Astragalus Polysaccharide Protects Neurons and Stabilizes Mitochondrial in a Mouse Model of Parkinson Disease

BACKGROUND Astragalus polysaccharides (APS) have a very good therapeutic effect in the treatment of neurodegenerative diseases and nerve injury disease. However, research on Parkinson disease (PD) treatment with APS is lacking. MATERIAL AND METHODS The present study was designed to explore the effec...

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Veröffentlicht in:	Medical science monitor 2018-07, Vol.24, p.5192-5199
Hauptverfasser:	Liu, Hong, Chen, Si, Guo, Cunju, Tang, Wenqiang, Liu, Wei, Liu, Yiming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Study Animals Apoptosis - drug effects Astragalus Plant - metabolism China Disease Models, Animal Male Membrane Potential, Mitochondrial - drug effects Mice Mice, Inbred C57BL Mitochondria - drug effects Mitochondria - metabolism Neurons - metabolism Neuroprotective Agents - pharmacology Oxidative Stress - drug effects Parkinson Disease - drug therapy Plant Extracts - pharmacology Polysaccharides - pharmacology Reactive Oxygen Species - metabolism Substantia Nigra - metabolism
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Zusammenfassung:	BACKGROUND Astragalus polysaccharides (APS) have a very good therapeutic effect in the treatment of neurodegenerative diseases and nerve injury disease. However, research on Parkinson disease (PD) treatment with APS is lacking. MATERIAL AND METHODS The present study was designed to explore the effects of APS on the protection of neurons and mitochondrial in a mouse model of PD using behavioral experiments, and observations of mitochondrial structure and transmembrane potential. RESULTS It was shown that APS could attenuate 1-methyl-4-pheyl-1,2,3,6-tetrahydropyridine (MPTP)-induced motor dysfunction (P
ISSN:	1643-3750 1234-1010 1643-3750
DOI:	10.12659/MSM.908021