Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy

Endocrine therapy resistance invariably develops in advanced estrogen receptor-positive (ER⁺) breast cancer, but the underlying mechanisms are largely unknown. We have identified C-terminal SRC kinase (CSK) as a critical node in a previously unappreciated negative feedback loop that limits the effic...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2018-07, Vol.115 (31), p.7869-7878
Hauptverfasser:	Xiao, Tengfei, Li, Wei, Wang, Xiaoqing, Xu, Han, Yang, Jixin, Wu, Qiu, Huang, Ying, Geradts, Joseph, Jiang, Peng, Fei, Teng, Chi, David, Zang, Chongzhi, Liao, Qi, Rennhack, Jonathan, Andrechek, Eran, Li, Nanlin, Detre, Simone, Dowsett, Mitchell, Jeselsohn, Rinath M., Liu, Shirley, Brown, Myles
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cancer therapies Endocrine therapy Estrogen receptors Estrogens Estrogens - pharmacology Feedback Feedback loops Female Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Neoplastic - drug effects GTP-binding protein Humans INAUGURAL ARTICLE Kinases MCF-7 Cells Negative feedback Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics p21-Activated Kinases - biosynthesis p21-Activated Kinases - genetics Proteins Receptors, Estrogen - biosynthesis Receptors, Estrogen - genetics src-Family Kinases - biosynthesis src-Family Kinases - genetics Therapy Tumors
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