Rsad2 is necessary for mouse dendritic cell maturation via the IRF7-mediated signaling pathway
Dendritic cells (DCs) are the most potent professional antigen presenting cells and inducers of T cell-mediated immunity. However, few specific markers of mature DCs (mDC) have been reported. A previous microarray analysis revealed expression of mDC-specific genes and identified Rsad2 (radical S -ad...
Gespeichert in:
| Veröffentlicht in: | Cell death & disease 2018-08, Vol.9 (8), p.823-11, Article 823 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 11 |
|---|---|
| container_issue | 8 |
| container_start_page | 823 |
| container_title | Cell death & disease |
| container_volume | 9 |
| creator | Jang, Ji-Su Lee, Jun-Ho Jung, Nam-Chul Choi, So-Yeon Park, Soo-Yeoun Yoo, Ji-Young Song, Jie-Young Seo, Han Geuk Lee, Hyun Soo Lim, Dae-Seog |
| description | Dendritic cells (DCs) are the most potent professional antigen presenting cells and inducers of T cell-mediated immunity. However, few specific markers of mature DCs (mDC) have been reported. A previous microarray analysis revealed expression of mDC-specific genes and identified
Rsad2
(radical
S
-adenosyl methionine domain containing 2) as a candidate specific marker for DC maturation. Mouse bone marrow-derived DCs were transfected with
Rsad2
siRNA and examined by flow cytometry, ELISA, western, and confocal microscopy. C57BL/6 mice received intravenously B16F10 cells to establish a pulmonary metastasis model. Tumor-bearing mice then received subcutaneously two injections of mDCs or
Rsad2
knockdown DCs. The cytotoxic T lymphocyte (CTL) population was examined from splenocytes of DC-vaccinated mice by flow cytometry.
Rsad2
was induced at high levels in LPS-stimulated mDCs and mDC function was markedly attenuated under conditions of
Rsad2
knockdown. Moreover,
Rsad2
was necessary for mDC maturation via the IRF7-mediated signaling pathway. The importance of
Rsad2
was confirmed in an
Rsad2
knockdown lung metastasis mouse model in which mDCs lost their antitumor efficacy. Data on the CTL population further supported the results as above. Taken together,
Rsad2
was an obvious and specific marker necessary for DC maturation and these findings will be clearly helpful for further understanding of DC biology. |
| doi_str_mv | 10.1038/s41419-018-0889-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6070531</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2081527162</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-bc6080f5f41de99ff2f09ac56259545d92870ac88e34ec4b3428765e4a4ea1863</originalsourceid><addsrcrecordid>eNp1kV1rFDEUhoMottT-AG8k4I03U0--ZpIbQYq1hYJQ9NaQzZzZTZnJrEmmsv_ebLfWKpibfD3nzXnzEvKawRkDod9nySQzDTDdgNam2T0jxxwka2TdPX-yPiKnOd9CHUIAV-1LciQAWm20OSbfb7LrOQ2ZRvSYs0s7OsyJTvOSkfYY-xRK8NTjONLJlSW5EuZI74KjZYP06uaiaybsgyvY0xzW0Y0hrunWlc1Pt3tFXgxuzHj6MJ-Qbxefvp5fNtdfPl-df7xuvOygNCvfgoZBDZL1aMww8AGM86rlyiipesN1B85rjUKilysh60GrUDqJjulWnJAPB93tsqrdeIwludFuU5iqIzu7YP--iWFj1_OdbaEDJVgVePcgkOYfC-Zip5D3pl3E-hWWg-ZgQLS8om__QW_nJVXf9xRTvGP3FDtQPs05Jxwem2Fg9wHaQ4C2Bmj3AdpdrXnz1MVjxe-4KsAPQK5XcY3pz9P_V_0FHQWm8g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2081527162</pqid></control><display><type>article</type><title>Rsad2 is necessary for mouse dendritic cell maturation via the IRF7-mediated signaling pathway</title><source>Nature Free</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Springer Nature OA Free Journals</source><creator>Jang, Ji-Su ; Lee, Jun-Ho ; Jung, Nam-Chul ; Choi, So-Yeon ; Park, Soo-Yeoun ; Yoo, Ji-Young ; Song, Jie-Young ; Seo, Han Geuk ; Lee, Hyun Soo ; Lim, Dae-Seog</creator><creatorcontrib>Jang, Ji-Su ; Lee, Jun-Ho ; Jung, Nam-Chul ; Choi, So-Yeon ; Park, Soo-Yeoun ; Yoo, Ji-Young ; Song, Jie-Young ; Seo, Han Geuk ; Lee, Hyun Soo ; Lim, Dae-Seog</creatorcontrib><description>Dendritic cells (DCs) are the most potent professional antigen presenting cells and inducers of T cell-mediated immunity. However, few specific markers of mature DCs (mDC) have been reported. A previous microarray analysis revealed expression of mDC-specific genes and identified
Rsad2
(radical
S
-adenosyl methionine domain containing 2) as a candidate specific marker for DC maturation. Mouse bone marrow-derived DCs were transfected with
Rsad2
siRNA and examined by flow cytometry, ELISA, western, and confocal microscopy. C57BL/6 mice received intravenously B16F10 cells to establish a pulmonary metastasis model. Tumor-bearing mice then received subcutaneously two injections of mDCs or
Rsad2
knockdown DCs. The cytotoxic T lymphocyte (CTL) population was examined from splenocytes of DC-vaccinated mice by flow cytometry.
Rsad2
was induced at high levels in LPS-stimulated mDCs and mDC function was markedly attenuated under conditions of
Rsad2
knockdown. Moreover,
Rsad2
was necessary for mDC maturation via the IRF7-mediated signaling pathway. The importance of
Rsad2
was confirmed in an
Rsad2
knockdown lung metastasis mouse model in which mDCs lost their antitumor efficacy. Data on the CTL population further supported the results as above. Taken together,
Rsad2
was an obvious and specific marker necessary for DC maturation and these findings will be clearly helpful for further understanding of DC biology.</description><identifier>ISSN: 2041-4889</identifier><identifier>EISSN: 2041-4889</identifier><identifier>DOI: 10.1038/s41419-018-0889-y</identifier><identifier>PMID: 30068989</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/21 ; 13/31 ; 13/95 ; 14 ; 14/19 ; Antibodies ; Antigen-presenting cells ; Antitumor activity ; Biochemistry ; Biomedical and Life Sciences ; Bone marrow ; Cell Biology ; Cell Culture ; Cell-mediated immunity ; Confocal microscopy ; Cytotoxicity ; Dendritic cells ; Enzyme-linked immunosorbent assay ; Flow cytometry ; Immunology ; Interferon regulatory factor 7 ; Life Sciences ; Lipopolysaccharides ; Lung cancer ; Lymphocytes T ; Metastases ; Metastasis ; Methionine ; Rodents ; Signal transduction ; siRNA ; Splenocytes ; Vaccination</subject><ispartof>Cell death & disease, 2018-08, Vol.9 (8), p.823-11, Article 823</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-bc6080f5f41de99ff2f09ac56259545d92870ac88e34ec4b3428765e4a4ea1863</citedby><cites>FETCH-LOGICAL-c470t-bc6080f5f41de99ff2f09ac56259545d92870ac88e34ec4b3428765e4a4ea1863</cites><orcidid>0000-0003-2434-7511</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070531/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070531/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30068989$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jang, Ji-Su</creatorcontrib><creatorcontrib>Lee, Jun-Ho</creatorcontrib><creatorcontrib>Jung, Nam-Chul</creatorcontrib><creatorcontrib>Choi, So-Yeon</creatorcontrib><creatorcontrib>Park, Soo-Yeoun</creatorcontrib><creatorcontrib>Yoo, Ji-Young</creatorcontrib><creatorcontrib>Song, Jie-Young</creatorcontrib><creatorcontrib>Seo, Han Geuk</creatorcontrib><creatorcontrib>Lee, Hyun Soo</creatorcontrib><creatorcontrib>Lim, Dae-Seog</creatorcontrib><title>Rsad2 is necessary for mouse dendritic cell maturation via the IRF7-mediated signaling pathway</title><title>Cell death & disease</title><addtitle>Cell Death Dis</addtitle><addtitle>Cell Death Dis</addtitle><description>Dendritic cells (DCs) are the most potent professional antigen presenting cells and inducers of T cell-mediated immunity. However, few specific markers of mature DCs (mDC) have been reported. A previous microarray analysis revealed expression of mDC-specific genes and identified
Rsad2
(radical
S
-adenosyl methionine domain containing 2) as a candidate specific marker for DC maturation. Mouse bone marrow-derived DCs were transfected with
Rsad2
siRNA and examined by flow cytometry, ELISA, western, and confocal microscopy. C57BL/6 mice received intravenously B16F10 cells to establish a pulmonary metastasis model. Tumor-bearing mice then received subcutaneously two injections of mDCs or
Rsad2
knockdown DCs. The cytotoxic T lymphocyte (CTL) population was examined from splenocytes of DC-vaccinated mice by flow cytometry.
Rsad2
was induced at high levels in LPS-stimulated mDCs and mDC function was markedly attenuated under conditions of
Rsad2
knockdown. Moreover,
Rsad2
was necessary for mDC maturation via the IRF7-mediated signaling pathway. The importance of
Rsad2
was confirmed in an
Rsad2
knockdown lung metastasis mouse model in which mDCs lost their antitumor efficacy. Data on the CTL population further supported the results as above. Taken together,
Rsad2
was an obvious and specific marker necessary for DC maturation and these findings will be clearly helpful for further understanding of DC biology.</description><subject>13/21</subject><subject>13/31</subject><subject>13/95</subject><subject>14</subject><subject>14/19</subject><subject>Antibodies</subject><subject>Antigen-presenting cells</subject><subject>Antitumor activity</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Bone marrow</subject><subject>Cell Biology</subject><subject>Cell Culture</subject><subject>Cell-mediated immunity</subject><subject>Confocal microscopy</subject><subject>Cytotoxicity</subject><subject>Dendritic cells</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Flow cytometry</subject><subject>Immunology</subject><subject>Interferon regulatory factor 7</subject><subject>Life Sciences</subject><subject>Lipopolysaccharides</subject><subject>Lung cancer</subject><subject>Lymphocytes T</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Methionine</subject><subject>Rodents</subject><subject>Signal transduction</subject><subject>siRNA</subject><subject>Splenocytes</subject><subject>Vaccination</subject><issn>2041-4889</issn><issn>2041-4889</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kV1rFDEUhoMottT-AG8k4I03U0--ZpIbQYq1hYJQ9NaQzZzZTZnJrEmmsv_ebLfWKpibfD3nzXnzEvKawRkDod9nySQzDTDdgNam2T0jxxwka2TdPX-yPiKnOd9CHUIAV-1LciQAWm20OSbfb7LrOQ2ZRvSYs0s7OsyJTvOSkfYY-xRK8NTjONLJlSW5EuZI74KjZYP06uaiaybsgyvY0xzW0Y0hrunWlc1Pt3tFXgxuzHj6MJ-Qbxefvp5fNtdfPl-df7xuvOygNCvfgoZBDZL1aMww8AGM86rlyiipesN1B85rjUKilysh60GrUDqJjulWnJAPB93tsqrdeIwludFuU5iqIzu7YP--iWFj1_OdbaEDJVgVePcgkOYfC-Zip5D3pl3E-hWWg-ZgQLS8om__QW_nJVXf9xRTvGP3FDtQPs05Jxwem2Fg9wHaQ4C2Bmj3AdpdrXnz1MVjxe-4KsAPQK5XcY3pz9P_V_0FHQWm8g</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Jang, Ji-Su</creator><creator>Lee, Jun-Ho</creator><creator>Jung, Nam-Chul</creator><creator>Choi, So-Yeon</creator><creator>Park, Soo-Yeoun</creator><creator>Yoo, Ji-Young</creator><creator>Song, Jie-Young</creator><creator>Seo, Han Geuk</creator><creator>Lee, Hyun Soo</creator><creator>Lim, Dae-Seog</creator><general>Nature Publishing Group UK</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2434-7511</orcidid></search><sort><creationdate>20180801</creationdate><title>Rsad2 is necessary for mouse dendritic cell maturation via the IRF7-mediated signaling pathway</title><author>Jang, Ji-Su ; Lee, Jun-Ho ; Jung, Nam-Chul ; Choi, So-Yeon ; Park, Soo-Yeoun ; Yoo, Ji-Young ; Song, Jie-Young ; Seo, Han Geuk ; Lee, Hyun Soo ; Lim, Dae-Seog</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-bc6080f5f41de99ff2f09ac56259545d92870ac88e34ec4b3428765e4a4ea1863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>13/21</topic><topic>13/31</topic><topic>13/95</topic><topic>14</topic><topic>14/19</topic><topic>Antibodies</topic><topic>Antigen-presenting cells</topic><topic>Antitumor activity</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Bone marrow</topic><topic>Cell Biology</topic><topic>Cell Culture</topic><topic>Cell-mediated immunity</topic><topic>Confocal microscopy</topic><topic>Cytotoxicity</topic><topic>Dendritic cells</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Flow cytometry</topic><topic>Immunology</topic><topic>Interferon regulatory factor 7</topic><topic>Life Sciences</topic><topic>Lipopolysaccharides</topic><topic>Lung cancer</topic><topic>Lymphocytes T</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Methionine</topic><topic>Rodents</topic><topic>Signal transduction</topic><topic>siRNA</topic><topic>Splenocytes</topic><topic>Vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jang, Ji-Su</creatorcontrib><creatorcontrib>Lee, Jun-Ho</creatorcontrib><creatorcontrib>Jung, Nam-Chul</creatorcontrib><creatorcontrib>Choi, So-Yeon</creatorcontrib><creatorcontrib>Park, Soo-Yeoun</creatorcontrib><creatorcontrib>Yoo, Ji-Young</creatorcontrib><creatorcontrib>Song, Jie-Young</creatorcontrib><creatorcontrib>Seo, Han Geuk</creatorcontrib><creatorcontrib>Lee, Hyun Soo</creatorcontrib><creatorcontrib>Lim, Dae-Seog</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell death & disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jang, Ji-Su</au><au>Lee, Jun-Ho</au><au>Jung, Nam-Chul</au><au>Choi, So-Yeon</au><au>Park, Soo-Yeoun</au><au>Yoo, Ji-Young</au><au>Song, Jie-Young</au><au>Seo, Han Geuk</au><au>Lee, Hyun Soo</au><au>Lim, Dae-Seog</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rsad2 is necessary for mouse dendritic cell maturation via the IRF7-mediated signaling pathway</atitle><jtitle>Cell death & disease</jtitle><stitle>Cell Death Dis</stitle><addtitle>Cell Death Dis</addtitle><date>2018-08-01</date><risdate>2018</risdate><volume>9</volume><issue>8</issue><spage>823</spage><epage>11</epage><pages>823-11</pages><artnum>823</artnum><issn>2041-4889</issn><eissn>2041-4889</eissn><abstract>Dendritic cells (DCs) are the most potent professional antigen presenting cells and inducers of T cell-mediated immunity. However, few specific markers of mature DCs (mDC) have been reported. A previous microarray analysis revealed expression of mDC-specific genes and identified
Rsad2
(radical
S
-adenosyl methionine domain containing 2) as a candidate specific marker for DC maturation. Mouse bone marrow-derived DCs were transfected with
Rsad2
siRNA and examined by flow cytometry, ELISA, western, and confocal microscopy. C57BL/6 mice received intravenously B16F10 cells to establish a pulmonary metastasis model. Tumor-bearing mice then received subcutaneously two injections of mDCs or
Rsad2
knockdown DCs. The cytotoxic T lymphocyte (CTL) population was examined from splenocytes of DC-vaccinated mice by flow cytometry.
Rsad2
was induced at high levels in LPS-stimulated mDCs and mDC function was markedly attenuated under conditions of
Rsad2
knockdown. Moreover,
Rsad2
was necessary for mDC maturation via the IRF7-mediated signaling pathway. The importance of
Rsad2
was confirmed in an
Rsad2
knockdown lung metastasis mouse model in which mDCs lost their antitumor efficacy. Data on the CTL population further supported the results as above. Taken together,
Rsad2
was an obvious and specific marker necessary for DC maturation and these findings will be clearly helpful for further understanding of DC biology.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30068989</pmid><doi>10.1038/s41419-018-0889-y</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-2434-7511</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2041-4889 |
| ispartof | Cell death & disease, 2018-08, Vol.9 (8), p.823-11, Article 823 |
| issn | 2041-4889 2041-4889 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6070531 |
| source | Nature Free; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Springer Nature OA Free Journals |
| subjects | 13/21 13/31 13/95 14 14/19 Antibodies Antigen-presenting cells Antitumor activity Biochemistry Biomedical and Life Sciences Bone marrow Cell Biology Cell Culture Cell-mediated immunity Confocal microscopy Cytotoxicity Dendritic cells Enzyme-linked immunosorbent assay Flow cytometry Immunology Interferon regulatory factor 7 Life Sciences Lipopolysaccharides Lung cancer Lymphocytes T Metastases Metastasis Methionine Rodents Signal transduction siRNA Splenocytes Vaccination |
| title | Rsad2 is necessary for mouse dendritic cell maturation via the IRF7-mediated signaling pathway |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T15%3A31%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Rsad2%20is%20necessary%20for%20mouse%20dendritic%20cell%20maturation%20via%20the%20IRF7-mediated%20signaling%20pathway&rft.jtitle=Cell%20death%20&%20disease&rft.au=Jang,%20Ji-Su&rft.date=2018-08-01&rft.volume=9&rft.issue=8&rft.spage=823&rft.epage=11&rft.pages=823-11&rft.artnum=823&rft.issn=2041-4889&rft.eissn=2041-4889&rft_id=info:doi/10.1038/s41419-018-0889-y&rft_dat=%3Cproquest_pubme%3E2081527162%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2081527162&rft_id=info:pmid/30068989&rfr_iscdi=true |