N -Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK

NF-κB-inducing kinase (NIK), an oncogenic drug target that is associated with various cancers, is a central signalling component of the non-canonical pathway. A blind screening process, which established that amino pyrazole related scaffolds have an effect on IKKbeta, led to a optimization process t...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	MedChemComm 2018, Vol.9 (6), p.963-968
Hauptverfasser:	Pippione, Agnese C, Sainas, Stefano, Federico, Antonella, Lupino, Elisa, Piccinini, Marco, Kubbutat, Michael, Contreras, Jean-Marie, Morice, Christophe, Barge, Alessandro, Ducime, Alex, Boschi, Donatella, Al-Karadaghi, Salam, Lolli, Marco L
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry NF-κB protein Optimization Pyrazole Signal transduction Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!