Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease

The purpose of our study was to understand the protective effects of reduced expression of dynamin-related protein (Drp1) against amyloid beta (Aβ) induced mitochondrial and synaptic toxicities in Alzheimer's disease (AD) progression and pathogenesis. Our recent molecular and biochemical studie...

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Veröffentlicht in:	Human molecular genetics 2016-12, Vol.25 (23), p.5148-5166
Hauptverfasser:	Manczak, Maria, Kandimalla, Ramesh, Fry, David, Sesaki, Hiromi, Reddy, P Hemachandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - genetics Alzheimer Disease - pathology Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Animals Brain - metabolism Brain - pathology Disease Models, Animal Dynamins - antagonists & inhibitors Dynamins - genetics Humans Mice Mice, Transgenic Mitochondria - genetics Mitochondria - pathology Mitochondrial Dynamics - drug effects Molecular Targeted Therapy Neurons - metabolism Neurons - pathology Synapses - drug effects Synapses - pathology
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