Robotic radiosurgery treatment in liver tumors: Early experience from an Indian center
Abstract Purpose: The purpose of this study is to report CyberKnife experience in hepatocellular carcinoma (HCC) and liver metastasis (LM). Materials and Methods: Fifty liver lesions in 31 consecutive patients with liver lesion [mean age 54.5 years (range 32-81 years), 77% were male patient, GTV 90c...
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| Veröffentlicht in: | South Asian Journal of Cancer 2018-07, Vol.7 (3), p.175-182 |
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| creator | Dutta, Debnarayan Krishnamoorthy, Sathiya Sudahar, H. Muthukumaran, M. Ramkumar, T. Govindraj, Jayraj |
| description | Abstract
Purpose:
The purpose of this study is to report CyberKnife experience in hepatocellular carcinoma (HCC) and liver metastasis (LM).
Materials and Methods:
Fifty liver lesions in 31 consecutive patients with liver lesion [mean age 54.5 years (range 32-81 years), 77% were male patient, GTV 90cc in 8 patients respectively. Eighty percentage (25/31) had prior treatment (chemotherapy 18 patient & TACE in 7 patients). Dosage schedule was 21-45Gy/3# (mean PTV dose 33Gy, Prescription isodose 84%, target coverage 94%). Mean CI, nCI & HI were 1.19, 1.31 & 1.18 respectively. Mean liver dose was 5.4 Gy, 800 cc liver dose 11.1 Gy;
Results:
At mean follow-up of 12.5 months (range 1.9–44.6 months), 19 patients were expired and 12 were alive (nine patient with stable disease, two local progression, and one with metastasis). Median overall survival (OS) of all patients are 9 months (1.9–44.6 months), in HCC patients 10.5 months (2.1–44.6 months) and MT 6.5 months (1.9–24.6 months) respectively. Gr-I-II GI toxicities were in 11/50 (22%) patients. OS was influenced by PS (Karnofsky Performance Status 70–80 vs. 90–100: 9.9 vs. 16.4; P = 0.024), Child-Pugh (CP A/B vs. C: 23.6 vs. 6.5; P = 0.069), cirrhosis (only fatty liver vs. diffuse cirrhosis: 17.8 vs. 10.6; P = 0.003), prior treatment (no Rx vs. prior Rx: 30.1 vs. 8.2; P = 0.08), number of lesions (single vs. multiple: 16.4 vs. 6.9; P = 0.001), and target volume (90 cc: 24.6 vs. 11.2; P = 0.03).
Conclusion:
Stereotactic body radiation therapy is a safe and effective treatment. Patient related factors such as performance status, Child-Pugh classification, cirrhosis status, prior treatment, number of liver lesion & target volume (GTV) influence the survival functions. |
| doi_str_mv | 10.4103/sajc.sajc_19_18 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_doaj_</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6069331</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_e74405bc516241599450f0c4cb90c97a</doaj_id><sourcerecordid>30112334</sourcerecordid><originalsourceid>FETCH-LOGICAL-c565t-9b913e40bdc4c2dc4dcb66790eab0fd76c82d3f16dd897314417a4fb51d2effc3</originalsourceid><addsrcrecordid>eNp1kU9rGzEQxUVJaUKac29BX8C2tNJqVzkEQkhbQ6BQ2tKb0J-RI7O7MrPrEH_7ynGSJodcZoT03m8YPUK-cDaXnInFaNd-vi-Ga8PbD-Skqpp2JgVTR09nIdjfY3I2jmvGWPGIVvNP5Fgwzish5An58zO7PCVP0YaUxy2uAHd0QrBTD8NE00C7dA9Ip22fcbygNxa7HYWHDWCCwQONmHtqB7ocQirNFxfgZ_Ix2m6Es6d-Sn5_vfl1_X12--Pb8vrqduZrVU8z7TQXIJkLXvqqlOCdUo1mYB2LoVG-rYKIXIXQ6kZwKXljZXQ1DxXE6MUpWR64Idu12WDqLe5Mtsk8XmRcGYtlvQ4MNFKy2vmaq0ryWmtZs8jKXKeZ140trMsDa7N1PYT9Imi7N9C3L0O6M6t8bxRTWgheAIsDwGMeR4T44uXM7BMzj2H9T6w4zl-PfNE_51ME84NgukvQg1nnLQ7lQ98l_gM3eKY4</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Robotic radiosurgery treatment in liver tumors: Early experience from an Indian center</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><source>Thieme Connect Journals Open Access</source><creator>Dutta, Debnarayan ; Krishnamoorthy, Sathiya ; Sudahar, H. ; Muthukumaran, M. ; Ramkumar, T. ; Govindraj, Jayraj</creator><creatorcontrib>Dutta, Debnarayan ; Krishnamoorthy, Sathiya ; Sudahar, H. ; Muthukumaran, M. ; Ramkumar, T. ; Govindraj, Jayraj</creatorcontrib><description><![CDATA[Abstract
Purpose:
The purpose of this study is to report CyberKnife experience in hepatocellular carcinoma (HCC) and liver metastasis (LM).
Materials and Methods:
Fifty liver lesions in 31 consecutive patients with liver lesion [mean age 54.5 years (range 32-81 years), 77% were male patient, GTV <10cc in 5 patients, 11-90cc in 18 & >90cc in 8 patients respectively. Eighty percentage (25/31) had prior treatment (chemotherapy 18 patient & TACE in 7 patients). Dosage schedule was 21-45Gy/3# (mean PTV dose 33Gy, Prescription isodose 84%, target coverage 94%). Mean CI, nCI & HI were 1.19, 1.31 & 1.18 respectively. Mean liver dose was 5.4 Gy, 800 cc liver dose 11.1 Gy;
Results:
At mean follow-up of 12.5 months (range 1.9–44.6 months), 19 patients were expired and 12 were alive (nine patient with stable disease, two local progression, and one with metastasis). Median overall survival (OS) of all patients are 9 months (1.9–44.6 months), in HCC patients 10.5 months (2.1–44.6 months) and MT 6.5 months (1.9–24.6 months) respectively. Gr-I-II GI toxicities were in 11/50 (22%) patients. OS was influenced by PS (Karnofsky Performance Status 70–80 vs. 90–100: 9.9 vs. 16.4; P = 0.024), Child-Pugh (CP A/B vs. C: 23.6 vs. 6.5; P = 0.069), cirrhosis (only fatty liver vs. diffuse cirrhosis: 17.8 vs. 10.6; P = 0.003), prior treatment (no Rx vs. prior Rx: 30.1 vs. 8.2; P = 0.08), number of lesions (single vs. multiple: 16.4 vs. 6.9; P = 0.001), and target volume (<10 cc vs. >90 cc: 24.6 vs. 11.2; P = 0.03).
Conclusion:
Stereotactic body radiation therapy is a safe and effective treatment. Patient related factors such as performance status, Child-Pugh classification, cirrhosis status, prior treatment, number of liver lesion & target volume (GTV) influence the survival functions.]]></description><identifier>ISSN: 2278-330X</identifier><identifier>EISSN: 2278-4306</identifier><identifier>DOI: 10.4103/sajc.sajc_19_18</identifier><identifier>PMID: 30112334</identifier><language>eng</language><publisher>A-12, 2nd Floor, Sector 2, Noida-201301 UP, India: Thieme Medical and Scientific Publishers Pvt. Ltd</publisher><subject>CyberKnife ; Indian experience ; liver tumor ; ORIGINAL ARTICLE: Gastro-intestinal & Hepatobiliary Cancer ; robotic radiosurgery</subject><ispartof>South Asian Journal of Cancer, 2018-07, Vol.7 (3), p.175-182</ispartof><rights>MedIntel Services Pvt Ltd. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/.)</rights><rights>Copyright: © 2018 The South Asian Journal of Cancer 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-9b913e40bdc4c2dc4dcb66790eab0fd76c82d3f16dd897314417a4fb51d2effc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069331/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069331/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,20870,27901,27902,53766,53768,54562</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30112334$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dutta, Debnarayan</creatorcontrib><creatorcontrib>Krishnamoorthy, Sathiya</creatorcontrib><creatorcontrib>Sudahar, H.</creatorcontrib><creatorcontrib>Muthukumaran, M.</creatorcontrib><creatorcontrib>Ramkumar, T.</creatorcontrib><creatorcontrib>Govindraj, Jayraj</creatorcontrib><title>Robotic radiosurgery treatment in liver tumors: Early experience from an Indian center</title><title>South Asian Journal of Cancer</title><addtitle>South Asian J Cancer</addtitle><description><![CDATA[Abstract
Purpose:
The purpose of this study is to report CyberKnife experience in hepatocellular carcinoma (HCC) and liver metastasis (LM).
Materials and Methods:
Fifty liver lesions in 31 consecutive patients with liver lesion [mean age 54.5 years (range 32-81 years), 77% were male patient, GTV <10cc in 5 patients, 11-90cc in 18 & >90cc in 8 patients respectively. Eighty percentage (25/31) had prior treatment (chemotherapy 18 patient & TACE in 7 patients). Dosage schedule was 21-45Gy/3# (mean PTV dose 33Gy, Prescription isodose 84%, target coverage 94%). Mean CI, nCI & HI were 1.19, 1.31 & 1.18 respectively. Mean liver dose was 5.4 Gy, 800 cc liver dose 11.1 Gy;
Results:
At mean follow-up of 12.5 months (range 1.9–44.6 months), 19 patients were expired and 12 were alive (nine patient with stable disease, two local progression, and one with metastasis). Median overall survival (OS) of all patients are 9 months (1.9–44.6 months), in HCC patients 10.5 months (2.1–44.6 months) and MT 6.5 months (1.9–24.6 months) respectively. Gr-I-II GI toxicities were in 11/50 (22%) patients. OS was influenced by PS (Karnofsky Performance Status 70–80 vs. 90–100: 9.9 vs. 16.4; P = 0.024), Child-Pugh (CP A/B vs. C: 23.6 vs. 6.5; P = 0.069), cirrhosis (only fatty liver vs. diffuse cirrhosis: 17.8 vs. 10.6; P = 0.003), prior treatment (no Rx vs. prior Rx: 30.1 vs. 8.2; P = 0.08), number of lesions (single vs. multiple: 16.4 vs. 6.9; P = 0.001), and target volume (<10 cc vs. >90 cc: 24.6 vs. 11.2; P = 0.03).
Conclusion:
Stereotactic body radiation therapy is a safe and effective treatment. Patient related factors such as performance status, Child-Pugh classification, cirrhosis status, prior treatment, number of liver lesion & target volume (GTV) influence the survival functions.]]></description><subject>CyberKnife</subject><subject>Indian experience</subject><subject>liver tumor</subject><subject>ORIGINAL ARTICLE: Gastro-intestinal & Hepatobiliary Cancer</subject><subject>robotic radiosurgery</subject><issn>2278-330X</issn><issn>2278-4306</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>0U6</sourceid><sourceid>DOA</sourceid><recordid>eNp1kU9rGzEQxUVJaUKac29BX8C2tNJqVzkEQkhbQ6BQ2tKb0J-RI7O7MrPrEH_7ynGSJodcZoT03m8YPUK-cDaXnInFaNd-vi-Ga8PbD-Skqpp2JgVTR09nIdjfY3I2jmvGWPGIVvNP5Fgwzish5An58zO7PCVP0YaUxy2uAHd0QrBTD8NE00C7dA9Ip22fcbygNxa7HYWHDWCCwQONmHtqB7ocQirNFxfgZ_Ix2m6Es6d-Sn5_vfl1_X12--Pb8vrqduZrVU8z7TQXIJkLXvqqlOCdUo1mYB2LoVG-rYKIXIXQ6kZwKXljZXQ1DxXE6MUpWR64Idu12WDqLe5Mtsk8XmRcGYtlvQ4MNFKy2vmaq0ryWmtZs8jKXKeZ140trMsDa7N1PYT9Imi7N9C3L0O6M6t8bxRTWgheAIsDwGMeR4T44uXM7BMzj2H9T6w4zl-PfNE_51ME84NgukvQg1nnLQ7lQ98l_gM3eKY4</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Dutta, Debnarayan</creator><creator>Krishnamoorthy, Sathiya</creator><creator>Sudahar, H.</creator><creator>Muthukumaran, M.</creator><creator>Ramkumar, T.</creator><creator>Govindraj, Jayraj</creator><general>Thieme Medical and Scientific Publishers Pvt. Ltd</general><general>Medknow Publications & Media Pvt Ltd</general><scope>0U6</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20180701</creationdate><title>Robotic radiosurgery treatment in liver tumors: Early experience from an Indian center</title><author>Dutta, Debnarayan ; Krishnamoorthy, Sathiya ; Sudahar, H. ; Muthukumaran, M. ; Ramkumar, T. ; Govindraj, Jayraj</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c565t-9b913e40bdc4c2dc4dcb66790eab0fd76c82d3f16dd897314417a4fb51d2effc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>CyberKnife</topic><topic>Indian experience</topic><topic>liver tumor</topic><topic>ORIGINAL ARTICLE: Gastro-intestinal & Hepatobiliary Cancer</topic><topic>robotic radiosurgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dutta, Debnarayan</creatorcontrib><creatorcontrib>Krishnamoorthy, Sathiya</creatorcontrib><creatorcontrib>Sudahar, H.</creatorcontrib><creatorcontrib>Muthukumaran, M.</creatorcontrib><creatorcontrib>Ramkumar, T.</creatorcontrib><creatorcontrib>Govindraj, Jayraj</creatorcontrib><collection>Thieme Connect Journals Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>South Asian Journal of Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dutta, Debnarayan</au><au>Krishnamoorthy, Sathiya</au><au>Sudahar, H.</au><au>Muthukumaran, M.</au><au>Ramkumar, T.</au><au>Govindraj, Jayraj</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Robotic radiosurgery treatment in liver tumors: Early experience from an Indian center</atitle><jtitle>South Asian Journal of Cancer</jtitle><addtitle>South Asian J Cancer</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>7</volume><issue>3</issue><spage>175</spage><epage>182</epage><pages>175-182</pages><issn>2278-330X</issn><eissn>2278-4306</eissn><abstract><![CDATA[Abstract
Purpose:
The purpose of this study is to report CyberKnife experience in hepatocellular carcinoma (HCC) and liver metastasis (LM).
Materials and Methods:
Fifty liver lesions in 31 consecutive patients with liver lesion [mean age 54.5 years (range 32-81 years), 77% were male patient, GTV <10cc in 5 patients, 11-90cc in 18 & >90cc in 8 patients respectively. Eighty percentage (25/31) had prior treatment (chemotherapy 18 patient & TACE in 7 patients). Dosage schedule was 21-45Gy/3# (mean PTV dose 33Gy, Prescription isodose 84%, target coverage 94%). Mean CI, nCI & HI were 1.19, 1.31 & 1.18 respectively. Mean liver dose was 5.4 Gy, 800 cc liver dose 11.1 Gy;
Results:
At mean follow-up of 12.5 months (range 1.9–44.6 months), 19 patients were expired and 12 were alive (nine patient with stable disease, two local progression, and one with metastasis). Median overall survival (OS) of all patients are 9 months (1.9–44.6 months), in HCC patients 10.5 months (2.1–44.6 months) and MT 6.5 months (1.9–24.6 months) respectively. Gr-I-II GI toxicities were in 11/50 (22%) patients. OS was influenced by PS (Karnofsky Performance Status 70–80 vs. 90–100: 9.9 vs. 16.4; P = 0.024), Child-Pugh (CP A/B vs. C: 23.6 vs. 6.5; P = 0.069), cirrhosis (only fatty liver vs. diffuse cirrhosis: 17.8 vs. 10.6; P = 0.003), prior treatment (no Rx vs. prior Rx: 30.1 vs. 8.2; P = 0.08), number of lesions (single vs. multiple: 16.4 vs. 6.9; P = 0.001), and target volume (<10 cc vs. >90 cc: 24.6 vs. 11.2; P = 0.03).
Conclusion:
Stereotactic body radiation therapy is a safe and effective treatment. Patient related factors such as performance status, Child-Pugh classification, cirrhosis status, prior treatment, number of liver lesion & target volume (GTV) influence the survival functions.]]></abstract><cop>A-12, 2nd Floor, Sector 2, Noida-201301 UP, India</cop><pub>Thieme Medical and Scientific Publishers Pvt. Ltd</pub><pmid>30112334</pmid><doi>10.4103/sajc.sajc_19_18</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | CyberKnife Indian experience liver tumor ORIGINAL ARTICLE: Gastro-intestinal & Hepatobiliary Cancer robotic radiosurgery |
| title | Robotic radiosurgery treatment in liver tumors: Early experience from an Indian center |
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