Vascular Compartmentalization of Functional Hyperemia from the Synapse to the Pia

Functional hyperemia, a regional increase of blood flow triggered by local neural activation, is used to map brain activity in health and disease. However, the spatial-temporal dynamics of functional hyperemia remain unclear. Two-photon imaging of the entire vascular arbor in NG2-creERT2;GCaMP6f mic...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2018-07, Vol.99 (2), p.362-375.e4
Hauptverfasser:	Rungta, Ravi L., Chaigneau, Emmanuelle, Osmanski, Bruno-Félix, Charpak, Serge
Format:	Artikel
Sprache:	eng
Schlagworte:	anesthetized Animals astrocyte awake Blood flow blood-brain barrier Brain - blood supply Brain - physiology Brain Chemistry - physiology Brain mapping calcium Calcium signalling Capillaries CBF endothelium functional imaging Functional magnetic resonance imaging gap junction glia glutamate Hyperemia Hyperemia - diagnosis Hyperemia - physiopathology hyperpolarization in vivo Mice Mice, Inbred C57BL Mice, Transgenic Microscopy, Confocal - methods microvascular Muscle, Smooth, Vascular - chemistry Muscle, Smooth, Vascular - physiology Neuroimaging neuron neurovascular coupling neurovascular unit odor Odors Pericytes Pericytes - chemistry Pericytes - physiology Pia Mater - blood supply Pia Mater - chemistry Pia Mater - physiology Smooth muscle Synapses Synapses - chemistry Synapses - physiology Velocity
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