Astragalus Polysaccharide Protects Neurons and Stabilizes Mitochondrial in a Mouse Model of Parkinson Disease
BACKGROUND Astragalus polysaccharides (APS) have a very good therapeutic effect in the treatment of neurodegenerative diseases and nerve injury disease. However, research on Parkinson disease (PD) treatment with APS is lacking. MATERIAL AND METHODS The present study was designed to explore the effec...
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| Veröffentlicht in: | Medical science monitor 2018-07, Vol.24, p.5192-5199 |
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| creator | Liu, Hong Chen, Si Guo, Cunju Tang, Wenqiang Liu, Wei Liu, Yiming |
| description | BACKGROUND Astragalus polysaccharides (APS) have a very good therapeutic effect in the treatment of neurodegenerative diseases and nerve injury disease. However, research on Parkinson disease (PD) treatment with APS is lacking. MATERIAL AND METHODS The present study was designed to explore the effects of APS on the protection of neurons and mitochondrial in a mouse model of PD using behavioral experiments, and observations of mitochondrial structure and transmembrane potential. RESULTS It was shown that APS could attenuate 1-methyl-4-pheyl-1,2,3,6-tetrahydropyridine (MPTP)-induced motor dysfunction (P |
| doi_str_mv | 10.12659/MSM.908021 |
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However, research on Parkinson disease (PD) treatment with APS is lacking. MATERIAL AND METHODS The present study was designed to explore the effects of APS on the protection of neurons and mitochondrial in a mouse model of PD using behavioral experiments, and observations of mitochondrial structure and transmembrane potential. RESULTS It was shown that APS could attenuate 1-methyl-4-pheyl-1,2,3,6-tetrahydropyridine (MPTP)-induced motor dysfunction (P<0.01), increase the proportion of TH-positive cells (P<0.01), reverse MPTP-induced mitochondrial structural damage, and reduce MPTP-induced high levels of reactive oxygen species (ROS) and increase MPTP-induced decrease in mitochondrial membrane potential. In addition, APS also decreased the bax/bcl2 ratio, and cytochrome-c and caspase-3 protein content (P<0.01) in substantia nigra in our mouse PD model. CONCLUSIONS APS provided a protective effect on neurons and mitochondrial in a mouse PD model.</description><identifier>ISSN: 1643-3750</identifier><identifier>ISSN: 1234-1010</identifier><identifier>EISSN: 1643-3750</identifier><identifier>DOI: 10.12659/MSM.908021</identifier><identifier>PMID: 30048421</identifier><language>eng</language><publisher>United States: International Scientific Literature, Inc</publisher><subject>Animal Study ; Animals ; Apoptosis - drug effects ; Astragalus Plant - metabolism ; China ; Disease Models, Animal ; Male ; Membrane Potential, Mitochondrial - drug effects ; Mice ; Mice, Inbred C57BL ; Mitochondria - drug effects ; Mitochondria - metabolism ; Neurons - metabolism ; Neuroprotective Agents - pharmacology ; Oxidative Stress - drug effects ; Parkinson Disease - drug therapy ; Plant Extracts - pharmacology ; Polysaccharides - pharmacology ; Reactive Oxygen Species - metabolism ; Substantia Nigra - metabolism</subject><ispartof>Medical science monitor, 2018-07, Vol.24, p.5192-5199</ispartof><rights>Med Sci Monit, 2018 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-a6eb1c3ea129b723f8d254064d1d5ca8d2162fa48e397c279408f5fa82ec7e593</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074062/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6074062/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30048421$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Hong</creatorcontrib><creatorcontrib>Chen, Si</creatorcontrib><creatorcontrib>Guo, Cunju</creatorcontrib><creatorcontrib>Tang, Wenqiang</creatorcontrib><creatorcontrib>Liu, Wei</creatorcontrib><creatorcontrib>Liu, Yiming</creatorcontrib><title>Astragalus Polysaccharide Protects Neurons and Stabilizes Mitochondrial in a Mouse Model of Parkinson Disease</title><title>Medical science monitor</title><addtitle>Med Sci Monit</addtitle><description>BACKGROUND Astragalus polysaccharides (APS) have a very good therapeutic effect in the treatment of neurodegenerative diseases and nerve injury disease. However, research on Parkinson disease (PD) treatment with APS is lacking. MATERIAL AND METHODS The present study was designed to explore the effects of APS on the protection of neurons and mitochondrial in a mouse model of PD using behavioral experiments, and observations of mitochondrial structure and transmembrane potential. RESULTS It was shown that APS could attenuate 1-methyl-4-pheyl-1,2,3,6-tetrahydropyridine (MPTP)-induced motor dysfunction (P<0.01), increase the proportion of TH-positive cells (P<0.01), reverse MPTP-induced mitochondrial structural damage, and reduce MPTP-induced high levels of reactive oxygen species (ROS) and increase MPTP-induced decrease in mitochondrial membrane potential. In addition, APS also decreased the bax/bcl2 ratio, and cytochrome-c and caspase-3 protein content (P<0.01) in substantia nigra in our mouse PD model. CONCLUSIONS APS provided a protective effect on neurons and mitochondrial in a mouse PD model.</description><subject>Animal Study</subject><subject>Animals</subject><subject>Apoptosis - drug effects</subject><subject>Astragalus Plant - metabolism</subject><subject>China</subject><subject>Disease Models, Animal</subject><subject>Male</subject><subject>Membrane Potential, Mitochondrial - drug effects</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mitochondria - drug effects</subject><subject>Mitochondria - metabolism</subject><subject>Neurons - metabolism</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Oxidative Stress - drug effects</subject><subject>Parkinson Disease - drug therapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Polysaccharides - pharmacology</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Substantia Nigra - metabolism</subject><issn>1643-3750</issn><issn>1234-1010</issn><issn>1643-3750</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUV1LHDEUDWKpVvvke8mjUNbmYzKTeRHEfoJbF2yfw93MHTc1m9jcmYL99Q1dK_blfnAP59zDYexEijOpWtO_W94sz3phhZJ77FC2jV7ozoj9Z_MBe0X0QwhlW2FesgMtRGMbJQ_Z9oKmArcQZ-KrHB8IvN9ACQPyVckT-on4V5xLTsQhDfxmgnWI4TcSX4Yp-01OQwkQeUgc-DLPhLUOGHke-QrKXUiUE38fCIHwmL0YIRK-fuxH7PvHD98uPy-urj99uby4Wnht5bSAFtfSawSp-nWn9GgHZRrRNoMcjIe6yVaN0FjUfedV1zfCjmYEq9B3aHp9xM53vPfzeouDx1RNRndfwhbKg8sQ3P-XFDbuNv9yreiqjqoEp48EJf-ckSa3DeQxRkhYPTolOmusEbqt0Lc7qC-ZqOD4JCOF-xuQqwG5XUAV_eb5Z0_Yf4noP_ArjcM</recordid><startdate>20180726</startdate><enddate>20180726</enddate><creator>Liu, Hong</creator><creator>Chen, Si</creator><creator>Guo, Cunju</creator><creator>Tang, Wenqiang</creator><creator>Liu, Wei</creator><creator>Liu, Yiming</creator><general>International Scientific Literature, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180726</creationdate><title>Astragalus Polysaccharide Protects Neurons and Stabilizes Mitochondrial in a Mouse Model of Parkinson Disease</title><author>Liu, Hong ; Chen, Si ; Guo, Cunju ; Tang, Wenqiang ; Liu, Wei ; Liu, Yiming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-a6eb1c3ea129b723f8d254064d1d5ca8d2162fa48e397c279408f5fa82ec7e593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animal Study</topic><topic>Animals</topic><topic>Apoptosis - drug effects</topic><topic>Astragalus Plant - metabolism</topic><topic>China</topic><topic>Disease Models, Animal</topic><topic>Male</topic><topic>Membrane Potential, Mitochondrial - drug effects</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mitochondria - drug effects</topic><topic>Mitochondria - metabolism</topic><topic>Neurons - metabolism</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Oxidative Stress - drug effects</topic><topic>Parkinson Disease - drug therapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Polysaccharides - pharmacology</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Substantia Nigra - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Liu, Hong</creatorcontrib><creatorcontrib>Chen, Si</creatorcontrib><creatorcontrib>Guo, Cunju</creatorcontrib><creatorcontrib>Tang, Wenqiang</creatorcontrib><creatorcontrib>Liu, Wei</creatorcontrib><creatorcontrib>Liu, Yiming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medical science monitor</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Hong</au><au>Chen, Si</au><au>Guo, Cunju</au><au>Tang, Wenqiang</au><au>Liu, Wei</au><au>Liu, Yiming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Astragalus Polysaccharide Protects Neurons and Stabilizes Mitochondrial in a Mouse Model of Parkinson Disease</atitle><jtitle>Medical science monitor</jtitle><addtitle>Med Sci Monit</addtitle><date>2018-07-26</date><risdate>2018</risdate><volume>24</volume><spage>5192</spage><epage>5199</epage><pages>5192-5199</pages><issn>1643-3750</issn><issn>1234-1010</issn><eissn>1643-3750</eissn><abstract>BACKGROUND Astragalus polysaccharides (APS) have a very good therapeutic effect in the treatment of neurodegenerative diseases and nerve injury disease. However, research on Parkinson disease (PD) treatment with APS is lacking. MATERIAL AND METHODS The present study was designed to explore the effects of APS on the protection of neurons and mitochondrial in a mouse model of PD using behavioral experiments, and observations of mitochondrial structure and transmembrane potential. RESULTS It was shown that APS could attenuate 1-methyl-4-pheyl-1,2,3,6-tetrahydropyridine (MPTP)-induced motor dysfunction (P<0.01), increase the proportion of TH-positive cells (P<0.01), reverse MPTP-induced mitochondrial structural damage, and reduce MPTP-induced high levels of reactive oxygen species (ROS) and increase MPTP-induced decrease in mitochondrial membrane potential. In addition, APS also decreased the bax/bcl2 ratio, and cytochrome-c and caspase-3 protein content (P<0.01) in substantia nigra in our mouse PD model. CONCLUSIONS APS provided a protective effect on neurons and mitochondrial in a mouse PD model.</abstract><cop>United States</cop><pub>International Scientific Literature, Inc</pub><pmid>30048421</pmid><doi>10.12659/MSM.908021</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animal Study Animals Apoptosis - drug effects Astragalus Plant - metabolism China Disease Models, Animal Male Membrane Potential, Mitochondrial - drug effects Mice Mice, Inbred C57BL Mitochondria - drug effects Mitochondria - metabolism Neurons - metabolism Neuroprotective Agents - pharmacology Oxidative Stress - drug effects Parkinson Disease - drug therapy Plant Extracts - pharmacology Polysaccharides - pharmacology Reactive Oxygen Species - metabolism Substantia Nigra - metabolism |
| title | Astragalus Polysaccharide Protects Neurons and Stabilizes Mitochondrial in a Mouse Model of Parkinson Disease |
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