The Effect of MitoQ on Aging-Related Biomarkers: A Systematic Review and Meta-Analysis
Mitochondria are metabolically active organelles that produce significant reactive oxygen species, linked with aging and degenerative diseases. In recent years, particular focus has been put on mitochondria-targeted antioxidants, to decrease the concentration of reactive oxygen species and help alle...
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| description | Mitochondria are metabolically active organelles that produce significant reactive oxygen species, linked with aging and degenerative diseases. In recent years, particular focus has been put on mitochondria-targeted antioxidants, to decrease the concentration of reactive oxygen species and help alleviate the accumulation of oxidative damage and associated aging. MitoQ is a mitochondria-targeted antioxidant of which is reported to support healthy aging. The aim of this systematic review is to investigate the effects of MitoQ on oxidative outcomes related to the aging process. A predeveloped search strategy was run against MEDLINE (Ovid), EMBASE (Ovid), and CINAHL databases, which identified 10,255 articles of interest, with 27 of these finalised for use after screening. Three outcomes had sufficient data to meta-analyse nitrotyrosine concentration (190 animals, SMD −0.67, 95% CI (−1.30, −0.05), p=0.04), membrane potential (63 animals, MD 11.44, 95% CI (1.28–21.60), p=0.03), and protein carbonyl concentration (182 animals, SMD −0.13, 95% CI (−0.44, 0.18), p=0.41). MitoQ intervention produced a statistically significant reduction in nitrotyrosine concentration and increased membrane potential. MitoQ may be of some benefit in alleviating oxidative stress related to aging. |
| doi_str_mv | 10.1155/2018/8575263 |
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In recent years, particular focus has been put on mitochondria-targeted antioxidants, to decrease the concentration of reactive oxygen species and help alleviate the accumulation of oxidative damage and associated aging. MitoQ is a mitochondria-targeted antioxidant of which is reported to support healthy aging. The aim of this systematic review is to investigate the effects of MitoQ on oxidative outcomes related to the aging process. A predeveloped search strategy was run against MEDLINE (Ovid), EMBASE (Ovid), and CINAHL databases, which identified 10,255 articles of interest, with 27 of these finalised for use after screening. Three outcomes had sufficient data to meta-analyse nitrotyrosine concentration (190 animals, SMD −0.67, 95% CI (−1.30, −0.05), p=0.04), membrane potential (63 animals, MD 11.44, 95% CI (1.28–21.60), p=0.03), and protein carbonyl concentration (182 animals, SMD −0.13, 95% CI (−0.44, 0.18), p=0.41). MitoQ intervention produced a statistically significant reduction in nitrotyrosine concentration and increased membrane potential. MitoQ may be of some benefit in alleviating oxidative stress related to aging.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2018/8575263</identifier><identifier>PMID: 30116495</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Aging ; Analysis ; Antioxidants ; Bioenergetics ; Biology ; Biomarkers ; Biomarkers - metabolism ; Deoxyribonucleic acid ; DNA ; Enzymes ; Free radicals ; Humans ; Lipid peroxidation ; Lipids ; Medical Subject Headings-MeSH ; Meta-analysis ; Mitochondria ; Mitochondria - metabolism ; Organophosphorus Compounds - pharmacology ; Organophosphorus Compounds - therapeutic use ; Otology ; Oxidation ; Oxidative stress ; Phosphorylation ; Physiology ; Proteins ; Reactive oxygen species ; Review ; Smith, A J ; Studies ; Systematic review ; Ubiquinone - analogs & derivatives ; Ubiquinone - pharmacology ; Ubiquinone - therapeutic use</subject><ispartof>Oxidative medicine and cellular longevity, 2018-01, Vol.2018 (2018), p.1-12</ispartof><rights>Copyright © 2018 Andrea J. Braakhuis et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Andrea J. Braakhuis et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2018 Andrea J. 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In recent years, particular focus has been put on mitochondria-targeted antioxidants, to decrease the concentration of reactive oxygen species and help alleviate the accumulation of oxidative damage and associated aging. MitoQ is a mitochondria-targeted antioxidant of which is reported to support healthy aging. The aim of this systematic review is to investigate the effects of MitoQ on oxidative outcomes related to the aging process. A predeveloped search strategy was run against MEDLINE (Ovid), EMBASE (Ovid), and CINAHL databases, which identified 10,255 articles of interest, with 27 of these finalised for use after screening. Three outcomes had sufficient data to meta-analyse nitrotyrosine concentration (190 animals, SMD −0.67, 95% CI (−1.30, −0.05), p=0.04), membrane potential (63 animals, MD 11.44, 95% CI (1.28–21.60), p=0.03), and protein carbonyl concentration (182 animals, SMD −0.13, 95% CI (−0.44, 0.18), p=0.41). MitoQ intervention produced a statistically significant reduction in nitrotyrosine concentration and increased membrane potential. MitoQ may be of some benefit in alleviating oxidative stress related to aging.</description><subject>Aging</subject><subject>Analysis</subject><subject>Antioxidants</subject><subject>Bioenergetics</subject><subject>Biology</subject><subject>Biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Enzymes</subject><subject>Free radicals</subject><subject>Humans</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Medical Subject Headings-MeSH</subject><subject>Meta-analysis</subject><subject>Mitochondria</subject><subject>Mitochondria - metabolism</subject><subject>Organophosphorus Compounds - pharmacology</subject><subject>Organophosphorus Compounds - therapeutic use</subject><subject>Otology</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Phosphorylation</subject><subject>Physiology</subject><subject>Proteins</subject><subject>Reactive oxygen species</subject><subject>Review</subject><subject>Smith, A J</subject><subject>Studies</subject><subject>Systematic review</subject><subject>Ubiquinone - analogs & derivatives</subject><subject>Ubiquinone - pharmacology</subject><subject>Ubiquinone - therapeutic use</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkc1v1DAQxSMEoh9w44wscalU0o4_4sQ9IKVVgUqtEGXF1XKS8a5L1i5xttX-9zjaZQucOM1I89N7b_Sy7A2FE0qL4pQBrU6roiyY5M-yfaoEy0Ep8Xy3A-xlBzHeAUjOBH2Z7XGgVApV7GffZwskl9ZiO5JgyY0bw1cSPKnnzs_zW-zNiB05d2Fphh84xDNSk2_rOOLSjK4lt_jg8JEY35EbHE1ee9Ovo4uvshfW9BFfb-dhNvt4Obv4nF9_-XR1UV_nrVBqzGWFVdEoYQU2VVcVBRqmABW1kinOOLdN01nDrWJNxUFCC4KrRrRUKi4afph92Mjer5oldi36cTC9vh9cirvWwTj998W7hZ6HBy2hVAIgCRxtBYbwc4Vx1EsXW-x74zGsomZQqRSrBJ7Qd_-gd2E1pH8nqhSgyrKUT9Tc9KidtyH5tpOoriWwkpaCT7bvN1Q7hBgHtLvIFPTUqp5a1dtWE_72zzd38O8aE3C8ARbOd-bR_adcKjF5myeaUZYi8l-1e7EG</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Braakhuis, Andrea J.</creator><creator>Somerville, Vaughan</creator><creator>Nagulan, Rohith</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6055-0595</orcidid></search><sort><creationdate>20180101</creationdate><title>The Effect of MitoQ on Aging-Related Biomarkers: A Systematic Review and Meta-Analysis</title><author>Braakhuis, Andrea J. ; 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In recent years, particular focus has been put on mitochondria-targeted antioxidants, to decrease the concentration of reactive oxygen species and help alleviate the accumulation of oxidative damage and associated aging. MitoQ is a mitochondria-targeted antioxidant of which is reported to support healthy aging. The aim of this systematic review is to investigate the effects of MitoQ on oxidative outcomes related to the aging process. A predeveloped search strategy was run against MEDLINE (Ovid), EMBASE (Ovid), and CINAHL databases, which identified 10,255 articles of interest, with 27 of these finalised for use after screening. Three outcomes had sufficient data to meta-analyse nitrotyrosine concentration (190 animals, SMD −0.67, 95% CI (−1.30, −0.05), p=0.04), membrane potential (63 animals, MD 11.44, 95% CI (1.28–21.60), p=0.03), and protein carbonyl concentration (182 animals, SMD −0.13, 95% CI (−0.44, 0.18), p=0.41). MitoQ intervention produced a statistically significant reduction in nitrotyrosine concentration and increased membrane potential. MitoQ may be of some benefit in alleviating oxidative stress related to aging.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>30116495</pmid><doi>10.1155/2018/8575263</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-6055-0595</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aging Analysis Antioxidants Bioenergetics Biology Biomarkers Biomarkers - metabolism Deoxyribonucleic acid DNA Enzymes Free radicals Humans Lipid peroxidation Lipids Medical Subject Headings-MeSH Meta-analysis Mitochondria Mitochondria - metabolism Organophosphorus Compounds - pharmacology Organophosphorus Compounds - therapeutic use Otology Oxidation Oxidative stress Phosphorylation Physiology Proteins Reactive oxygen species Review Smith, A J Studies Systematic review Ubiquinone - analogs & derivatives Ubiquinone - pharmacology Ubiquinone - therapeutic use |
| title | The Effect of MitoQ on Aging-Related Biomarkers: A Systematic Review and Meta-Analysis |
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