Chaperone Activity and Dimerization Properties of Hsp90α and Hsp90β in Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery

Several hundred proteins cycle into heterocomplexes with a dimer of the chaperone heat shock protein 90 (Hsp90), regulating their activity and turnover. There are two isoforms of Hsp90, Hsp90α and Hsp90β, and their relative chaperone activities and composition in these client protein•Hsp90 heterocom...

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Veröffentlicht in:Molecular pharmacology 2018-09, Vol.94 (3), p.984-991
Hauptverfasser: Morishima, Yoshihiro, Mehta, Ranjit K., Yoshimura, Miyako, Lau, Miranda, Southworth, Daniel R., Lawrence, Theodore S., Pratt, William B., Nyati, Mukesh K., Osawa, Yoichi
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Sprache:eng
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