BDNF rescues prefrontal dysfunction elicited by pyramidal neuron-specific DTNBP1 deletion in vivo

Dystrobrevin-binding protein 1 （Dtnbp1） is one of the earliest identified schizophrenia susceptibility genes. Reduced expression of DTNBP1 is commonly found in brain areas of schizophrenic patients. Dtnbp1-nuU mutant mice exhibit abnormalities in beha- viors and impairments in neuronal activities. H...

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Veröffentlicht in:	Journal of molecular cell biology 2017-04, Vol.9 (2), p.117-131
Hauptverfasser:	Zhang, Wen, Daly, Kathryn M, Liang, Bo, Zhang, Lifeng, Li, Xuan, Li, Yun, Lin, Da-Ting
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BDNF Behavior, Animal Brain-Derived Neurotrophic Factor - metabolism Dependovirus Dysbindin Dystrophin-Associated Proteins - metabolism Excitatory Postsynaptic Potentials gamma-Aminobutyric Acid - metabolism Gene Deletion Green Fluorescent Proteins - metabolism Inhibitory Postsynaptic Potentials Integrases - metabolism Male Mice Organ Specificity Original Prefrontal Cortex - physiopathology Prepulse Inhibition Pyramidal Cells - metabolism 体内前额叶皮质功能障碍救援精神分裂症脑源性神经营养因子锥体神经元
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