Perspective of Future Potent Therapies for Fuchs Endothelial Corneal Dystrophy

Perspective of Future Potent Therapies for Fuchs Endothelial Corneal Dystrophy

Fuchs Endothelial Corneal Dystrophy (FECD) is a progressive disease that affects the corneal endothelium in both eyes. Recent studies have identified a novel genetic basis for FECD, and basic research findings have provided evidence for its underlying pathophysiology. Since its first description by...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The open ophthalmology journal 2018-01, Vol.12 (1), p.154-163
Hauptverfasser: Okumura, Naoki, Hayashi, Ryousuke, Koizumi, Noriko
Format: Artikel
Sprache:eng
Schlagworte:
Ophthalmology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 163
container_issue 1
container_start_page 154
container_title The open ophthalmology journal
container_volume 12
creator Okumura, Naoki
Hayashi, Ryousuke
Koizumi, Noriko
description Fuchs Endothelial Corneal Dystrophy (FECD) is a progressive disease that affects the corneal endothelium in both eyes. Recent studies have identified a novel genetic basis for FECD, and basic research findings have provided evidence for its underlying pathophysiology. Since its first description by Ernst Fuchs in 1910, the only therapeutic choice has been corneal transplantation using donor corneas. However, accumulating evidence suggests that a change in this "rule" may be imminent. This article reviews the current knowledge of the genetics and pathophysiology of FECD, and it introduces some potent therapeutic modalities that show promise as new treatments for this disorder.
doi_str_mv 10.2174/1874364101812010154
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6062905</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2090298204</sourcerecordid><originalsourceid>FETCH-LOGICAL-c471t-f5edc074bedbd37cc2d45a21ef134f4eebf6ab2329d078391402c968d5d7a1193</originalsourceid><addsrcrecordid>eNptUU1Lw0AQXUSxtfoLBMnRS3S_8rEXQWqrQtEe6nnZbGZNJM3G3aTQf29Ca6ng6Q3z5r0Z5iF0TfAdJQm_J2nCWcwJJimhuIeIn6Dx0A2H9ulRPUIX3n9hHFMhxDkaMUwoYykeo7clON-AbssNBNYE867tHARL20LdBqsCnGpK8IGxrud04YNZndu2gKpUVTC1roYen7a-dbYptpfozKjKw9UeJ-hjPltNX8LF-_Pr9HERap6QNjQR5BonPIM8y1miNc15pCgBQxg3HCAzscoooyLHScoE4ZhqEad5lCeKEMEm6GHn23TZuvfqj3Wqko0r18ptpVWl_MvUZSE_7UbGww9w1Bvc7g2c_e7At3Jdeg1VpWqwnZcUC0xFSjHvR9luVDvrvQNzWEOwHJKQ_yTRq26OLzxofl_PfgDWSIU7</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2090298204</pqid></control><display><type>article</type><title>Perspective of Future Potent Therapies for Fuchs Endothelial Corneal Dystrophy</title><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Okumura, Naoki ; Hayashi, Ryousuke ; Koizumi, Noriko</creator><creatorcontrib>Okumura, Naoki ; Hayashi, Ryousuke ; Koizumi, Noriko</creatorcontrib><description>Fuchs Endothelial Corneal Dystrophy (FECD) is a progressive disease that affects the corneal endothelium in both eyes. Recent studies have identified a novel genetic basis for FECD, and basic research findings have provided evidence for its underlying pathophysiology. Since its first description by Ernst Fuchs in 1910, the only therapeutic choice has been corneal transplantation using donor corneas. However, accumulating evidence suggests that a change in this "rule" may be imminent. This article reviews the current knowledge of the genetics and pathophysiology of FECD, and it introduces some potent therapeutic modalities that show promise as new treatments for this disorder.</description><identifier>ISSN: 1874-3641</identifier><identifier>EISSN: 1874-3641</identifier><identifier>DOI: 10.2174/1874364101812010154</identifier><identifier>PMID: 30123380</identifier><language>eng</language><publisher>United Arab Emirates: Bentham Open</publisher><subject>Ophthalmology</subject><ispartof>The open ophthalmology journal, 2018-01, Vol.12 (1), p.154-163</ispartof><rights>2018 Okumura . 2018 Okumura.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-f5edc074bedbd37cc2d45a21ef134f4eebf6ab2329d078391402c968d5d7a1193</citedby><cites>FETCH-LOGICAL-c471t-f5edc074bedbd37cc2d45a21ef134f4eebf6ab2329d078391402c968d5d7a1193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062905/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062905/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30123380$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okumura, Naoki</creatorcontrib><creatorcontrib>Hayashi, Ryousuke</creatorcontrib><creatorcontrib>Koizumi, Noriko</creatorcontrib><title>Perspective of Future Potent Therapies for Fuchs Endothelial Corneal Dystrophy</title><title>The open ophthalmology journal</title><addtitle>Open Ophthalmol J</addtitle><description>Fuchs Endothelial Corneal Dystrophy (FECD) is a progressive disease that affects the corneal endothelium in both eyes. Recent studies have identified a novel genetic basis for FECD, and basic research findings have provided evidence for its underlying pathophysiology. Since its first description by Ernst Fuchs in 1910, the only therapeutic choice has been corneal transplantation using donor corneas. However, accumulating evidence suggests that a change in this "rule" may be imminent. This article reviews the current knowledge of the genetics and pathophysiology of FECD, and it introduces some potent therapeutic modalities that show promise as new treatments for this disorder.</description><subject>Ophthalmology</subject><issn>1874-3641</issn><issn>1874-3641</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNptUU1Lw0AQXUSxtfoLBMnRS3S_8rEXQWqrQtEe6nnZbGZNJM3G3aTQf29Ca6ng6Q3z5r0Z5iF0TfAdJQm_J2nCWcwJJimhuIeIn6Dx0A2H9ulRPUIX3n9hHFMhxDkaMUwoYykeo7clON-AbssNBNYE867tHARL20LdBqsCnGpK8IGxrud04YNZndu2gKpUVTC1roYen7a-dbYptpfozKjKw9UeJ-hjPltNX8LF-_Pr9HERap6QNjQR5BonPIM8y1miNc15pCgBQxg3HCAzscoooyLHScoE4ZhqEad5lCeKEMEm6GHn23TZuvfqj3Wqko0r18ptpVWl_MvUZSE_7UbGww9w1Bvc7g2c_e7At3Jdeg1VpWqwnZcUC0xFSjHvR9luVDvrvQNzWEOwHJKQ_yTRq26OLzxofl_PfgDWSIU7</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Okumura, Naoki</creator><creator>Hayashi, Ryousuke</creator><creator>Koizumi, Noriko</creator><general>Bentham Open</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180101</creationdate><title>Perspective of Future Potent Therapies for Fuchs Endothelial Corneal Dystrophy</title><author>Okumura, Naoki ; Hayashi, Ryousuke ; Koizumi, Noriko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-f5edc074bedbd37cc2d45a21ef134f4eebf6ab2329d078391402c968d5d7a1193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Ophthalmology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okumura, Naoki</creatorcontrib><creatorcontrib>Hayashi, Ryousuke</creatorcontrib><creatorcontrib>Koizumi, Noriko</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The open ophthalmology journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okumura, Naoki</au><au>Hayashi, Ryousuke</au><au>Koizumi, Noriko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Perspective of Future Potent Therapies for Fuchs Endothelial Corneal Dystrophy</atitle><jtitle>The open ophthalmology journal</jtitle><addtitle>Open Ophthalmol J</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>12</volume><issue>1</issue><spage>154</spage><epage>163</epage><pages>154-163</pages><issn>1874-3641</issn><eissn>1874-3641</eissn><abstract>Fuchs Endothelial Corneal Dystrophy (FECD) is a progressive disease that affects the corneal endothelium in both eyes. Recent studies have identified a novel genetic basis for FECD, and basic research findings have provided evidence for its underlying pathophysiology. Since its first description by Ernst Fuchs in 1910, the only therapeutic choice has been corneal transplantation using donor corneas. However, accumulating evidence suggests that a change in this "rule" may be imminent. This article reviews the current knowledge of the genetics and pathophysiology of FECD, and it introduces some potent therapeutic modalities that show promise as new treatments for this disorder.</abstract><cop>United Arab Emirates</cop><pub>Bentham Open</pub><pmid>30123380</pmid><doi>10.2174/1874364101812010154</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1874-3641
ispartof The open ophthalmology journal, 2018-01, Vol.12 (1), p.154-163
issn 1874-3641
1874-3641
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6062905
source PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Ophthalmology
title Perspective of Future Potent Therapies for Fuchs Endothelial Corneal Dystrophy
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T06%3A16%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Perspective%20of%20Future%20Potent%20Therapies%20for%20Fuchs%20Endothelial%20Corneal%20Dystrophy&rft.jtitle=The%20open%20ophthalmology%20journal&rft.au=Okumura,%20Naoki&rft.date=2018-01-01&rft.volume=12&rft.issue=1&rft.spage=154&rft.epage=163&rft.pages=154-163&rft.issn=1874-3641&rft.eissn=1874-3641&rft_id=info:doi/10.2174/1874364101812010154&rft_dat=%3Cproquest_pubme%3E2090298204%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2090298204&rft_id=info:pmid/30123380&rfr_iscdi=true