Effects of Juniperus phoenicea Hydroalcoholic Extract on Inflammatory Mediators and Oxidative Stress Markers in Carrageenan-Induced Paw Oedema in Mice
Juniperus phoenicea (J. phoenicea) is a wild tree belonging to the Cupressaceae family, commonly used for the treatment of several disorders. This study aimed to evaluate the potential protective effects of J. phoenicea hydroethanolic extract (EtOH-H2OE) against oxidation, acute inflammation, and pa...
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| description | Juniperus phoenicea (J. phoenicea) is a wild tree belonging to the Cupressaceae family, commonly used for the treatment of several disorders. This study aimed to evaluate the potential protective effects of J. phoenicea hydroethanolic extract (EtOH-H2OE) against oxidation, acute inflammation, and pain in mice models. For the purpose, chemical compounds of J. phoenicea EtOH-H2OE were also analyzed by GC-MS. The J. phoenicea EtOH-H2OE showed a potent antioxidant activity in vitro, thanks to its richness in phenolic and flavonoid compounds. Mice treated with EtOH-H2OE (100 mg/kg BW) showed reduced paw oedema formation and decreased malondialdehyde (MDA) content. The evaluation of antioxidant enzyme activities in paw oedema tissue after five hours of carrageenan induction showed a significant increase (P |
| doi_str_mv | 10.1155/2018/3785487 |
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This study aimed to evaluate the potential protective effects of J. phoenicea hydroethanolic extract (EtOH-H2OE) against oxidation, acute inflammation, and pain in mice models. For the purpose, chemical compounds of J. phoenicea EtOH-H2OE were also analyzed by GC-MS. The J. phoenicea EtOH-H2OE showed a potent antioxidant activity in vitro, thanks to its richness in phenolic and flavonoid compounds. Mice treated with EtOH-H2OE (100 mg/kg BW) showed reduced paw oedema formation and decreased malondialdehyde (MDA) content. The evaluation of antioxidant enzyme activities in paw oedema tissue after five hours of carrageenan induction showed a significant increase (P<0.05). Inflammatory biomarkers explorations of J. phoenicea EtOH-H2OE-treated mice showed a restoration of the studied parameters to near-normal values. Furthermore, EtOH-H2OE of J. phoenicea produced a significant reduction of the number of abdominal writhes (P<0.05) in a dose-dependent way. Phytochemical analysis of the J. phoenicea EtOH-H2OE by GC-MS showed the presence of hexadecanoic and stearic acids known as anti-inflammatory and analgesic compounds. Our investigation provided evidence that J. phoenicea EtOH-H2OE can effectively reduce the inflammation and pain in mice models.</description><identifier>ISSN: 2314-6133</identifier><identifier>ISSN: 2314-6141</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2018/3785487</identifier><identifier>PMID: 30112384</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Analgesics ; Animal models ; Animals ; Anti-Inflammatory Agents ; Antioxidants ; Bioflavonoids ; Biomarkers ; Carrageenan ; Carrageenin ; Cell adhesion & migration ; Chemical compounds ; Cupressaceae ; Cytokines ; Dropsy ; Edema ; Edema - drug therapy ; Enzymatic activity ; Enzymes ; Flavones ; Flavonoids ; Herbal medicine ; Inflammation ; Inflammation - drug therapy ; Inflammation Mediators ; Juniperus - chemistry ; Juniperus phoenicea ; Leaves ; Malondialdehyde ; Medical research ; Medicine, Experimental ; Mice ; Natural products ; Organic chemistry ; Oxidation ; Oxidative stress ; Oxidative Stress - drug effects ; Pain ; Pain - drug therapy ; Phenolic compounds ; Phenols ; Phytochemicals ; Plant Extracts - pharmacology</subject><ispartof>BioMed research international, 2018-01, Vol.2018 (2018), p.1-11</ispartof><rights>Copyright © 2018 Karama Zouari Bouassida et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Karama Zouari Bouassida et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2018 Karama Zouari Bouassida et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-9af781b1165e96d1fd390cf379edd576fbe145214a17fca329e0bcb9a0a3aa2f3</citedby><cites>FETCH-LOGICAL-c499t-9af781b1165e96d1fd390cf379edd576fbe145214a17fca329e0bcb9a0a3aa2f3</cites><orcidid>0000-0002-1545-0122 ; 0000-0002-3297-0293 ; 0000-0002-3036-6877</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077615/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6077615/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30112384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Jadeja, Ravirajsinh N.</contributor><contributor>Ravirajsinh N Jadeja</contributor><creatorcontrib>Trigui, Mohamed</creatorcontrib><creatorcontrib>Jlaiel, Lobna</creatorcontrib><creatorcontrib>Tounsi, Amina</creatorcontrib><creatorcontrib>Makni, Samar</creatorcontrib><creatorcontrib>Zouari Bouassida, Karama</creatorcontrib><creatorcontrib>Tounsi, S.</creatorcontrib><title>Effects of Juniperus phoenicea Hydroalcoholic Extract on Inflammatory Mediators and Oxidative Stress Markers in Carrageenan-Induced Paw Oedema in Mice</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Juniperus phoenicea (J. phoenicea) is a wild tree belonging to the Cupressaceae family, commonly used for the treatment of several disorders. This study aimed to evaluate the potential protective effects of J. phoenicea hydroethanolic extract (EtOH-H2OE) against oxidation, acute inflammation, and pain in mice models. For the purpose, chemical compounds of J. phoenicea EtOH-H2OE were also analyzed by GC-MS. The J. phoenicea EtOH-H2OE showed a potent antioxidant activity in vitro, thanks to its richness in phenolic and flavonoid compounds. Mice treated with EtOH-H2OE (100 mg/kg BW) showed reduced paw oedema formation and decreased malondialdehyde (MDA) content. The evaluation of antioxidant enzyme activities in paw oedema tissue after five hours of carrageenan induction showed a significant increase (P<0.05). Inflammatory biomarkers explorations of J. phoenicea EtOH-H2OE-treated mice showed a restoration of the studied parameters to near-normal values. Furthermore, EtOH-H2OE of J. phoenicea produced a significant reduction of the number of abdominal writhes (P<0.05) in a dose-dependent way. Phytochemical analysis of the J. phoenicea EtOH-H2OE by GC-MS showed the presence of hexadecanoic and stearic acids known as anti-inflammatory and analgesic compounds. Our investigation provided evidence that J. phoenicea EtOH-H2OE can effectively reduce the inflammation and pain in mice models.</description><subject>Analgesics</subject><subject>Animal models</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents</subject><subject>Antioxidants</subject><subject>Bioflavonoids</subject><subject>Biomarkers</subject><subject>Carrageenan</subject><subject>Carrageenin</subject><subject>Cell adhesion & migration</subject><subject>Chemical compounds</subject><subject>Cupressaceae</subject><subject>Cytokines</subject><subject>Dropsy</subject><subject>Edema</subject><subject>Edema - drug therapy</subject><subject>Enzymatic activity</subject><subject>Enzymes</subject><subject>Flavones</subject><subject>Flavonoids</subject><subject>Herbal medicine</subject><subject>Inflammation</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation Mediators</subject><subject>Juniperus - chemistry</subject><subject>Juniperus phoenicea</subject><subject>Leaves</subject><subject>Malondialdehyde</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mice</subject><subject>Natural products</subject><subject>Organic chemistry</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trigui, Mohamed</au><au>Jlaiel, Lobna</au><au>Tounsi, Amina</au><au>Makni, Samar</au><au>Zouari Bouassida, Karama</au><au>Tounsi, S.</au><au>Jadeja, Ravirajsinh N.</au><au>Ravirajsinh N Jadeja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Juniperus phoenicea Hydroalcoholic Extract on Inflammatory Mediators and Oxidative Stress Markers in Carrageenan-Induced Paw Oedema in Mice</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>11</epage><pages>1-11</pages><issn>2314-6133</issn><issn>2314-6141</issn><eissn>2314-6141</eissn><abstract>Juniperus phoenicea (J. phoenicea) is a wild tree belonging to the Cupressaceae family, commonly used for the treatment of several disorders. This study aimed to evaluate the potential protective effects of J. phoenicea hydroethanolic extract (EtOH-H2OE) against oxidation, acute inflammation, and pain in mice models. For the purpose, chemical compounds of J. phoenicea EtOH-H2OE were also analyzed by GC-MS. The J. phoenicea EtOH-H2OE showed a potent antioxidant activity in vitro, thanks to its richness in phenolic and flavonoid compounds. Mice treated with EtOH-H2OE (100 mg/kg BW) showed reduced paw oedema formation and decreased malondialdehyde (MDA) content. The evaluation of antioxidant enzyme activities in paw oedema tissue after five hours of carrageenan induction showed a significant increase (P<0.05). Inflammatory biomarkers explorations of J. phoenicea EtOH-H2OE-treated mice showed a restoration of the studied parameters to near-normal values. Furthermore, EtOH-H2OE of J. phoenicea produced a significant reduction of the number of abdominal writhes (P<0.05) in a dose-dependent way. Phytochemical analysis of the J. phoenicea EtOH-H2OE by GC-MS showed the presence of hexadecanoic and stearic acids known as anti-inflammatory and analgesic compounds. Our investigation provided evidence that J. phoenicea EtOH-H2OE can effectively reduce the inflammation and pain in mice models.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>30112384</pmid><doi>10.1155/2018/3785487</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-1545-0122</orcidid><orcidid>https://orcid.org/0000-0002-3297-0293</orcidid><orcidid>https://orcid.org/0000-0002-3036-6877</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Analgesics Animal models Animals Anti-Inflammatory Agents Antioxidants Bioflavonoids Biomarkers Carrageenan Carrageenin Cell adhesion & migration Chemical compounds Cupressaceae Cytokines Dropsy Edema Edema - drug therapy Enzymatic activity Enzymes Flavones Flavonoids Herbal medicine Inflammation Inflammation - drug therapy Inflammation Mediators Juniperus - chemistry Juniperus phoenicea Leaves Malondialdehyde Medical research Medicine, Experimental Mice Natural products Organic chemistry Oxidation Oxidative stress Oxidative Stress - drug effects Pain Pain - drug therapy Phenolic compounds Phenols Phytochemicals Plant Extracts - pharmacology |
| title | Effects of Juniperus phoenicea Hydroalcoholic Extract on Inflammatory Mediators and Oxidative Stress Markers in Carrageenan-Induced Paw Oedema in Mice |
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