Metreleptin-mediated improvements in insulin sensitivity are independent of food intake in humans with lipodystrophy

Recombinant leptin (metreleptin) ameliorates hyperphagia and metabolic abnormalities in leptin-deficient humans with lipodystrophy. We aimed to determine whether metreleptin improves glucose and lipid metabolism in humans when food intake is held constant. Patients with lipodystrophy were hospitaliz...

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Veröffentlicht in:	The Journal of clinical investigation 2018-08, Vol.128 (8), p.3504-3516
Hauptverfasser:	Brown, Rebecca J, Valencia, Areli, Startzell, Megan, Cochran, Elaine, Walter, Peter J, Garraffo, H Martin, Cai, Hongyi, Gharib, Ahmed M, Ouwerkerk, Ronald, Courville, Amber B, Bernstein, Shanna, Brychta, Robert J, Chen, Kong Y, Walter, Mary, Auh, Sungyoung, Gorden, Phillip
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical research Care and treatment Clinical Medicine Diagnosis Diet Fasting Food intake Glucose Glucose metabolism Glycerol Health aspects Hyperphagia Insulin Insulin resistance Kinases Leptin Lipid metabolism Lipodystrophy Lipolysis Liver Magnetic resonance spectroscopy Metreleptin Palmitic acid Patient outcomes Patients Rodents Tracers Triglycerides
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