Synthesis and application of poly(ethylene glycol)-co-poly(β-amino ester) copolymers for small cell lung cancer gene therapy

[Display omitted] The design of polymeric nanoparticles for gene therapy requires engineering of polymer structure to overcome multiple barriers, including prolonged colloidal stability during formulation and application. Poly(β-amino ester)s (PBAEs) have been shown effective as polymeric vectors fo...

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Veröffentlicht in:	Acta biomaterialia 2016-09, Vol.41, p.293-301
Hauptverfasser:	Kim, Jayoung, Kang, Yechan, Tzeng, Stephany Y., Green, Jordan J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biodegradability Cancer Cell Death - drug effects Cell Line, Tumor Deoxyribonucleic acid Endocytosis - drug effects Flow Cytometry Formulations Ganciclovir - pharmacology Ganciclovir - therapeutic use Gene therapy Genetic Therapy Green Fluorescent Proteins - metabolism Herpes simplex virus Humans Lung cancer Lung Neoplasms - genetics Lung Neoplasms - therapy Lungs Nanoparticles Particle Size Polyethylene glycol Polyethylene Glycols - chemical synthesis Polyethylene Glycols - chemistry Polymeric nanoparticle Polymers - chemical synthesis Polymers - chemistry Simplexvirus - enzymology Small Cell Lung Carcinoma - genetics Small Cell Lung Carcinoma - therapy Stability Surface modification Thymidine Kinase - metabolism Transfection
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