Chordoma Occurs in Young Children With Tuberous Sclerosis

Chordomas are rare bony neoplasms usually unassociated with a familial tumor predisposition syndrome. The peak incidence of this midline axial skeletal tumor is in adulthood but when very young children are affected, consideration should be given to occurrence within the tuberous sclerosis (TS) comp...

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Veröffentlicht in:	Journal of neuropathology and experimental neurology 2017-06, Vol.76 (6), p.418-423
Hauptverfasser:	Dahl, Nathan A, Luebbert, Timothy, Loi, Michele, Neuberger, Ilana, Handler, Michael H, Kleinschmidt-DeMasters, Bette Kay, Mulcahy Levy, Jean M
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiomyolipoma - diagnostic imaging Angiomyolipoma - pathology Chordoma - diagnostic imaging Chordoma - genetics Chordoma - pathology Heart Neoplasms - diagnostic imaging Heart Neoplasms - secondary Humans Infant Kidney Neoplasms - diagnostic imaging Kidney Neoplasms - secondary Lung Neoplasms - diagnostic imaging Lung Neoplasms - secondary Magnetic Resonance Imaging Male Neoplasm Metastasis Review Rhabdomyoma - pathology Skin Neoplasms - diagnostic imaging Skin Neoplasms - pathology Skin Neoplasms - secondary Skull Base Neoplasms - diagnostic imaging Skull Base Neoplasms - genetics Skull Base Neoplasms - pathology Tuberous Sclerosis - diagnostic imaging Tuberous Sclerosis - pathology Tumor Suppressor Proteins - genetics
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Beschreibung
Zusammenfassung:	Chordomas are rare bony neoplasms usually unassociated with a familial tumor predisposition syndrome. The peak incidence of this midline axial skeletal tumor is in adulthood but when very young children are affected, consideration should be given to occurrence within the tuberous sclerosis (TS) complex, especially when presenting in neonates
ISSN:	0022-3069 1554-6578
DOI:	10.1093/jnen/nlx032