Association of resilience with health-related quality of life and depression in multiple myeloma and its precursors: results of a German cross-sectional study
ObjectivesTo investigate the relation between resilience, health-related quality of life (HRQOL) and depression in multiple myeloma (MM) and its premalignant stages. MM is one of the most frequent haematological disorders. It is regularly preceded by asymptomatic stages of the disease namely monoclo...
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| Veröffentlicht in: | BMJ open 2018-07, Vol.8 (7), p.e021376-e021376 |
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| creator | Maatouk, Imad He, Susanne Becker, Natalia Hummel, Manuela Hemmer, Stefan Hillengass, Michaela Goldschmidt, Hartmut Hartmann, Mechthild Schellberg, Dieter Herzog, Wolfgang Hillengass, Jens |
| description | ObjectivesTo investigate the relation between resilience, health-related quality of life (HRQOL) and depression in multiple myeloma (MM) and its premalignant stages. MM is one of the most frequent haematological disorders. It is regularly preceded by asymptomatic stages of the disease namely monoclonal gammopathy of undetermined significance (MGUS) and smouldering multiple myeloma (SMM). Survivors have to cope with mental and physical impairment in terms of HRQOL and depression. The concept of resilience refers to a person’s ability to adapt to adversity.DesignCross-sectional study.SettingMM outpatient department at a University Hospital in Germany (tertiary care).Participants292 consecutive patients from our MM outpatient department.Outcome measuresHRQOL, depression and psychological resilience were assessed with validated questionnaires.ResultsRegression analyses were performed to determine associations between resilience, HRQOL and depression. 98 patients (33.6%) had a new diagnosis of active MM, 106 patients (36.3%) were already treated for MM and 88 patients had the diagnosis of a precursor (MGUS or SMM; 30.1%) of MM. Multivariate linear regression analyses revealed a strong positive impact of resilience on physical (b 7.20; 95% CI 4.43 to 9.98; p |
| doi_str_mv | 10.1136/bmjopen-2017-021376 |
| format | Article |
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MM is one of the most frequent haematological disorders. It is regularly preceded by asymptomatic stages of the disease namely monoclonal gammopathy of undetermined significance (MGUS) and smouldering multiple myeloma (SMM). Survivors have to cope with mental and physical impairment in terms of HRQOL and depression. The concept of resilience refers to a person’s ability to adapt to adversity.DesignCross-sectional study.SettingMM outpatient department at a University Hospital in Germany (tertiary care).Participants292 consecutive patients from our MM outpatient department.Outcome measuresHRQOL, depression and psychological resilience were assessed with validated questionnaires.ResultsRegression analyses were performed to determine associations between resilience, HRQOL and depression. 98 patients (33.6%) had a new diagnosis of active MM, 106 patients (36.3%) were already treated for MM and 88 patients had the diagnosis of a precursor (MGUS or SMM; 30.1%) of MM. Multivariate linear regression analyses revealed a strong positive impact of resilience on physical (b 7.20; 95% CI 4.43 to 9.98; p<0.001) and mental (b 12.12; 95% CI 9.36 to 14.87; p<0.001) HRQOL. Ordered logistic regression analysis showed that the odds for higher depression severity were lowered for individuals with a high level of resilience in comparison to the individuals with a low level of resilience (OR 0.11; 95% CI 0.06 to 0.19; p<0.001).ConclusionsResilience may be a protective factor in the disease trajectory of MM and its precursors. As a next step, future research should focus on longitudinal assessments at various time points to elucidate the role of resilience in one of the most frequent haematological malignancies.</description><identifier>ISSN: 2044-6055</identifier><identifier>EISSN: 2044-6055</identifier><identifier>DOI: 10.1136/bmjopen-2017-021376</identifier><identifier>PMID: 30061438</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Blood cancer ; Breast cancer ; Cancer therapies ; Clinical trials ; Cross-sectional studies ; Haematology (Incl Blood Transfusion) ; Medical prognosis ; Mental depression ; Mental health ; Multiple myeloma ; Patients ; Quality of life ; Questionnaires ; Stem cells ; Systematic review</subject><ispartof>BMJ open, 2018-07, Vol.8 (7), p.e021376-e021376</ispartof><rights>Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2018 Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b472t-362d943a256e90486d80d410977a89f9b3d106ead451601eb10c14c5218ca9053</citedby><cites>FETCH-LOGICAL-b472t-362d943a256e90486d80d410977a89f9b3d106ead451601eb10c14c5218ca9053</cites><orcidid>0000-0002-8030-1182</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://bmjopen.bmj.com/content/8/7/e021376.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://bmjopen.bmj.com/content/8/7/e021376.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27526,27527,27901,27902,53766,53768,77344,77375</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30061438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maatouk, Imad</creatorcontrib><creatorcontrib>He, Susanne</creatorcontrib><creatorcontrib>Becker, Natalia</creatorcontrib><creatorcontrib>Hummel, Manuela</creatorcontrib><creatorcontrib>Hemmer, Stefan</creatorcontrib><creatorcontrib>Hillengass, Michaela</creatorcontrib><creatorcontrib>Goldschmidt, Hartmut</creatorcontrib><creatorcontrib>Hartmann, Mechthild</creatorcontrib><creatorcontrib>Schellberg, Dieter</creatorcontrib><creatorcontrib>Herzog, Wolfgang</creatorcontrib><creatorcontrib>Hillengass, Jens</creatorcontrib><title>Association of resilience with health-related quality of life and depression in multiple myeloma and its precursors: results of a German cross-sectional study</title><title>BMJ open</title><addtitle>BMJ Open</addtitle><description>ObjectivesTo investigate the relation between resilience, health-related quality of life (HRQOL) and depression in multiple myeloma (MM) and its premalignant stages. MM is one of the most frequent haematological disorders. It is regularly preceded by asymptomatic stages of the disease namely monoclonal gammopathy of undetermined significance (MGUS) and smouldering multiple myeloma (SMM). Survivors have to cope with mental and physical impairment in terms of HRQOL and depression. The concept of resilience refers to a person’s ability to adapt to adversity.DesignCross-sectional study.SettingMM outpatient department at a University Hospital in Germany (tertiary care).Participants292 consecutive patients from our MM outpatient department.Outcome measuresHRQOL, depression and psychological resilience were assessed with validated questionnaires.ResultsRegression analyses were performed to determine associations between resilience, HRQOL and depression. 98 patients (33.6%) had a new diagnosis of active MM, 106 patients (36.3%) were already treated for MM and 88 patients had the diagnosis of a precursor (MGUS or SMM; 30.1%) of MM. Multivariate linear regression analyses revealed a strong positive impact of resilience on physical (b 7.20; 95% CI 4.43 to 9.98; p<0.001) and mental (b 12.12; 95% CI 9.36 to 14.87; p<0.001) HRQOL. Ordered logistic regression analysis showed that the odds for higher depression severity were lowered for individuals with a high level of resilience in comparison to the individuals with a low level of resilience (OR 0.11; 95% CI 0.06 to 0.19; p<0.001).ConclusionsResilience may be a protective factor in the disease trajectory of MM and its precursors. As a next step, future research should focus on longitudinal assessments at various time points to elucidate the role of resilience in one of the most frequent haematological malignancies.</description><subject>Blood cancer</subject><subject>Breast cancer</subject><subject>Cancer therapies</subject><subject>Clinical trials</subject><subject>Cross-sectional studies</subject><subject>Haematology (Incl Blood Transfusion)</subject><subject>Medical prognosis</subject><subject>Mental depression</subject><subject>Mental health</subject><subject>Multiple myeloma</subject><subject>Patients</subject><subject>Quality of life</subject><subject>Questionnaires</subject><subject>Stem cells</subject><subject>Systematic review</subject><issn>2044-6055</issn><issn>2044-6055</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>BENPR</sourceid><recordid>eNqNksFu1DAQhiMEolXpEyAhS1y4pIxjx4k5IFUVbZEqcYGz5dgT1isn3toOaF-GZ8XpLlXhhC-25O__Z8b-q-o1hQtKmXg_TNuww7lugHY1NJR14ll12gDntYC2ff7kfFKdp7SFsngr27Z5WZ0wAEE560-rX5cpBeN0dmEmYSQRk_MOZ4Pkp8sbskHt86aO6HVGS-4X7V3er6R3IxI9W2JxV1RpNXAzmRaf3c4jmfbow6QfEJcTKZBZYgoxfVirFCytNprcYJz0TEwMKdUJzdqK9iTlxe5fVS9G7ROeH_ez6tv1p69Xt_Xdl5vPV5d39cC7JtdMNFZypptWoATeC9uD5RRk1-lejnJgloJAbXlLBVAcKBjKTdvQ3mgJLTurPh58d8swoTU456i92kU36bhXQTv1983sNup7-KEEiI5DVwzeHQ1iuF8wZTW5ZNB7PWNYkmqgh551Uq613v6DbsMSy8grJSXvei5oodiBeniXiONjMxTUGgF1jIBaI6AOESiqN0_neNT8-fACXByAov4vx9_Cn8At</recordid><startdate>20180730</startdate><enddate>20180730</enddate><creator>Maatouk, Imad</creator><creator>He, Susanne</creator><creator>Becker, Natalia</creator><creator>Hummel, Manuela</creator><creator>Hemmer, Stefan</creator><creator>Hillengass, Michaela</creator><creator>Goldschmidt, Hartmut</creator><creator>Hartmann, Mechthild</creator><creator>Schellberg, Dieter</creator><creator>Herzog, Wolfgang</creator><creator>Hillengass, Jens</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>9YT</scope><scope>ACMMV</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8030-1182</orcidid></search><sort><creationdate>20180730</creationdate><title>Association of resilience with health-related quality of life and depression in multiple myeloma and its precursors: results of a German cross-sectional study</title><author>Maatouk, Imad ; He, Susanne ; Becker, Natalia ; Hummel, Manuela ; Hemmer, Stefan ; Hillengass, Michaela ; Goldschmidt, Hartmut ; Hartmann, Mechthild ; Schellberg, Dieter ; Herzog, Wolfgang ; Hillengass, Jens</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b472t-362d943a256e90486d80d410977a89f9b3d106ead451601eb10c14c5218ca9053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Blood cancer</topic><topic>Breast cancer</topic><topic>Cancer therapies</topic><topic>Clinical trials</topic><topic>Cross-sectional studies</topic><topic>Haematology (Incl Blood Transfusion)</topic><topic>Medical prognosis</topic><topic>Mental depression</topic><topic>Mental health</topic><topic>Multiple myeloma</topic><topic>Patients</topic><topic>Quality of life</topic><topic>Questionnaires</topic><topic>Stem cells</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maatouk, Imad</creatorcontrib><creatorcontrib>He, Susanne</creatorcontrib><creatorcontrib>Becker, Natalia</creatorcontrib><creatorcontrib>Hummel, Manuela</creatorcontrib><creatorcontrib>Hemmer, Stefan</creatorcontrib><creatorcontrib>Hillengass, Michaela</creatorcontrib><creatorcontrib>Goldschmidt, Hartmut</creatorcontrib><creatorcontrib>Hartmann, Mechthild</creatorcontrib><creatorcontrib>Schellberg, Dieter</creatorcontrib><creatorcontrib>Herzog, Wolfgang</creatorcontrib><creatorcontrib>Hillengass, Jens</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maatouk, Imad</au><au>He, Susanne</au><au>Becker, Natalia</au><au>Hummel, Manuela</au><au>Hemmer, Stefan</au><au>Hillengass, Michaela</au><au>Goldschmidt, Hartmut</au><au>Hartmann, Mechthild</au><au>Schellberg, Dieter</au><au>Herzog, Wolfgang</au><au>Hillengass, Jens</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of resilience with health-related quality of life and depression in multiple myeloma and its precursors: results of a German cross-sectional study</atitle><jtitle>BMJ open</jtitle><addtitle>BMJ Open</addtitle><date>2018-07-30</date><risdate>2018</risdate><volume>8</volume><issue>7</issue><spage>e021376</spage><epage>e021376</epage><pages>e021376-e021376</pages><issn>2044-6055</issn><eissn>2044-6055</eissn><abstract>ObjectivesTo investigate the relation between resilience, health-related quality of life (HRQOL) and depression in multiple myeloma (MM) and its premalignant stages. MM is one of the most frequent haematological disorders. It is regularly preceded by asymptomatic stages of the disease namely monoclonal gammopathy of undetermined significance (MGUS) and smouldering multiple myeloma (SMM). Survivors have to cope with mental and physical impairment in terms of HRQOL and depression. The concept of resilience refers to a person’s ability to adapt to adversity.DesignCross-sectional study.SettingMM outpatient department at a University Hospital in Germany (tertiary care).Participants292 consecutive patients from our MM outpatient department.Outcome measuresHRQOL, depression and psychological resilience were assessed with validated questionnaires.ResultsRegression analyses were performed to determine associations between resilience, HRQOL and depression. 98 patients (33.6%) had a new diagnosis of active MM, 106 patients (36.3%) were already treated for MM and 88 patients had the diagnosis of a precursor (MGUS or SMM; 30.1%) of MM. Multivariate linear regression analyses revealed a strong positive impact of resilience on physical (b 7.20; 95% CI 4.43 to 9.98; p<0.001) and mental (b 12.12; 95% CI 9.36 to 14.87; p<0.001) HRQOL. Ordered logistic regression analysis showed that the odds for higher depression severity were lowered for individuals with a high level of resilience in comparison to the individuals with a low level of resilience (OR 0.11; 95% CI 0.06 to 0.19; p<0.001).ConclusionsResilience may be a protective factor in the disease trajectory of MM and its precursors. As a next step, future research should focus on longitudinal assessments at various time points to elucidate the role of resilience in one of the most frequent haematological malignancies.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>30061438</pmid><doi>10.1136/bmjopen-2017-021376</doi><orcidid>https://orcid.org/0000-0002-8030-1182</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Blood cancer Breast cancer Cancer therapies Clinical trials Cross-sectional studies Haematology (Incl Blood Transfusion) Medical prognosis Mental depression Mental health Multiple myeloma Patients Quality of life Questionnaires Stem cells Systematic review |
| title | Association of resilience with health-related quality of life and depression in multiple myeloma and its precursors: results of a German cross-sectional study |
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