Plastic change of prefrontal cortex mediates anxiety-like behaviors associated with chronic pain in neuropathic rats

Clinical studies show that anxiety and chronic pain are concomitant. The neural basis for the comorbidity is unclear. The prefrontal cortex (PFC) has been recognized as a critical area for affective disorders and chronic pain modulation. In this study, we examined the role of the PFC in the pathogen...

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Veröffentlicht in:	Molecular pain 2018-01, Vol.14, p.1744806918783931-1744806918783931
Hauptverfasser:	Sang, Kangning, Bao, Chaofei, Xin, Yushi, Hu, Shunan, Gao, Xian, Wang, Yongsheng, Bodner, Mark, Zhou, Yong-Di, Dong, Xiao-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Affective disorders Anxiety Chronic pain Citalopram Hippocampus Motor activity Neuralgia Neuroplasticity Open-field behavior Pain Prefrontal cortex Serotonin Serotonin transporter Synchronization Theta rhythms
Online-Zugang:	Volltext
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