CD4 T cells in protection from influenza virus: Viral antigen specificity and functional potential

Summary CD4 T cells convey a number of discrete functions to protective immunity to influenza, a complexity that distinguishes this arm of adaptive immunity from B cells and CD8 T cells. Although the most well recognized function of CD4 T cells is provision of help for antibody production, CD4 T cel...

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Veröffentlicht in:	Immunological reviews 2018-07, Vol.284 (1), p.91-105
Hauptverfasser:	Sant, Andrea J., DiPiazza, Anthony T., Nayak, Jennifer L., Rattan, Ajitanuj, Richards, Katherine A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Animal models Animals Antibodies, Viral - immunology antigen Antigens Antigens, Viral - immunology B-Lymphocytes CD4 antigen CD4 T cells CD4-Positive T-Lymphocytes - immunology CD8 antigen Discrete functions Disease Models, Animal Epitopes Hemagglutinin Glycoproteins, Influenza Virus - immunology Human behavior human immunity Humans Immunity immunodominance Immunologic Memory - immunology Immunological memory Infections Influenza Influenza A Influenza A Virus, H1N1 Subtype - immunology Influenza, Human - immunology lung Lungs Lymphocytes Lymphocytes B Lymphocytes T Memory cells Mice Pandemics Strains (organisms) vaccine responses Vaccines Viruses
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