosomal αvβ6 integrin is required for monocyte M2 polarization in prostate cancer

Therapeutic approaches aimed at curing prostate cancer are only partially successful given the occurrence of highly metastatic resistant phenotypes that frequently develop in response to therapies. Recently, we have described αvβ6, a surface receptor of the integrin family as a novel therapeutic tar...

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Veröffentlicht in:	Matrix biology 2018-09, Vol.70, p.20-35
Hauptverfasser:	Lu, Huimin, Bowler, Nicholas, Harshyne, Larry A., Craig Hooper, D., Krishn, Shiv Ram, Kurtoglu, Senem, Fedele, Carmine, Liu, Qin, Tang, Hsin-Yao, Kossenkov, Andrew V., Kelly, William K., Wang, Kerith, Kean, Rhonda B., Weinreb, Paul H., Yu, Lei, Dutta, Anindita, Fortina, Paolo, Ertel, Adam, Stanczak, Maria, Forsberg, Flemming, Gabrilovich, Dmitry I., Speicher, David W., Altieri, Dario C., Languino, Lucia R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - immunology Adenocarcinoma - pathology Animals Antibodies, Monoclonal - pharmacology Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology Antineoplastic Agents, Immunological - pharmacology Cell Communication Cell Differentiation Coculture Techniques Exosomes Exosomes - metabolism Exosomes - pathology Gene Expression Regulation, Neoplastic Humans Integrins - antagonists & inhibitors Integrins - genetics Integrins - immunology Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - immunology M2 polarization Male Mice Mice, Knockout Monocytes Myxovirus Resistance Proteins - genetics Myxovirus Resistance Proteins - immunology PC-3 Cells Primary Cell Culture Prostate Cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - immunology Prostatic Neoplasms - pathology PTEN Phosphohydrolase - deficiency PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - immunology Signal Transduction STAT1 STAT1 Transcription Factor - genetics STAT1 Transcription Factor - immunology THP-1 Cells Tumor Burden - drug effects Xenograft Model Antitumor Assays αvβ6 integrin
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