Long-term outcomes and prognostic markers in gallbladder cancer
Cancer-related inflammation and systemic inflammatory markers have been widely recognized as an essential part in tumor multiplication, invasion, and metastasis of tumor cells. This study aimed to estimate and compare the prognostic value of various biomarkers on overall survival (OS) in patients wi...
Gespeichert in:
| Veröffentlicht in: | Medicine (Baltimore) 2018-07, Vol.97 (28), p.e11396-e11396 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e11396 |
|---|---|
| container_issue | 28 |
| container_start_page | e11396 |
| container_title | Medicine (Baltimore) |
| container_volume | 97 |
| creator | Cui, Xiwei Zhu, Sha Tao, Zhihang Deng, Xinghao Wang, Yexiao Gao, Yuanjing Liao, Yue Ma, Weijun Zhang, Yiwen Ma, Xuelei |
| description | Cancer-related inflammation and systemic inflammatory markers have been widely recognized as an essential part in tumor multiplication, invasion, and metastasis of tumor cells. This study aimed to estimate and compare the prognostic value of various biomarkers on overall survival (OS) in patients with gallbladder cancer patients.We performed a retrospective study of 159 patients received different therapies in West China Hospital from 2009 to 2014. The preoperative biomarker data, including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), lactate dehydrogenase, and alkaline phosphatase, as well as other clinical information, were obtained from electronic record. And the receiver operating characteristic curves were used to analyze the optimal cut-off values of them. Kaplan-Meier survival analysis and Cox proportional hazard model analysis were applied to evaluate the association between markers and OS.The optimal cut-off value was 4.39 for NLR, 181.85 for PLR, 0.30 for MLR, and 3.02 for carcinoembryonic antigen (CEA). Kaplan-Meier analysis and univariate Cox analysis both demonstrated the significant prognostic value of NLR, MLR, and CEA. However, PLR failed to be a significant predictor of OS. The multivariate Cox analysis showed that preoperative NLR and CEA were independent prognostic factors for OS.Advanced tumor/node/metastasis stage, enhanced pretherapeutic NLR, and CEA were significantly associated with worse OS of gallbladder cancer patients. Furthermore, NLR was a better prognostic factor than CEA in advanced T (T3-T4) stage patients, while CEA was better for early T (T1-T2) stage, early N (N0-N1) stage, and early M (M0) stage patients. |
| doi_str_mv | 10.1097/MD.0000000000011396 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6076111</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2068911106</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4504-14d5448920533905490cb3a47d5d07ad38b3c06a2193a7b335ee8a6b364c5a9e3</originalsourceid><addsrcrecordid>eNpdkE1v1DAQhi0EotuFX4CEcuSSMs74I76AUAsFaate4Gw5znQ31IkXO6Hi39ewpZT6MpLnmXdGD2OvOJxwMPrtxdkJ_Huco1FP2IpLVLU0SjxlK4BG1tpoccSOc_5eINSNeM6OGmOM1C2u2PtNnLb1TGms4jL7OFKu3NRX-xS3U8zz4KvRpWtKuRqmautC6ILre0qVd5On9II9u3Ih08u7umbfPn38evq53lyefzn9sKm9kCBqLnopRGsakIgGpDDgO3RC97IH7XpsO_SgXMMNOt0hSqLWqQ6V8NIZwjV7d8jdL91IvadpTi7YfRrKeb9sdIP9vzMNO7uNP60CrXiRs2Zv7gJS_LFQnu04ZE8huInikm0DqjUFBFVQPKA-xZwTXd2v4WB_q7cXZ_ax-jL1-uGF9zN_XRdAHICbGIrwfB2WG0p2Ry7Muz95UpumboC3oDlCXX5Q4C2lBI4o</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2068911106</pqid></control><display><type>article</type><title>Long-term outcomes and prognostic markers in gallbladder cancer</title><source>IngentaConnect</source><source>MEDLINE</source><source>PubMed Central</source><source>Directory of Open Access Journals</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><source>Wolters Kluwer Open Access</source><creator>Cui, Xiwei ; Zhu, Sha ; Tao, Zhihang ; Deng, Xinghao ; Wang, Yexiao ; Gao, Yuanjing ; Liao, Yue ; Ma, Weijun ; Zhang, Yiwen ; Ma, Xuelei</creator><creatorcontrib>Cui, Xiwei ; Zhu, Sha ; Tao, Zhihang ; Deng, Xinghao ; Wang, Yexiao ; Gao, Yuanjing ; Liao, Yue ; Ma, Weijun ; Zhang, Yiwen ; Ma, Xuelei</creatorcontrib><description>Cancer-related inflammation and systemic inflammatory markers have been widely recognized as an essential part in tumor multiplication, invasion, and metastasis of tumor cells. This study aimed to estimate and compare the prognostic value of various biomarkers on overall survival (OS) in patients with gallbladder cancer patients.We performed a retrospective study of 159 patients received different therapies in West China Hospital from 2009 to 2014. The preoperative biomarker data, including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), lactate dehydrogenase, and alkaline phosphatase, as well as other clinical information, were obtained from electronic record. And the receiver operating characteristic curves were used to analyze the optimal cut-off values of them. Kaplan-Meier survival analysis and Cox proportional hazard model analysis were applied to evaluate the association between markers and OS.The optimal cut-off value was 4.39 for NLR, 181.85 for PLR, 0.30 for MLR, and 3.02 for carcinoembryonic antigen (CEA). Kaplan-Meier analysis and univariate Cox analysis both demonstrated the significant prognostic value of NLR, MLR, and CEA. However, PLR failed to be a significant predictor of OS. The multivariate Cox analysis showed that preoperative NLR and CEA were independent prognostic factors for OS.Advanced tumor/node/metastasis stage, enhanced pretherapeutic NLR, and CEA were significantly associated with worse OS of gallbladder cancer patients. Furthermore, NLR was a better prognostic factor than CEA in advanced T (T3-T4) stage patients, while CEA was better for early T (T1-T2) stage, early N (N0-N1) stage, and early M (M0) stage patients.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000011396</identifier><identifier>PMID: 29995783</identifier><language>eng</language><publisher>United States: The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - blood ; Blood Cell Count ; Carcinoembryonic Antigen - blood ; Female ; Gallbladder Neoplasms - blood ; Gallbladder Neoplasms - mortality ; Gallbladder Neoplasms - pathology ; Gallbladder Neoplasms - therapy ; Humans ; Inflammation - pathology ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Neoplasm Metastasis ; Neoplasm Staging ; Observational Study ; Prognosis ; Proportional Hazards Models ; Retrospective Studies</subject><ispartof>Medicine (Baltimore), 2018-07, Vol.97 (28), p.e11396-e11396</ispartof><rights>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.</rights><rights>Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4504-14d5448920533905490cb3a47d5d07ad38b3c06a2193a7b335ee8a6b364c5a9e3</citedby><cites>FETCH-LOGICAL-c4504-14d5448920533905490cb3a47d5d07ad38b3c06a2193a7b335ee8a6b364c5a9e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076111/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076111/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29995783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cui, Xiwei</creatorcontrib><creatorcontrib>Zhu, Sha</creatorcontrib><creatorcontrib>Tao, Zhihang</creatorcontrib><creatorcontrib>Deng, Xinghao</creatorcontrib><creatorcontrib>Wang, Yexiao</creatorcontrib><creatorcontrib>Gao, Yuanjing</creatorcontrib><creatorcontrib>Liao, Yue</creatorcontrib><creatorcontrib>Ma, Weijun</creatorcontrib><creatorcontrib>Zhang, Yiwen</creatorcontrib><creatorcontrib>Ma, Xuelei</creatorcontrib><title>Long-term outcomes and prognostic markers in gallbladder cancer</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Cancer-related inflammation and systemic inflammatory markers have been widely recognized as an essential part in tumor multiplication, invasion, and metastasis of tumor cells. This study aimed to estimate and compare the prognostic value of various biomarkers on overall survival (OS) in patients with gallbladder cancer patients.We performed a retrospective study of 159 patients received different therapies in West China Hospital from 2009 to 2014. The preoperative biomarker data, including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), lactate dehydrogenase, and alkaline phosphatase, as well as other clinical information, were obtained from electronic record. And the receiver operating characteristic curves were used to analyze the optimal cut-off values of them. Kaplan-Meier survival analysis and Cox proportional hazard model analysis were applied to evaluate the association between markers and OS.The optimal cut-off value was 4.39 for NLR, 181.85 for PLR, 0.30 for MLR, and 3.02 for carcinoembryonic antigen (CEA). Kaplan-Meier analysis and univariate Cox analysis both demonstrated the significant prognostic value of NLR, MLR, and CEA. However, PLR failed to be a significant predictor of OS. The multivariate Cox analysis showed that preoperative NLR and CEA were independent prognostic factors for OS.Advanced tumor/node/metastasis stage, enhanced pretherapeutic NLR, and CEA were significantly associated with worse OS of gallbladder cancer patients. Furthermore, NLR was a better prognostic factor than CEA in advanced T (T3-T4) stage patients, while CEA was better for early T (T1-T2) stage, early N (N0-N1) stage, and early M (M0) stage patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - blood</subject><subject>Blood Cell Count</subject><subject>Carcinoembryonic Antigen - blood</subject><subject>Female</subject><subject>Gallbladder Neoplasms - blood</subject><subject>Gallbladder Neoplasms - mortality</subject><subject>Gallbladder Neoplasms - pathology</subject><subject>Gallbladder Neoplasms - therapy</subject><subject>Humans</subject><subject>Inflammation - pathology</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Staging</subject><subject>Observational Study</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkE1v1DAQhi0EotuFX4CEcuSSMs74I76AUAsFaate4Gw5znQ31IkXO6Hi39ewpZT6MpLnmXdGD2OvOJxwMPrtxdkJ_Huco1FP2IpLVLU0SjxlK4BG1tpoccSOc_5eINSNeM6OGmOM1C2u2PtNnLb1TGms4jL7OFKu3NRX-xS3U8zz4KvRpWtKuRqmautC6ILre0qVd5On9II9u3Ih08u7umbfPn38evq53lyefzn9sKm9kCBqLnopRGsakIgGpDDgO3RC97IH7XpsO_SgXMMNOt0hSqLWqQ6V8NIZwjV7d8jdL91IvadpTi7YfRrKeb9sdIP9vzMNO7uNP60CrXiRs2Zv7gJS_LFQnu04ZE8huInikm0DqjUFBFVQPKA-xZwTXd2v4WB_q7cXZ_ax-jL1-uGF9zN_XRdAHICbGIrwfB2WG0p2Ry7Muz95UpumboC3oDlCXX5Q4C2lBI4o</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Cui, Xiwei</creator><creator>Zhu, Sha</creator><creator>Tao, Zhihang</creator><creator>Deng, Xinghao</creator><creator>Wang, Yexiao</creator><creator>Gao, Yuanjing</creator><creator>Liao, Yue</creator><creator>Ma, Weijun</creator><creator>Zhang, Yiwen</creator><creator>Ma, Xuelei</creator><general>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</general><general>Wolters Kluwer Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180701</creationdate><title>Long-term outcomes and prognostic markers in gallbladder cancer</title><author>Cui, Xiwei ; Zhu, Sha ; Tao, Zhihang ; Deng, Xinghao ; Wang, Yexiao ; Gao, Yuanjing ; Liao, Yue ; Ma, Weijun ; Zhang, Yiwen ; Ma, Xuelei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4504-14d5448920533905490cb3a47d5d07ad38b3c06a2193a7b335ee8a6b364c5a9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - blood</topic><topic>Blood Cell Count</topic><topic>Carcinoembryonic Antigen - blood</topic><topic>Female</topic><topic>Gallbladder Neoplasms - blood</topic><topic>Gallbladder Neoplasms - mortality</topic><topic>Gallbladder Neoplasms - pathology</topic><topic>Gallbladder Neoplasms - therapy</topic><topic>Humans</topic><topic>Inflammation - pathology</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Staging</topic><topic>Observational Study</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cui, Xiwei</creatorcontrib><creatorcontrib>Zhu, Sha</creatorcontrib><creatorcontrib>Tao, Zhihang</creatorcontrib><creatorcontrib>Deng, Xinghao</creatorcontrib><creatorcontrib>Wang, Yexiao</creatorcontrib><creatorcontrib>Gao, Yuanjing</creatorcontrib><creatorcontrib>Liao, Yue</creatorcontrib><creatorcontrib>Ma, Weijun</creatorcontrib><creatorcontrib>Zhang, Yiwen</creatorcontrib><creatorcontrib>Ma, Xuelei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cui, Xiwei</au><au>Zhu, Sha</au><au>Tao, Zhihang</au><au>Deng, Xinghao</au><au>Wang, Yexiao</au><au>Gao, Yuanjing</au><au>Liao, Yue</au><au>Ma, Weijun</au><au>Zhang, Yiwen</au><au>Ma, Xuelei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term outcomes and prognostic markers in gallbladder cancer</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>97</volume><issue>28</issue><spage>e11396</spage><epage>e11396</epage><pages>e11396-e11396</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Cancer-related inflammation and systemic inflammatory markers have been widely recognized as an essential part in tumor multiplication, invasion, and metastasis of tumor cells. This study aimed to estimate and compare the prognostic value of various biomarkers on overall survival (OS) in patients with gallbladder cancer patients.We performed a retrospective study of 159 patients received different therapies in West China Hospital from 2009 to 2014. The preoperative biomarker data, including neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), lactate dehydrogenase, and alkaline phosphatase, as well as other clinical information, were obtained from electronic record. And the receiver operating characteristic curves were used to analyze the optimal cut-off values of them. Kaplan-Meier survival analysis and Cox proportional hazard model analysis were applied to evaluate the association between markers and OS.The optimal cut-off value was 4.39 for NLR, 181.85 for PLR, 0.30 for MLR, and 3.02 for carcinoembryonic antigen (CEA). Kaplan-Meier analysis and univariate Cox analysis both demonstrated the significant prognostic value of NLR, MLR, and CEA. However, PLR failed to be a significant predictor of OS. The multivariate Cox analysis showed that preoperative NLR and CEA were independent prognostic factors for OS.Advanced tumor/node/metastasis stage, enhanced pretherapeutic NLR, and CEA were significantly associated with worse OS of gallbladder cancer patients. Furthermore, NLR was a better prognostic factor than CEA in advanced T (T3-T4) stage patients, while CEA was better for early T (T1-T2) stage, early N (N0-N1) stage, and early M (M0) stage patients.</abstract><cop>United States</cop><pub>The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>29995783</pmid><doi>10.1097/MD.0000000000011396</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0025-7974 |
| ispartof | Medicine (Baltimore), 2018-07, Vol.97 (28), p.e11396-e11396 |
| issn | 0025-7974 1536-5964 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6076111 |
| source | IngentaConnect; MEDLINE; PubMed Central; Directory of Open Access Journals; Alma/SFX Local Collection; EZB Electronic Journals Library; Wolters Kluwer Open Access |
| subjects | Adult Aged Aged, 80 and over Biomarkers, Tumor - blood Blood Cell Count Carcinoembryonic Antigen - blood Female Gallbladder Neoplasms - blood Gallbladder Neoplasms - mortality Gallbladder Neoplasms - pathology Gallbladder Neoplasms - therapy Humans Inflammation - pathology Kaplan-Meier Estimate Male Middle Aged Neoplasm Metastasis Neoplasm Staging Observational Study Prognosis Proportional Hazards Models Retrospective Studies |
| title | Long-term outcomes and prognostic markers in gallbladder cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T16%3A05%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Long-term%20outcomes%20and%20prognostic%20markers%20in%20gallbladder%20cancer&rft.jtitle=Medicine%20(Baltimore)&rft.au=Cui,%20Xiwei&rft.date=2018-07-01&rft.volume=97&rft.issue=28&rft.spage=e11396&rft.epage=e11396&rft.pages=e11396-e11396&rft.issn=0025-7974&rft.eissn=1536-5964&rft_id=info:doi/10.1097/MD.0000000000011396&rft_dat=%3Cproquest_pubme%3E2068911106%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2068911106&rft_id=info:pmid/29995783&rfr_iscdi=true |