Structural differences in the brain between wild and laboratory rats (Rattus norvegicus): Potential contribution to wariness
Wild animals typically exhibit defensive behaviors in response to a wider range and/or a weaker intensity of stimuli compared with domestic animals. However, little is known about the neural mechanisms underlying “wariness” in wild animals. Wild rats are one of the most accessible wild animals for e...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2018, Vol.80(7), pp.1054-1060 |
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| container_title | Journal of Veterinary Medical Science |
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| creator | KOIZUMI, Ryoko KIYOKAWA, Yasushi MIKAMI, Kaori ISHII, Akiko TANAKA, Kazuyuki D. TANIKAWA, Tsutomu TAKEUCHI, Yukari |
| description | Wild animals typically exhibit defensive behaviors in response to a wider range and/or a weaker intensity of stimuli compared with domestic animals. However, little is known about the neural mechanisms underlying “wariness” in wild animals. Wild rats are one of the most accessible wild animals for experimental research. Laboratory rats are a domesticated form of wild rat, belonging to the same species, and are therefore considered suitable control animals for wild rats. Based on these factors, we analyzed structural differences in the brain between wild and laboratory rats to elucidate the neural mechanisms underlying wariness. We examined wild rats trapped in Tokyo, and weight-matched laboratory rats. We then prepared brain sections and compared the basolateral complex of the amygdala (BLA), the bed nucleus of the stria terminalis (BNST), the main olfactory bulb and the accessory olfactory bulb. The results revealed that wild rats exhibited larger BLA, BNST and caudal part of the accessory olfactory bulb compared with laboratory rats. These results suggest that the BLA, BNST, and vomeronasal system potentially contribute to wariness in wild rats. |
| doi_str_mv | 10.1292/jvms.18-0052 |
| format | Article |
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However, little is known about the neural mechanisms underlying “wariness” in wild animals. Wild rats are one of the most accessible wild animals for experimental research. Laboratory rats are a domesticated form of wild rat, belonging to the same species, and are therefore considered suitable control animals for wild rats. Based on these factors, we analyzed structural differences in the brain between wild and laboratory rats to elucidate the neural mechanisms underlying wariness. We examined wild rats trapped in Tokyo, and weight-matched laboratory rats. We then prepared brain sections and compared the basolateral complex of the amygdala (BLA), the bed nucleus of the stria terminalis (BNST), the main olfactory bulb and the accessory olfactory bulb. The results revealed that wild rats exhibited larger BLA, BNST and caudal part of the accessory olfactory bulb compared with laboratory rats. These results suggest that the BLA, BNST, and vomeronasal system potentially contribute to wariness in wild rats.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.18-0052</identifier><identifier>PMID: 29760315</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>Accessory olfactory bulb ; Amygdala ; Animals ; Animals, Wild ; basolateral complex of the amygdala ; bed nucleus of the stria terminalis ; Brain ; Brain - physiology ; Brain - ultrastructure ; Defensive behavior ; Domestic animals ; Ethology ; Experimental research ; Female ; Laboratories ; main olfactory bulb ; Male ; Olfactory Bulb ; Rats ; Rodents ; Stria terminalis ; vomeronasal receptor ; Vomeronasal system</subject><ispartof>Journal of Veterinary Medical Science, 2018, Vol.80(7), pp.1054-1060</ispartof><rights>2018 by the Japanese Society of Veterinary Science</rights><rights>Copyright Japan Science and Technology Agency Jul 2018</rights><rights>2018 The Japanese Society of Veterinary Science 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c706t-37c8ee8da26badd2d57a7d2085df4d0575c85773e3a419b1fa62b982b4d083143</citedby><cites>FETCH-LOGICAL-c706t-37c8ee8da26badd2d57a7d2085df4d0575c85773e3a419b1fa62b982b4d083143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068309/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068309/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1883,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29760315$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOIZUMI, Ryoko</creatorcontrib><creatorcontrib>KIYOKAWA, Yasushi</creatorcontrib><creatorcontrib>MIKAMI, Kaori</creatorcontrib><creatorcontrib>ISHII, Akiko</creatorcontrib><creatorcontrib>TANAKA, Kazuyuki D.</creatorcontrib><creatorcontrib>TANIKAWA, Tsutomu</creatorcontrib><creatorcontrib>TAKEUCHI, Yukari</creatorcontrib><title>Structural differences in the brain between wild and laboratory rats (Rattus norvegicus): Potential contribution to wariness</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>Wild animals typically exhibit defensive behaviors in response to a wider range and/or a weaker intensity of stimuli compared with domestic animals. However, little is known about the neural mechanisms underlying “wariness” in wild animals. Wild rats are one of the most accessible wild animals for experimental research. Laboratory rats are a domesticated form of wild rat, belonging to the same species, and are therefore considered suitable control animals for wild rats. Based on these factors, we analyzed structural differences in the brain between wild and laboratory rats to elucidate the neural mechanisms underlying wariness. We examined wild rats trapped in Tokyo, and weight-matched laboratory rats. We then prepared brain sections and compared the basolateral complex of the amygdala (BLA), the bed nucleus of the stria terminalis (BNST), the main olfactory bulb and the accessory olfactory bulb. The results revealed that wild rats exhibited larger BLA, BNST and caudal part of the accessory olfactory bulb compared with laboratory rats. These results suggest that the BLA, BNST, and vomeronasal system potentially contribute to wariness in wild rats.</description><subject>Accessory olfactory bulb</subject><subject>Amygdala</subject><subject>Animals</subject><subject>Animals, Wild</subject><subject>basolateral complex of the amygdala</subject><subject>bed nucleus of the stria terminalis</subject><subject>Brain</subject><subject>Brain - physiology</subject><subject>Brain - ultrastructure</subject><subject>Defensive behavior</subject><subject>Domestic animals</subject><subject>Ethology</subject><subject>Experimental research</subject><subject>Female</subject><subject>Laboratories</subject><subject>main olfactory bulb</subject><subject>Male</subject><subject>Olfactory Bulb</subject><subject>Rats</subject><subject>Rodents</subject><subject>Stria terminalis</subject><subject>vomeronasal receptor</subject><subject>Vomeronasal system</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUuLFDEURoMoTju6cy0BNyNYYx5VScWFoIMvGFB8rEMqudWdpjqZSVLdDPjjTdNto25yA9_hcC8fQk8puaRMsVfr7SZf0r4hpGP30ILyVjay5eo-WhBFRSNZR87Qo5zXhDDaCvUQnTElBeG0W6Bf30uabZmTmbDz4wgJgoWMfcBlBXhIpv4GKDuAgHd-ctgEhyczxGRKTHe4jowvvplS5oxDTFtYejvnF6_x11ggFF_FNoaS_DAXH6s24p1JPkDOj9GD0UwZnhznOfr54f2Pq0_N9ZePn6_eXjdWElEaLm0P0DvDxGCcY66TRjpG-s6NrSOd7GzfScmBm5aqgY5GsEH1bKhhz2nLz9Gbg_dmHjbgbF2r3qtvkt-YdKej8frfJPiVXsatFkT0nKgquDgKUrydIRe98dnCNJkAcc6aEa6YIoSTij7_D13HOYV6nmaMK0FF2-2FLw-UTTHnBONpGUr0vla9r1XTXu9rrfizvw84wX96rMC7A7DOxSzhBJhUvJ3gYOuJlvvnaD2FdmWShsB_A6l6uXE</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>KOIZUMI, Ryoko</creator><creator>KIYOKAWA, Yasushi</creator><creator>MIKAMI, Kaori</creator><creator>ISHII, Akiko</creator><creator>TANAKA, Kazuyuki D.</creator><creator>TANIKAWA, Tsutomu</creator><creator>TAKEUCHI, Yukari</creator><general>JAPANESE SOCIETY OF VETERINARY SCIENCE</general><general>Japan Science and Technology Agency</general><general>The Japanese Society of Veterinary Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2018</creationdate><title>Structural differences in the brain between wild and laboratory rats (Rattus norvegicus): Potential contribution to wariness</title><author>KOIZUMI, Ryoko ; KIYOKAWA, Yasushi ; MIKAMI, Kaori ; ISHII, Akiko ; TANAKA, Kazuyuki D. ; TANIKAWA, Tsutomu ; TAKEUCHI, Yukari</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c706t-37c8ee8da26badd2d57a7d2085df4d0575c85773e3a419b1fa62b982b4d083143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Accessory olfactory bulb</topic><topic>Amygdala</topic><topic>Animals</topic><topic>Animals, Wild</topic><topic>basolateral complex of the amygdala</topic><topic>bed nucleus of the stria terminalis</topic><topic>Brain</topic><topic>Brain - physiology</topic><topic>Brain - ultrastructure</topic><topic>Defensive behavior</topic><topic>Domestic animals</topic><topic>Ethology</topic><topic>Experimental research</topic><topic>Female</topic><topic>Laboratories</topic><topic>main olfactory bulb</topic><topic>Male</topic><topic>Olfactory Bulb</topic><topic>Rats</topic><topic>Rodents</topic><topic>Stria terminalis</topic><topic>vomeronasal receptor</topic><topic>Vomeronasal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOIZUMI, Ryoko</creatorcontrib><creatorcontrib>KIYOKAWA, Yasushi</creatorcontrib><creatorcontrib>MIKAMI, Kaori</creatorcontrib><creatorcontrib>ISHII, Akiko</creatorcontrib><creatorcontrib>TANAKA, Kazuyuki D.</creatorcontrib><creatorcontrib>TANIKAWA, Tsutomu</creatorcontrib><creatorcontrib>TAKEUCHI, Yukari</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOIZUMI, Ryoko</au><au>KIYOKAWA, Yasushi</au><au>MIKAMI, Kaori</au><au>ISHII, Akiko</au><au>TANAKA, Kazuyuki D.</au><au>TANIKAWA, Tsutomu</au><au>TAKEUCHI, Yukari</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural differences in the brain between wild and laboratory rats (Rattus norvegicus): Potential contribution to wariness</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. Vet. Med. Sci.</addtitle><date>2018</date><risdate>2018</risdate><volume>80</volume><issue>7</issue><spage>1054</spage><epage>1060</epage><pages>1054-1060</pages><issn>0916-7250</issn><eissn>1347-7439</eissn><abstract>Wild animals typically exhibit defensive behaviors in response to a wider range and/or a weaker intensity of stimuli compared with domestic animals. However, little is known about the neural mechanisms underlying “wariness” in wild animals. Wild rats are one of the most accessible wild animals for experimental research. Laboratory rats are a domesticated form of wild rat, belonging to the same species, and are therefore considered suitable control animals for wild rats. Based on these factors, we analyzed structural differences in the brain between wild and laboratory rats to elucidate the neural mechanisms underlying wariness. We examined wild rats trapped in Tokyo, and weight-matched laboratory rats. We then prepared brain sections and compared the basolateral complex of the amygdala (BLA), the bed nucleus of the stria terminalis (BNST), the main olfactory bulb and the accessory olfactory bulb. The results revealed that wild rats exhibited larger BLA, BNST and caudal part of the accessory olfactory bulb compared with laboratory rats. These results suggest that the BLA, BNST, and vomeronasal system potentially contribute to wariness in wild rats.</abstract><cop>Japan</cop><pub>JAPANESE SOCIETY OF VETERINARY SCIENCE</pub><pmid>29760315</pmid><doi>10.1292/jvms.18-0052</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; PubMed Central |
| subjects | Accessory olfactory bulb Amygdala Animals Animals, Wild basolateral complex of the amygdala bed nucleus of the stria terminalis Brain Brain - physiology Brain - ultrastructure Defensive behavior Domestic animals Ethology Experimental research Female Laboratories main olfactory bulb Male Olfactory Bulb Rats Rodents Stria terminalis vomeronasal receptor Vomeronasal system |
| title | Structural differences in the brain between wild and laboratory rats (Rattus norvegicus): Potential contribution to wariness |
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