The cellular metabolic landscape in the tumor milieu regulates the activity of myeloid infiltrates
Malignant cells upregulate distinct energy metabolism programs that support their proliferation, migration, and adaptation to the stressful tumor microenvironment (TME). Additionally, this exaggerated metabolic activity allows cancer cells to hijack essential nutrients and outcompete neighboring inf...
Gespeichert in:
| Veröffentlicht in: | Cellular & molecular immunology 2018-05, Vol.15 (5), p.421-427 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 427 |
|---|---|
| container_issue | 5 |
| container_start_page | 421 |
| container_title | Cellular & molecular immunology |
| container_volume | 15 |
| creator | Mohamed, Eslam Al-Khami, Amir A. Rodriguez, Paulo C. |
| description | Malignant cells upregulate distinct energy metabolism programs that support their proliferation, migration, and adaptation to the stressful tumor microenvironment (TME). Additionally, this exaggerated metabolic activity allows cancer cells to hijack essential nutrients and outcompete neighboring infiltrating immune cells, thereby impairing antitumor immunity. During recent years, there has been great interest in the field to understand the tumor-induced energy metabolism signals that regulate the function of immune cells in individuals with cancer. Accordingly, it is now well accepted that uncovering the mechanisms that instruct the metabolic behavior of cancer cells and tumor-associated immune cells is an indispensable strategy for the development of new approaches to overcome immune suppression in tumors. Thus, in this minireview, we briefly discuss the interaction between particular metabolic signaling pathways and immunosuppressive activity in different subsets of myeloid cells within the TME. Additionally, we illustrate potential central mechanisms controlling the metabolic reprogramming of myeloid cells in response to tumor-derived factors. |
| doi_str_mv | 10.1038/s41423-018-0001-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6068094</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2018019867</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-606411b34477b8072ef681a8ff63f295b4d9b287501f7fa10818e6810cadd3e63</originalsourceid><addsrcrecordid>eNp1kU9r3DAQxUVJabZpP0AvxZBLL25HstbSXgIh9B8EeknPQrZHGwXZ2khyYL99xt00TQI9CTS_efNmHmMfOHzm0OgvWXIpmhq4rgGA1-oVWwmQogYh2iO24q0StWo1P2Zvc74BWGup5Bt2LDZr-uV6xbqra6x6DGEONlUjFtvF4Psq2GnIvd1h5aeqEFPmMRLgg8e5SrglvmD-U7J98Xe-7KvoqnGPIfqBupwPJS3MO_ba2ZDx_cN7wn5_-3p18aO-_PX958X5Zd1LBaVuoZWcd42USnUalEBHHq12rm0cGe7ksOmEVmvgTjnLQXONREBvh6HBtjlhZwfd3dyNOPQ40fxgdsmPNu1NtN48r0z-2mzjnaHJGjaSBD49CKR4O2MuZvR5uY2dMM7ZCDo08I1uFaGnL9CbOKeJ1iOKzGsJayCKH6g-xZwTukczHMySoDkkaEjYLAmaRfnj0y0eO_5GRoA4AJlK0xbTv9H_V70HAx-nWw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2080784050</pqid></control><display><type>article</type><title>The cellular metabolic landscape in the tumor milieu regulates the activity of myeloid infiltrates</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Mohamed, Eslam ; Al-Khami, Amir A. ; Rodriguez, Paulo C.</creator><creatorcontrib>Mohamed, Eslam ; Al-Khami, Amir A. ; Rodriguez, Paulo C.</creatorcontrib><description>Malignant cells upregulate distinct energy metabolism programs that support their proliferation, migration, and adaptation to the stressful tumor microenvironment (TME). Additionally, this exaggerated metabolic activity allows cancer cells to hijack essential nutrients and outcompete neighboring infiltrating immune cells, thereby impairing antitumor immunity. During recent years, there has been great interest in the field to understand the tumor-induced energy metabolism signals that regulate the function of immune cells in individuals with cancer. Accordingly, it is now well accepted that uncovering the mechanisms that instruct the metabolic behavior of cancer cells and tumor-associated immune cells is an indispensable strategy for the development of new approaches to overcome immune suppression in tumors. Thus, in this minireview, we briefly discuss the interaction between particular metabolic signaling pathways and immunosuppressive activity in different subsets of myeloid cells within the TME. Additionally, we illustrate potential central mechanisms controlling the metabolic reprogramming of myeloid cells in response to tumor-derived factors.</description><identifier>ISSN: 1672-7681</identifier><identifier>EISSN: 2042-0226</identifier><identifier>DOI: 10.1038/s41423-018-0001-7</identifier><identifier>PMID: 29568118</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Antibodies ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; Cell proliferation ; Energy metabolism ; Immunology ; Immunosuppressive agents ; Medical Microbiology ; Metabolism ; Microbiology ; Mini Review ; Myeloid cells ; Nutrients ; Tumors ; Vaccine</subject><ispartof>Cellular & molecular immunology, 2018-05, Vol.15 (5), p.421-427</ispartof><rights>CSI and USTC 2018</rights><rights>Copyright Nature Publishing Group May 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-606411b34477b8072ef681a8ff63f295b4d9b287501f7fa10818e6810cadd3e63</citedby><cites>FETCH-LOGICAL-c470t-606411b34477b8072ef681a8ff63f295b4d9b287501f7fa10818e6810cadd3e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068094/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068094/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29568118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mohamed, Eslam</creatorcontrib><creatorcontrib>Al-Khami, Amir A.</creatorcontrib><creatorcontrib>Rodriguez, Paulo C.</creatorcontrib><title>The cellular metabolic landscape in the tumor milieu regulates the activity of myeloid infiltrates</title><title>Cellular & molecular immunology</title><addtitle>Cell Mol Immunol</addtitle><addtitle>Cell Mol Immunol</addtitle><description>Malignant cells upregulate distinct energy metabolism programs that support their proliferation, migration, and adaptation to the stressful tumor microenvironment (TME). Additionally, this exaggerated metabolic activity allows cancer cells to hijack essential nutrients and outcompete neighboring infiltrating immune cells, thereby impairing antitumor immunity. During recent years, there has been great interest in the field to understand the tumor-induced energy metabolism signals that regulate the function of immune cells in individuals with cancer. Accordingly, it is now well accepted that uncovering the mechanisms that instruct the metabolic behavior of cancer cells and tumor-associated immune cells is an indispensable strategy for the development of new approaches to overcome immune suppression in tumors. Thus, in this minireview, we briefly discuss the interaction between particular metabolic signaling pathways and immunosuppressive activity in different subsets of myeloid cells within the TME. Additionally, we illustrate potential central mechanisms controlling the metabolic reprogramming of myeloid cells in response to tumor-derived factors.</description><subject>Antibodies</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Cell proliferation</subject><subject>Energy metabolism</subject><subject>Immunology</subject><subject>Immunosuppressive agents</subject><subject>Medical Microbiology</subject><subject>Metabolism</subject><subject>Microbiology</subject><subject>Mini Review</subject><subject>Myeloid cells</subject><subject>Nutrients</subject><subject>Tumors</subject><subject>Vaccine</subject><issn>1672-7681</issn><issn>2042-0226</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kU9r3DAQxUVJabZpP0AvxZBLL25HstbSXgIh9B8EeknPQrZHGwXZ2khyYL99xt00TQI9CTS_efNmHmMfOHzm0OgvWXIpmhq4rgGA1-oVWwmQogYh2iO24q0StWo1P2Zvc74BWGup5Bt2LDZr-uV6xbqra6x6DGEONlUjFtvF4Psq2GnIvd1h5aeqEFPmMRLgg8e5SrglvmD-U7J98Xe-7KvoqnGPIfqBupwPJS3MO_ba2ZDx_cN7wn5_-3p18aO-_PX958X5Zd1LBaVuoZWcd42USnUalEBHHq12rm0cGe7ksOmEVmvgTjnLQXONREBvh6HBtjlhZwfd3dyNOPQ40fxgdsmPNu1NtN48r0z-2mzjnaHJGjaSBD49CKR4O2MuZvR5uY2dMM7ZCDo08I1uFaGnL9CbOKeJ1iOKzGsJayCKH6g-xZwTukczHMySoDkkaEjYLAmaRfnj0y0eO_5GRoA4AJlK0xbTv9H_V70HAx-nWw</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Mohamed, Eslam</creator><creator>Al-Khami, Amir A.</creator><creator>Rodriguez, Paulo C.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180501</creationdate><title>The cellular metabolic landscape in the tumor milieu regulates the activity of myeloid infiltrates</title><author>Mohamed, Eslam ; Al-Khami, Amir A. ; Rodriguez, Paulo C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-606411b34477b8072ef681a8ff63f295b4d9b287501f7fa10818e6810cadd3e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Antibodies</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer</topic><topic>Cell proliferation</topic><topic>Energy metabolism</topic><topic>Immunology</topic><topic>Immunosuppressive agents</topic><topic>Medical Microbiology</topic><topic>Metabolism</topic><topic>Microbiology</topic><topic>Mini Review</topic><topic>Myeloid cells</topic><topic>Nutrients</topic><topic>Tumors</topic><topic>Vaccine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mohamed, Eslam</creatorcontrib><creatorcontrib>Al-Khami, Amir A.</creatorcontrib><creatorcontrib>Rodriguez, Paulo C.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular & molecular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mohamed, Eslam</au><au>Al-Khami, Amir A.</au><au>Rodriguez, Paulo C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The cellular metabolic landscape in the tumor milieu regulates the activity of myeloid infiltrates</atitle><jtitle>Cellular & molecular immunology</jtitle><stitle>Cell Mol Immunol</stitle><addtitle>Cell Mol Immunol</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>15</volume><issue>5</issue><spage>421</spage><epage>427</epage><pages>421-427</pages><issn>1672-7681</issn><eissn>2042-0226</eissn><abstract>Malignant cells upregulate distinct energy metabolism programs that support their proliferation, migration, and adaptation to the stressful tumor microenvironment (TME). Additionally, this exaggerated metabolic activity allows cancer cells to hijack essential nutrients and outcompete neighboring infiltrating immune cells, thereby impairing antitumor immunity. During recent years, there has been great interest in the field to understand the tumor-induced energy metabolism signals that regulate the function of immune cells in individuals with cancer. Accordingly, it is now well accepted that uncovering the mechanisms that instruct the metabolic behavior of cancer cells and tumor-associated immune cells is an indispensable strategy for the development of new approaches to overcome immune suppression in tumors. Thus, in this minireview, we briefly discuss the interaction between particular metabolic signaling pathways and immunosuppressive activity in different subsets of myeloid cells within the TME. Additionally, we illustrate potential central mechanisms controlling the metabolic reprogramming of myeloid cells in response to tumor-derived factors.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29568118</pmid><doi>10.1038/s41423-018-0001-7</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1672-7681 |
| ispartof | Cellular & molecular immunology, 2018-05, Vol.15 (5), p.421-427 |
| issn | 1672-7681 2042-0226 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6068094 |
| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Antibodies Biomedical and Life Sciences Biomedicine Cancer Cell proliferation Energy metabolism Immunology Immunosuppressive agents Medical Microbiology Metabolism Microbiology Mini Review Myeloid cells Nutrients Tumors Vaccine |
| title | The cellular metabolic landscape in the tumor milieu regulates the activity of myeloid infiltrates |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T21%3A00%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20cellular%20metabolic%20landscape%20in%20the%20tumor%20milieu%20regulates%20the%20activity%20of%20myeloid%20infiltrates&rft.jtitle=Cellular%20&%20molecular%20immunology&rft.au=Mohamed,%20Eslam&rft.date=2018-05-01&rft.volume=15&rft.issue=5&rft.spage=421&rft.epage=427&rft.pages=421-427&rft.issn=1672-7681&rft.eissn=2042-0226&rft_id=info:doi/10.1038/s41423-018-0001-7&rft_dat=%3Cproquest_pubme%3E2018019867%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2080784050&rft_id=info:pmid/29568118&rfr_iscdi=true |