Evaluating protective and therapeutic effects of alpha-lipoic acid on cisplatin-induced ototoxicity

Cisplatin, a small platinum-containing molecule, is a widely used, highly effective anticancer drug. However, severe side effects have been found in cancer patients treated with cisplatin, including nephrotoxicity, neurotoxicity, and ototoxicity. These cisplatin-induced side effects can have a major...

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Veröffentlicht in:	Cell death & disease 2018-08, Vol.9 (8), p.827-13, Article 827
Hauptverfasser:	Kim, Kyung-Hee, Lee, Byeonghyeon, Kim, Ye-Ri, Kim, Min-A, Ryu, Nari, Jung, Da Jung, Kim, Un-Kyung, Baek, Jeong-In, Lee, Kyu-Yup
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 14/35 64/60 82/29 82/80 Antibodies Antioxidants Apoptosis Biochemistry Biomedical and Life Sciences Cancer Cell Biology Cell Culture Cell death Chemotherapy Cisplatin Cochlea Glutathione reductase Hearing loss Immunology Life Sciences Lipoic acid Mitochondria Neurotoxicity Ototoxicity Oxidative stress Patients Platinum Quality of life Reactive oxygen species Side effects
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