Development of selective agents targeting serotonin 5HT1A receptors with subnanomolar activities based on a coumarin core

A series of 18 new 5-[3-(4-aryl-1-piperazinyl)propoxy]coumarin derivatives from the corresponding bromoalkyl derivatives have been designed and synthesized by us using a microwave-assisted protocol. Radioligand binding assays of this series of compounds as well as a previously synthesized series of...

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Veröffentlicht in:	MedChemComm 2017-08, Vol.8 (8), p.1690-1696
Hauptverfasser:	Ostrowska, K, Grzeszczuk, D, Głuch-Lutwin, M, Gryboś, A, Siwek, A, Dobrzycki, Ł, Trzaskowski, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry
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