A Novel Method for the Development of Environmental Public Health Indicators and Benchmark Dose Estimation Using a Health-Based End Point for Chlorpyrifos

Organophosphorus (OP) compounds are the most widely used group of insecticides in the world. Risk assessments for these chemicals have focused primarily on 10% inhibition of acetylcholinesterase in the brain as the critical metric of effect. Aside from cholinergic effects resulting from acute exposu...

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Veröffentlicht in:	Environmental health perspectives 2018-04, Vol.126 (4), p.047009
Hauptverfasser:	Zurlinden, Todd J, Reisfeld, Brad
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Analysis Animal cognition Animal models Animals Benchmarking Benchmarks Biomarkers Bone mineral density Brain Chemical properties Chlorpyrifos Chlorpyrifos - pharmacokinetics Chlorpyrifos - pharmacology Chlorpyrifos - toxicity Cognition Cognitive ability Cognitive Dysfunction - chemically induced Computer simulation Dose-Response Relationship, Drug Dosimetry Environmental Health - methods Environmental protection Equivalence Exposure Gene expression Hazardous substances risk assessment Health risk assessment Health risks Human-environment interactions Humans Indicators Information processing Insecticides Insecticides - pharmacokinetics Insecticides - pharmacology Insecticides - toxicity Memory Memory tasks Methods Models, Biological Neurosciences Occupational exposure Occupational health Organic phosphorus compounds Pesticides Pharmacodynamics Pharmacokinetics Pharmacology Predictions Proof of Concept Study Public health Public Health - methods Rats Risk assessment Rodents Spatial analysis Spatial memory Toxicity
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