Synthesis and preliminary anti-inflammatory and anti-bacterial evaluation of some diflunisal aza-analogs

Our aim was to identify new multi-target compounds endowed with both anti-inflammatory and anti-bacterial activities for treatment of human infections. Diflunisal, a nonsteroidal anti-inflammatory agent, has recently been repurposed for its anti-virulence properties against methicillin-resistant . E...

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Veröffentlicht in:	MedChemComm 2018-06, Vol.9 (6), p.1017-1032
Hauptverfasser:	Carta, Davide, Brun, Paola, Dal Pra, Matteo, Bernabè, Giulia, Castagliuolo, Ignazio, Ferlin, Maria Grazia
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides Analogs Antibacterial activity Antibiotics Bacteria Chemistry Cytokines Cytotoxicity Drug resistance Inflammation Intermediates Lipopolysaccharides Macrophages Methicillin Oxazole Penicillin Prostaglandins Protein biosynthesis Protein synthesis Proteins Pseudomonas aeruginosa Sensitizing Staphylococcus infections Streptococcus infections Target recognition Virulence β-Lactam antibiotics
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