Cancer cells copy migratory behavior and exchange signaling networks via extracellular vesicles

Recent data showed that cancer cells from different tumor subtypes with distinct metastatic potential influence each other's metastatic behavior by exchanging biomolecules through extracellular vesicles (EVs). However, it is debated how small amounts of cargo can mediate this effect, especially...

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Veröffentlicht in:	The EMBO journal 2018-08, Vol.37 (15), p.n/a
Hauptverfasser:	Steenbeek, Sander C, Pham, Thang V, de Ligt, Joep, Zomer, Anoek, Knol, Jaco C, Piersma, Sander R, Schelfhorst, Tim, Huisjes, Rick, Schiffelers, Raymond M, Cuppen, Edwin, Jimenez, Connie R, van Rheenen, Jacco
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomolecules Cancer Cell adhesion & migration Cell Line, Tumor Cell migration Cell Movement - physiology Cellular communication Cre‐LoxP EMBO03 EMBO20 EMBO31 Exchanging Extracellular vesicles Extracellular Vesicles - metabolism Gene expression Gene sequencing Heterogeneity In vivo methods and tests intratumoral heterogeneity intravital microscopy Invasiveness Mass spectrometry Mass spectroscopy Melanoma Melanoma, Experimental - pathology Metastases Metastasis Mice Microenvironments Microscopy Neoplasm Metastasis - pathology Proteins Proteomes Ribonucleic acid RNA RNA, Messenger - genetics Signal Transduction - physiology Signaling signaling networks Tumor Microenvironment - physiology Tumors Vesicles
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