Air Pollution and Glucose Metabolism: An Analysis in Non-Diabetic Participants of the Heinz Nixdorf Recall Study
Despite the importance of understanding the connection between air pollution exposure and diabetes, studies investigating links between air pollution and glucose metabolism in nondiabetic adults are limited. We aimed to estimate the association of medium-term air pollution exposures with blood gluco...
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| Veröffentlicht in: | Environmental health perspectives 2018-04, Vol.126 (4), p.047001-047001 |
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| creator | Lucht, Sarah A Hennig, Frauke Matthiessen, Clara Ohlwein, Simone Icks, Andrea Moebus, Susanne Jöckel, Karl-Heinz Jakobs, Hermann Hoffmann, Barbara |
| description | Despite the importance of understanding the connection between air pollution exposure and diabetes, studies investigating links between air pollution and glucose metabolism in nondiabetic adults are limited.
We aimed to estimate the association of medium-term air pollution exposures with blood glucose and glycated hemoglobin A1c (HbA1c) among nondiabetics.
This study included observations from nondiabetic participants (n
=7,108) of the population-based Heinz Nixdorf Recall study at baseline (2000–2003) and follow-up examination (2006–2008). Daily fine particulate matter (aerodynamic diameter≤2.5 μm, PM
; aerodynamic diameter≤10 μm, PM
), accumulation mode particle number (PN
), and nitrogen dioxide (NO
) exposures were estimated at participants’ residences using the spatiotemporal European Air Pollution Dispersion (EURAD) chemistry transport model. We evaluated the associations between medium-term air pollution exposures (28- and 91-d means) and glucose metabolism measures using mixed linear regression and adjusting for season, meteorology, and personal characteristics. A range of other exposure windows (1-, 2-, 3-, 7-, 14-, 45-, 60-, 75-, 105-, 120-, and 182-d means) were also evaluated to identify potentially relevant biological windows.
We observed positive associations between PM
and PN
exposures and blood glucose levels [e.g., 28-d PM
: 0.91 mg/dL (95% CI: 0.38, 1.44) per 5.7 μg/m
]. PM
, PM
, and PN
exposures were positively associated with HbA1c [e.g., 91-d PM
: 0.07 p.p. (95% CI: 0.04, 0.10) per 4.0 μg/m
]. Mean exposures during longer exposure windows (75- to 105-d) were most strongly associated with HbA1c, whereas 7- to 45-d exposures were most strongly associated with blood glucose. NO
exposure was not associated with blood glucose or with HbA1c.
Medium-term PM and PN
exposures were positively associated with glucose measures in nondiabetic adults. These findings indicate that reducing ambient air pollution levels may decrease the risk of diabetes. https://doi.org/10.1289/EHP2561. |
| doi_str_mv | 10.1289/EHP2561 |
| format | Article |
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We aimed to estimate the association of medium-term air pollution exposures with blood glucose and glycated hemoglobin A1c (HbA1c) among nondiabetics.
This study included observations from nondiabetic participants (n
=7,108) of the population-based Heinz Nixdorf Recall study at baseline (2000–2003) and follow-up examination (2006–2008). Daily fine particulate matter (aerodynamic diameter≤2.5 μm, PM
; aerodynamic diameter≤10 μm, PM
), accumulation mode particle number (PN
), and nitrogen dioxide (NO
) exposures were estimated at participants’ residences using the spatiotemporal European Air Pollution Dispersion (EURAD) chemistry transport model. We evaluated the associations between medium-term air pollution exposures (28- and 91-d means) and glucose metabolism measures using mixed linear regression and adjusting for season, meteorology, and personal characteristics. A range of other exposure windows (1-, 2-, 3-, 7-, 14-, 45-, 60-, 75-, 105-, 120-, and 182-d means) were also evaluated to identify potentially relevant biological windows.
We observed positive associations between PM
and PN
exposures and blood glucose levels [e.g., 28-d PM
: 0.91 mg/dL (95% CI: 0.38, 1.44) per 5.7 μg/m
]. PM
, PM
, and PN
exposures were positively associated with HbA1c [e.g., 91-d PM
: 0.07 p.p. (95% CI: 0.04, 0.10) per 4.0 μg/m
]. Mean exposures during longer exposure windows (75- to 105-d) were most strongly associated with HbA1c, whereas 7- to 45-d exposures were most strongly associated with blood glucose. NO
exposure was not associated with blood glucose or with HbA1c.
Medium-term PM and PN
exposures were positively associated with glucose measures in nondiabetic adults. These findings indicate that reducing ambient air pollution levels may decrease the risk of diabetes. https://doi.org/10.1289/EHP2561.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/EHP2561</identifier><identifier>PMID: 29616776</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences</publisher><subject>Adults ; Aged ; Air Pollutants - adverse effects ; Air pollution ; Air Pollution - adverse effects ; Air pollution measurements ; Analysis ; Biological effects ; Blood ; Blood glucose ; Blood Glucose - analysis ; Blood levels ; Care and treatment ; Causes of ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - etiology ; Environmental Exposure - adverse effects ; Environmental risk ; Epidemiology ; Estimates ; Exposure ; Female ; Food and nutrition ; Glucose ; Glucose metabolism ; Glycated Hemoglobin A - metabolism ; Glycosylated hemoglobin ; Health aspects ; Health risks ; Hemoglobin ; Humans ; Inflammation ; Insulin resistance ; Lung cancer ; Male ; Metabolism ; Meteorology ; Middle Aged ; Mortality ; Nitrogen dioxide ; Nitrogen Dioxide - adverse effects ; Noise ; Outdoor air quality ; Particulate emissions ; Particulate matter ; Particulate Matter - adverse effects ; Pollution ; Pollution control ; Pollution dispersion ; Pollution levels ; Recall ; Reference Values ; Regression analysis ; Risk factors ; Risk reduction ; Studies ; Sulfur ; Systematic review ; VOCs ; Volatile organic compounds</subject><ispartof>Environmental health perspectives, 2018-04, Vol.126 (4), p.047001-047001</ispartof><rights>COPYRIGHT 2018 National Institute of Environmental Health Sciences</rights><rights>Copyright National Institute of Environmental Health Sciences Apr 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c601t-f8054699be966443caf3b97a888d6b2badae51b179aca259b9331f7875d0cb543</citedby><cites>FETCH-LOGICAL-c601t-f8054699be966443caf3b97a888d6b2badae51b179aca259b9331f7875d0cb543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071794/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071794/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29616776$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lucht, Sarah A</creatorcontrib><creatorcontrib>Hennig, Frauke</creatorcontrib><creatorcontrib>Matthiessen, Clara</creatorcontrib><creatorcontrib>Ohlwein, Simone</creatorcontrib><creatorcontrib>Icks, Andrea</creatorcontrib><creatorcontrib>Moebus, Susanne</creatorcontrib><creatorcontrib>Jöckel, Karl-Heinz</creatorcontrib><creatorcontrib>Jakobs, Hermann</creatorcontrib><creatorcontrib>Hoffmann, Barbara</creatorcontrib><title>Air Pollution and Glucose Metabolism: An Analysis in Non-Diabetic Participants of the Heinz Nixdorf Recall Study</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>Despite the importance of understanding the connection between air pollution exposure and diabetes, studies investigating links between air pollution and glucose metabolism in nondiabetic adults are limited.
We aimed to estimate the association of medium-term air pollution exposures with blood glucose and glycated hemoglobin A1c (HbA1c) among nondiabetics.
This study included observations from nondiabetic participants (n
=7,108) of the population-based Heinz Nixdorf Recall study at baseline (2000–2003) and follow-up examination (2006–2008). Daily fine particulate matter (aerodynamic diameter≤2.5 μm, PM
; aerodynamic diameter≤10 μm, PM
), accumulation mode particle number (PN
), and nitrogen dioxide (NO
) exposures were estimated at participants’ residences using the spatiotemporal European Air Pollution Dispersion (EURAD) chemistry transport model. We evaluated the associations between medium-term air pollution exposures (28- and 91-d means) and glucose metabolism measures using mixed linear regression and adjusting for season, meteorology, and personal characteristics. A range of other exposure windows (1-, 2-, 3-, 7-, 14-, 45-, 60-, 75-, 105-, 120-, and 182-d means) were also evaluated to identify potentially relevant biological windows.
We observed positive associations between PM
and PN
exposures and blood glucose levels [e.g., 28-d PM
: 0.91 mg/dL (95% CI: 0.38, 1.44) per 5.7 μg/m
]. PM
, PM
, and PN
exposures were positively associated with HbA1c [e.g., 91-d PM
: 0.07 p.p. (95% CI: 0.04, 0.10) per 4.0 μg/m
]. Mean exposures during longer exposure windows (75- to 105-d) were most strongly associated with HbA1c, whereas 7- to 45-d exposures were most strongly associated with blood glucose. NO
exposure was not associated with blood glucose or with HbA1c.
Medium-term PM and PN
exposures were positively associated with glucose measures in nondiabetic adults. These findings indicate that reducing ambient air pollution levels may decrease the risk of diabetes. https://doi.org/10.1289/EHP2561.</description><subject>Adults</subject><subject>Aged</subject><subject>Air Pollutants - adverse effects</subject><subject>Air pollution</subject><subject>Air Pollution - adverse effects</subject><subject>Air pollution measurements</subject><subject>Analysis</subject><subject>Biological effects</subject><subject>Blood</subject><subject>Blood glucose</subject><subject>Blood Glucose - analysis</subject><subject>Blood levels</subject><subject>Care and treatment</subject><subject>Causes of</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - etiology</subject><subject>Environmental Exposure - adverse effects</subject><subject>Environmental risk</subject><subject>Epidemiology</subject><subject>Estimates</subject><subject>Exposure</subject><subject>Female</subject><subject>Food and nutrition</subject><subject>Glucose</subject><subject>Glucose metabolism</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Glycosylated hemoglobin</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Insulin resistance</subject><subject>Lung cancer</subject><subject>Male</subject><subject>Metabolism</subject><subject>Meteorology</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Nitrogen dioxide</subject><subject>Nitrogen Dioxide - adverse effects</subject><subject>Noise</subject><subject>Outdoor air quality</subject><subject>Particulate emissions</subject><subject>Particulate matter</subject><subject>Particulate Matter - adverse effects</subject><subject>Pollution</subject><subject>Pollution control</subject><subject>Pollution dispersion</subject><subject>Pollution levels</subject><subject>Recall</subject><subject>Reference Values</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Risk reduction</subject><subject>Studies</subject><subject>Sulfur</subject><subject>Systematic review</subject><subject>VOCs</subject><subject>Volatile organic 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Pollution and Glucose Metabolism: An Analysis in Non-Diabetic Participants of the Heinz Nixdorf Recall Study</title><author>Lucht, Sarah A ; Hennig, Frauke ; Matthiessen, Clara ; Ohlwein, Simone ; Icks, Andrea ; Moebus, Susanne ; Jöckel, Karl-Heinz ; Jakobs, Hermann ; Hoffmann, Barbara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c601t-f8054699be966443caf3b97a888d6b2badae51b179aca259b9331f7875d0cb543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adults</topic><topic>Aged</topic><topic>Air Pollutants - adverse effects</topic><topic>Air pollution</topic><topic>Air Pollution - adverse effects</topic><topic>Air pollution measurements</topic><topic>Analysis</topic><topic>Biological effects</topic><topic>Blood</topic><topic>Blood glucose</topic><topic>Blood Glucose - analysis</topic><topic>Blood levels</topic><topic>Care and treatment</topic><topic>Causes of</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus - etiology</topic><topic>Environmental Exposure - adverse effects</topic><topic>Environmental risk</topic><topic>Epidemiology</topic><topic>Estimates</topic><topic>Exposure</topic><topic>Female</topic><topic>Food and nutrition</topic><topic>Glucose</topic><topic>Glucose metabolism</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Glycosylated hemoglobin</topic><topic>Health aspects</topic><topic>Health risks</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Insulin resistance</topic><topic>Lung cancer</topic><topic>Male</topic><topic>Metabolism</topic><topic>Meteorology</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Nitrogen dioxide</topic><topic>Nitrogen Dioxide - adverse effects</topic><topic>Noise</topic><topic>Outdoor air quality</topic><topic>Particulate emissions</topic><topic>Particulate matter</topic><topic>Particulate Matter - adverse effects</topic><topic>Pollution</topic><topic>Pollution control</topic><topic>Pollution dispersion</topic><topic>Pollution levels</topic><topic>Recall</topic><topic>Reference Values</topic><topic>Regression analysis</topic><topic>Risk factors</topic><topic>Risk reduction</topic><topic>Studies</topic><topic>Sulfur</topic><topic>Systematic review</topic><topic>VOCs</topic><topic>Volatile organic compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lucht, Sarah A</creatorcontrib><creatorcontrib>Hennig, Frauke</creatorcontrib><creatorcontrib>Matthiessen, Clara</creatorcontrib><creatorcontrib>Ohlwein, Simone</creatorcontrib><creatorcontrib>Icks, Andrea</creatorcontrib><creatorcontrib>Moebus, Susanne</creatorcontrib><creatorcontrib>Jöckel, Karl-Heinz</creatorcontrib><creatorcontrib>Jakobs, Hermann</creatorcontrib><creatorcontrib>Hoffmann, 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Business</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Environmental health perspectives</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lucht, Sarah A</au><au>Hennig, Frauke</au><au>Matthiessen, Clara</au><au>Ohlwein, Simone</au><au>Icks, Andrea</au><au>Moebus, Susanne</au><au>Jöckel, Karl-Heinz</au><au>Jakobs, Hermann</au><au>Hoffmann, Barbara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Air Pollution and Glucose Metabolism: An Analysis in Non-Diabetic Participants of the Heinz Nixdorf Recall Study</atitle><jtitle>Environmental health perspectives</jtitle><addtitle>Environ Health Perspect</addtitle><date>2018-04-01</date><risdate>2018</risdate><volume>126</volume><issue>4</issue><spage>047001</spage><epage>047001</epage><pages>047001-047001</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>Despite the importance of understanding the connection between air pollution exposure and diabetes, studies investigating links between air pollution and glucose metabolism in nondiabetic adults are limited.
We aimed to estimate the association of medium-term air pollution exposures with blood glucose and glycated hemoglobin A1c (HbA1c) among nondiabetics.
This study included observations from nondiabetic participants (n
=7,108) of the population-based Heinz Nixdorf Recall study at baseline (2000–2003) and follow-up examination (2006–2008). Daily fine particulate matter (aerodynamic diameter≤2.5 μm, PM
; aerodynamic diameter≤10 μm, PM
), accumulation mode particle number (PN
), and nitrogen dioxide (NO
) exposures were estimated at participants’ residences using the spatiotemporal European Air Pollution Dispersion (EURAD) chemistry transport model. We evaluated the associations between medium-term air pollution exposures (28- and 91-d means) and glucose metabolism measures using mixed linear regression and adjusting for season, meteorology, and personal characteristics. A range of other exposure windows (1-, 2-, 3-, 7-, 14-, 45-, 60-, 75-, 105-, 120-, and 182-d means) were also evaluated to identify potentially relevant biological windows.
We observed positive associations between PM
and PN
exposures and blood glucose levels [e.g., 28-d PM
: 0.91 mg/dL (95% CI: 0.38, 1.44) per 5.7 μg/m
]. PM
, PM
, and PN
exposures were positively associated with HbA1c [e.g., 91-d PM
: 0.07 p.p. (95% CI: 0.04, 0.10) per 4.0 μg/m
]. Mean exposures during longer exposure windows (75- to 105-d) were most strongly associated with HbA1c, whereas 7- to 45-d exposures were most strongly associated with blood glucose. NO
exposure was not associated with blood glucose or with HbA1c.
Medium-term PM and PN
exposures were positively associated with glucose measures in nondiabetic adults. These findings indicate that reducing ambient air pollution levels may decrease the risk of diabetes. https://doi.org/10.1289/EHP2561.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences</pub><pmid>29616776</pmid><doi>10.1289/EHP2561</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-6765 |
| ispartof | Environmental health perspectives, 2018-04, Vol.126 (4), p.047001-047001 |
| issn | 0091-6765 1552-9924 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6071794 |
| source | Jstor Complete Legacy; MEDLINE; PMC (PubMed Central); DOAJ Directory of Open Access Journals; EZB*; PubMed Central Open Access |
| subjects | Adults Aged Air Pollutants - adverse effects Air pollution Air Pollution - adverse effects Air pollution measurements Analysis Biological effects Blood Blood glucose Blood Glucose - analysis Blood levels Care and treatment Causes of Diabetes Diabetes mellitus Diabetes Mellitus - etiology Environmental Exposure - adverse effects Environmental risk Epidemiology Estimates Exposure Female Food and nutrition Glucose Glucose metabolism Glycated Hemoglobin A - metabolism Glycosylated hemoglobin Health aspects Health risks Hemoglobin Humans Inflammation Insulin resistance Lung cancer Male Metabolism Meteorology Middle Aged Mortality Nitrogen dioxide Nitrogen Dioxide - adverse effects Noise Outdoor air quality Particulate emissions Particulate matter Particulate Matter - adverse effects Pollution Pollution control Pollution dispersion Pollution levels Recall Reference Values Regression analysis Risk factors Risk reduction Studies Sulfur Systematic review VOCs Volatile organic compounds |
| title | Air Pollution and Glucose Metabolism: An Analysis in Non-Diabetic Participants of the Heinz Nixdorf Recall Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T20%3A02%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Air%20Pollution%20and%20Glucose%20Metabolism:%20An%20Analysis%20in%20Non-Diabetic%20Participants%20of%20the%20Heinz%20Nixdorf%20Recall%20Study&rft.jtitle=Environmental%20health%20perspectives&rft.au=Lucht,%20Sarah%20A&rft.date=2018-04-01&rft.volume=126&rft.issue=4&rft.spage=047001&rft.epage=047001&rft.pages=047001-047001&rft.issn=0091-6765&rft.eissn=1552-9924&rft_id=info:doi/10.1289/EHP2561&rft_dat=%3Cgale_pubme%3EA538714245%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2033374064&rft_id=info:pmid/29616776&rft_galeid=A538714245&rfr_iscdi=true |