Genomic Landscapes of EBV-Associated Nasopharyngeal Carcinoma vs. HPV-Associated Head and Neck Cancer
Epstein-Barr virus-positive nasopharyngeal carcinoma (EBV(+) NPC), and human papillomavirus-positive head and neck squamous cell carcinoma (HPV(+) HNSCC) are two distinct types of aggressive head and neck cancers with early age onsets. Their recently identified genomic landscapes by whole-exome sequ...
Gespeichert in:
| Veröffentlicht in: | Cancers 2018-06, Vol.10 (7), p.210 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 7 |
| container_start_page | 210 |
| container_title | Cancers |
| container_volume | 10 |
| creator | Ngan, Hoi-Lam Wang, Lan Lo, Kwok-Wai Lui, Vivian Wai Yan |
| description | Epstein-Barr virus-positive nasopharyngeal carcinoma (EBV(+) NPC), and human papillomavirus-positive head and neck squamous cell carcinoma (HPV(+) HNSCC) are two distinct types of aggressive head and neck cancers with early age onsets. Their recently identified genomic landscapes by whole-exome sequencing (WES) clearly reveal critical roles of: (1) inflammation via NF-kB activation, (2) survival via PI3K aberrations, and perhaps (3) immune evasion via MHC loss in these cancers as summarized in this review. Immediate outcomes of these WES studies include the identification of potential prognostic biomarkers, and druggable events for these cancers. The impact of these genomic findings on the development of precision medicine and immunotherapies will be discussed. For both of these cancers, the main lethality comes from metastases and disease recurrences which may represent therapy resistance. Thus, potential curing of these cancers still relies on future identification of key genomic drivers and likely druggable events in recurrent and metastatic forms of these intrinsically aggressive cancers of the head and neck. |
| doi_str_mv | 10.3390/cancers10070210 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6070978</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2108398676</sourcerecordid><originalsourceid>FETCH-LOGICAL-c487t-6408c380a3d316ed2a87c09855ac60b3549eee35283c428aba8860702efc010d3</originalsourceid><addsrcrecordid>eNpdkUFLAzEQhYMoWtSzNwl48bI6u9nNJhehFrVCqR7Ua5hmp7p1u6lJW_Dfm2KVtnPJQL55vMdj7CyFKyE0XFtsLfmQApSQpbDHOhmUWSKlzvc39iN2GsIE4giRlrI8ZEeZ1kJIITuMHqh109ryAbZVsDijwN2Y392-Jd0QnK1xThUfYnCzD_Tf7Tthw3vobR3PkC_DFe8_b7F9wopHMT4k-xnRlccTdjDGJtDp-j1mr_d3L71-Mnh6eOx1B4nNVTlPZA7KCgUoKpFKqjJUpQWtigKthJEock1EosiUsHmmcIRKyVV4GltIoRLH7OZXd7YYTamy1M49Nmbm62k0bxzWZvunrT_Mu1ualYouVRS4XAt497WgMDfTOlhqGmzJLYLJoFAFSA06ohc76MQtfBvjmViGElrJUkbq-pey3oXgafxvJgWzatHstBgvzjcz_PN_nYkfukGYgQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2108398676</pqid></control><display><type>article</type><title>Genomic Landscapes of EBV-Associated Nasopharyngeal Carcinoma vs. HPV-Associated Head and Neck Cancer</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Ngan, Hoi-Lam ; Wang, Lan ; Lo, Kwok-Wai ; Lui, Vivian Wai Yan</creator><creatorcontrib>Ngan, Hoi-Lam ; Wang, Lan ; Lo, Kwok-Wai ; Lui, Vivian Wai Yan</creatorcontrib><description>Epstein-Barr virus-positive nasopharyngeal carcinoma (EBV(+) NPC), and human papillomavirus-positive head and neck squamous cell carcinoma (HPV(+) HNSCC) are two distinct types of aggressive head and neck cancers with early age onsets. Their recently identified genomic landscapes by whole-exome sequencing (WES) clearly reveal critical roles of: (1) inflammation via NF-kB activation, (2) survival via PI3K aberrations, and perhaps (3) immune evasion via MHC loss in these cancers as summarized in this review. Immediate outcomes of these WES studies include the identification of potential prognostic biomarkers, and druggable events for these cancers. The impact of these genomic findings on the development of precision medicine and immunotherapies will be discussed. For both of these cancers, the main lethality comes from metastases and disease recurrences which may represent therapy resistance. Thus, potential curing of these cancers still relies on future identification of key genomic drivers and likely druggable events in recurrent and metastatic forms of these intrinsically aggressive cancers of the head and neck.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers10070210</identifier><identifier>PMID: 29933636</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>1-Phosphatidylinositol 3-kinase ; Epstein-Barr virus ; Head & neck cancer ; Human papillomavirus ; Immunotherapy ; Lethality ; Major histocompatibility complex ; Metastases ; Nasopharyngeal carcinoma ; Neck ; NF-κB protein ; Precision medicine ; Review ; Squamous cell carcinoma</subject><ispartof>Cancers, 2018-06, Vol.10 (7), p.210</ispartof><rights>2018. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 by the authors. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-6408c380a3d316ed2a87c09855ac60b3549eee35283c428aba8860702efc010d3</citedby><cites>FETCH-LOGICAL-c487t-6408c380a3d316ed2a87c09855ac60b3549eee35283c428aba8860702efc010d3</cites><orcidid>0000-0002-3488-6124</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070978/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070978/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29933636$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ngan, Hoi-Lam</creatorcontrib><creatorcontrib>Wang, Lan</creatorcontrib><creatorcontrib>Lo, Kwok-Wai</creatorcontrib><creatorcontrib>Lui, Vivian Wai Yan</creatorcontrib><title>Genomic Landscapes of EBV-Associated Nasopharyngeal Carcinoma vs. HPV-Associated Head and Neck Cancer</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>Epstein-Barr virus-positive nasopharyngeal carcinoma (EBV(+) NPC), and human papillomavirus-positive head and neck squamous cell carcinoma (HPV(+) HNSCC) are two distinct types of aggressive head and neck cancers with early age onsets. Their recently identified genomic landscapes by whole-exome sequencing (WES) clearly reveal critical roles of: (1) inflammation via NF-kB activation, (2) survival via PI3K aberrations, and perhaps (3) immune evasion via MHC loss in these cancers as summarized in this review. Immediate outcomes of these WES studies include the identification of potential prognostic biomarkers, and druggable events for these cancers. The impact of these genomic findings on the development of precision medicine and immunotherapies will be discussed. For both of these cancers, the main lethality comes from metastases and disease recurrences which may represent therapy resistance. Thus, potential curing of these cancers still relies on future identification of key genomic drivers and likely druggable events in recurrent and metastatic forms of these intrinsically aggressive cancers of the head and neck.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>Epstein-Barr virus</subject><subject>Head & neck cancer</subject><subject>Human papillomavirus</subject><subject>Immunotherapy</subject><subject>Lethality</subject><subject>Major histocompatibility complex</subject><subject>Metastases</subject><subject>Nasopharyngeal carcinoma</subject><subject>Neck</subject><subject>NF-κB protein</subject><subject>Precision medicine</subject><subject>Review</subject><subject>Squamous cell carcinoma</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkUFLAzEQhYMoWtSzNwl48bI6u9nNJhehFrVCqR7Ua5hmp7p1u6lJW_Dfm2KVtnPJQL55vMdj7CyFKyE0XFtsLfmQApSQpbDHOhmUWSKlzvc39iN2GsIE4giRlrI8ZEeZ1kJIITuMHqh109ryAbZVsDijwN2Y392-Jd0QnK1xThUfYnCzD_Tf7Tthw3vobR3PkC_DFe8_b7F9wopHMT4k-xnRlccTdjDGJtDp-j1mr_d3L71-Mnh6eOx1B4nNVTlPZA7KCgUoKpFKqjJUpQWtigKthJEock1EosiUsHmmcIRKyVV4GltIoRLH7OZXd7YYTamy1M49Nmbm62k0bxzWZvunrT_Mu1ualYouVRS4XAt497WgMDfTOlhqGmzJLYLJoFAFSA06ohc76MQtfBvjmViGElrJUkbq-pey3oXgafxvJgWzatHstBgvzjcz_PN_nYkfukGYgQ</recordid><startdate>20180621</startdate><enddate>20180621</enddate><creator>Ngan, Hoi-Lam</creator><creator>Wang, Lan</creator><creator>Lo, Kwok-Wai</creator><creator>Lui, Vivian Wai Yan</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3488-6124</orcidid></search><sort><creationdate>20180621</creationdate><title>Genomic Landscapes of EBV-Associated Nasopharyngeal Carcinoma vs. HPV-Associated Head and Neck Cancer</title><author>Ngan, Hoi-Lam ; Wang, Lan ; Lo, Kwok-Wai ; Lui, Vivian Wai Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-6408c380a3d316ed2a87c09855ac60b3549eee35283c428aba8860702efc010d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>1-Phosphatidylinositol 3-kinase</topic><topic>Epstein-Barr virus</topic><topic>Head & neck cancer</topic><topic>Human papillomavirus</topic><topic>Immunotherapy</topic><topic>Lethality</topic><topic>Major histocompatibility complex</topic><topic>Metastases</topic><topic>Nasopharyngeal carcinoma</topic><topic>Neck</topic><topic>NF-κB protein</topic><topic>Precision medicine</topic><topic>Review</topic><topic>Squamous cell carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ngan, Hoi-Lam</creatorcontrib><creatorcontrib>Wang, Lan</creatorcontrib><creatorcontrib>Lo, Kwok-Wai</creatorcontrib><creatorcontrib>Lui, Vivian Wai Yan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ngan, Hoi-Lam</au><au>Wang, Lan</au><au>Lo, Kwok-Wai</au><au>Lui, Vivian Wai Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genomic Landscapes of EBV-Associated Nasopharyngeal Carcinoma vs. HPV-Associated Head and Neck Cancer</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2018-06-21</date><risdate>2018</risdate><volume>10</volume><issue>7</issue><spage>210</spage><pages>210-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Epstein-Barr virus-positive nasopharyngeal carcinoma (EBV(+) NPC), and human papillomavirus-positive head and neck squamous cell carcinoma (HPV(+) HNSCC) are two distinct types of aggressive head and neck cancers with early age onsets. Their recently identified genomic landscapes by whole-exome sequencing (WES) clearly reveal critical roles of: (1) inflammation via NF-kB activation, (2) survival via PI3K aberrations, and perhaps (3) immune evasion via MHC loss in these cancers as summarized in this review. Immediate outcomes of these WES studies include the identification of potential prognostic biomarkers, and druggable events for these cancers. The impact of these genomic findings on the development of precision medicine and immunotherapies will be discussed. For both of these cancers, the main lethality comes from metastases and disease recurrences which may represent therapy resistance. Thus, potential curing of these cancers still relies on future identification of key genomic drivers and likely druggable events in recurrent and metastatic forms of these intrinsically aggressive cancers of the head and neck.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>29933636</pmid><doi>10.3390/cancers10070210</doi><orcidid>https://orcid.org/0000-0002-3488-6124</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2072-6694 |
| ispartof | Cancers, 2018-06, Vol.10 (7), p.210 |
| issn | 2072-6694 2072-6694 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6070978 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | 1-Phosphatidylinositol 3-kinase Epstein-Barr virus Head & neck cancer Human papillomavirus Immunotherapy Lethality Major histocompatibility complex Metastases Nasopharyngeal carcinoma Neck NF-κB protein Precision medicine Review Squamous cell carcinoma |
| title | Genomic Landscapes of EBV-Associated Nasopharyngeal Carcinoma vs. HPV-Associated Head and Neck Cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T23%3A18%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genomic%20Landscapes%20of%20EBV-Associated%20Nasopharyngeal%20Carcinoma%20vs.%20HPV-Associated%20Head%20and%20Neck%20Cancer&rft.jtitle=Cancers&rft.au=Ngan,%20Hoi-Lam&rft.date=2018-06-21&rft.volume=10&rft.issue=7&rft.spage=210&rft.pages=210-&rft.issn=2072-6694&rft.eissn=2072-6694&rft_id=info:doi/10.3390/cancers10070210&rft_dat=%3Cproquest_pubme%3E2108398676%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2108398676&rft_id=info:pmid/29933636&rfr_iscdi=true |