Gene drives to fight malaria: current state and future directions
Self-propagating gene drive technologies have a number of desirable characteristics that warrant their development for the control of insect pest and vector populations, such as the malaria-transmitting mosquitoes. Theoretically easy to deploy and self-sustaining, these tools may be used to generate...
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| Veröffentlicht in: | Pathogens and global health 2017-12, Vol.111 (8), p.412-423 |
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| container_title | Pathogens and global health |
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| creator | Hammond, Andrew M Galizi, Roberto |
| description | Self-propagating gene drive technologies have a number of desirable characteristics that warrant their development for the control of insect pest and vector populations, such as the malaria-transmitting mosquitoes. Theoretically easy to deploy and self-sustaining, these tools may be used to generate cost-effective interventions that benefit society without obvious bias related to wealth, age or education. Their species-specific design offers the potential to reduce environmental risks and aim to be compatible and complementary with other control strategies, potentially expediting the elimination and eradication of malaria. A number of strategies have been proposed for gene-drive based control of the malaria mosquito and recent demonstrations have shown proof-of-principle in the laboratory. Though several technical, ethical and regulatory challenges remain, none appear insurmountable if research continues in a step-wise and open manner. |
| doi_str_mv | 10.1080/20477724.2018.1438880 |
| format | Article |
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| ispartof | Pathogens and global health, 2017-12, Vol.111 (8), p.412-423 |
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| language | eng |
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| source | MEDLINE; PubMed Central |
| subjects | Animals Disease Transmission, Infectious - prevention & control Gene Drive Technology - methods Gene Drive Technology - trends Humans Malaria - prevention & control Mosquito Control - methods Mosquito Control - trends Review |
| title | Gene drives to fight malaria: current state and future directions |
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