The effect of moderate weight loss, with or without (1, 3)(1, 6)-β-glucan addition, on subcutaneous adipose tissue inflammatory gene expression in young subjects with uncomplicated obesity
Purpose Obesity is characterized by insulin resistance and low-grade systemic and adipose tissue (AT) inflammation. It remains unclear whether beneficial effects of weight loss are related to AT inflammation. We aimed to assess the effect of weight loss during low-calorie diet on insulin sensitivity...
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| Veröffentlicht in: | Endocrine 2018-08, Vol.61 (2), p.275-284 |
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| creator | Strączkowski, Marek Nikołajuk, Agnieszka Majewski, Radosław Filarski, Remigiusz Stefanowicz, Magdalena Matulewicz, Natalia Karczewska-Kupczewska, Monika |
| description | Purpose
Obesity is characterized by insulin resistance and low-grade systemic and adipose tissue (AT) inflammation. It remains unclear whether beneficial effects of weight loss are related to AT inflammation. We aimed to assess the effect of weight loss during low-calorie diet on insulin sensitivity, AT expression of genes associated with inflammation in young subjects with obesity. Furthermore, we estimated the effects of immunomodulatory (1, 3)(1, 6)-β-glucan (BG) on the above parameters.
Methods
The study group comprised 52 subjects with obesity. Twelve-week dietary intervention was applied, with randomization to receive or not 500 mg BG daily. Euglycemic hyperinsulinemic clamp, subcutaneous AT biopsy were performed before and after the program. Twenty normal-weight subjects, examined at baseline, served as a control group.
Results
At baseline, obese subjects had lower insulin sensitivity, lower AT
ADIPOQ
,
JAK1
, and
JAK2
expression and higher AT expression of
LEP
,
IL6ST
,
STAT3
,
MIF
,
CCL2
,
MMP9
, and
IL18
. Forty obese subjects completed dietary intervention program, which resulted in 11.3% weight loss and 27% increase in insulin sensitivity (both
p
|
| doi_str_mv | 10.1007/s12020-018-1619-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6061191</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2070858459</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-f5a28f26489ca8c337e697bf0242573d8a7e346410dbeb3efb392256bc39b7f3</originalsourceid><addsrcrecordid>eNp1Ustu1DAUjRCIlsIHsEGW2LTSBPxI4mSDhKrykCqxmQU7y3GuMx4l9uBHy_Sz2PcX-CY8pJSHxMbX8j333HN9T1E8J_gVwZi_DoRiiktM2pI0pCtvHhTHpK67_ILxw3xndV1i3H4-Kp6EsMWYUtrwx8UR7TjjVVcdF7frDSDQGlRETqPZDeBlBHQNZtxENLkQVujaxA1y_md0KaJTskLs7HA2Z-X3b-U4JSUtksNgonF2hZxFIfUqRWnBpZAzZucCoGhCSICM1ZOcZxmd36MRbFbwdechhFyck2jvkh0PDNssKyztk1Vu3k1GZXUDcj0EE_dPi0daTgGe3cWTYv3uYn3-obz89P7j-dvLUlUcx1LXkraaNlXbKdkqxjg0He81phWtORtayYFVTUXw0EPPQPeso7RuesW6nmt2UrxZaHepn2FQYKOXk9h5M0u_F04a8XfGmo0Y3ZVocENIRzLB6R2Bd18ShChmExRM0_I_gmLW0Lwo1mXoy3-gW5e8zdNlFMdt3Vb1AUUWlPJ5Qx70vRiCxcEbYvGGyN4QB2-Im1zz4s8p7it-mSED6AIIOWVH8L9b_5_1B_hNyXQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2070858459</pqid></control><display><type>article</type><title>The effect of moderate weight loss, with or without (1, 3)(1, 6)-β-glucan addition, on subcutaneous adipose tissue inflammatory gene expression in young subjects with uncomplicated obesity</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Strączkowski, Marek ; Nikołajuk, Agnieszka ; Majewski, Radosław ; Filarski, Remigiusz ; Stefanowicz, Magdalena ; Matulewicz, Natalia ; Karczewska-Kupczewska, Monika</creator><creatorcontrib>Strączkowski, Marek ; Nikołajuk, Agnieszka ; Majewski, Radosław ; Filarski, Remigiusz ; Stefanowicz, Magdalena ; Matulewicz, Natalia ; Karczewska-Kupczewska, Monika</creatorcontrib><description>Purpose
Obesity is characterized by insulin resistance and low-grade systemic and adipose tissue (AT) inflammation. It remains unclear whether beneficial effects of weight loss are related to AT inflammation. We aimed to assess the effect of weight loss during low-calorie diet on insulin sensitivity, AT expression of genes associated with inflammation in young subjects with obesity. Furthermore, we estimated the effects of immunomodulatory (1, 3)(1, 6)-β-glucan (BG) on the above parameters.
Methods
The study group comprised 52 subjects with obesity. Twelve-week dietary intervention was applied, with randomization to receive or not 500 mg BG daily. Euglycemic hyperinsulinemic clamp, subcutaneous AT biopsy were performed before and after the program. Twenty normal-weight subjects, examined at baseline, served as a control group.
Results
At baseline, obese subjects had lower insulin sensitivity, lower AT
ADIPOQ
,
JAK1
, and
JAK2
expression and higher AT expression of
LEP
,
IL6ST
,
STAT3
,
MIF
,
CCL2
,
MMP9
, and
IL18
. Forty obese subjects completed dietary intervention program, which resulted in 11.3% weight loss and 27% increase in insulin sensitivity (both
p
< 0.0001). AT
IL6R
,
IL6ST
,
JAK1
, and
JAK2
expression increased, whereas
MIF
,
CCL2
,
MMP9
, and
IL18
gene expression did not change in response to weight loss. BG addition had no effect on any of the parameters studied.
Conclusions
Our data indicate that reduction in AT inflammation is not required for an improvement in insulin action during weight loss in subjects with uncomplicated obesity. BG does not have effects during dietary intervention.</description><identifier>ISSN: 1355-008X</identifier><identifier>EISSN: 1559-0100</identifier><identifier>DOI: 10.1007/s12020-018-1619-z</identifier><identifier>PMID: 29737494</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adipose tissue ; Adult ; beta-Glucans - administration & dosage ; beta-Glucans - pharmacology ; Biopsy ; Body weight loss ; Caloric Restriction ; Diabetes ; Endocrinology ; Female ; Gelatinase B ; Gene expression ; Gene Expression - drug effects ; Humanities and Social Sciences ; Humans ; Hypocaloric diet ; Immunomodulation ; Inflammation ; Inflammation - complications ; Inflammation - genetics ; Inflammation - metabolism ; Inflammation - pathology ; Insulin ; Insulin resistance ; Insulin Resistance - genetics ; Interleukin 1 ; Interleukin 18 ; Interleukin 6 ; Interleukin 6 receptors ; Internal Medicine ; Janus kinase ; Janus kinase 2 ; Male ; Medicine ; Medicine & Public Health ; Monocyte chemoattractant protein 1 ; multidisciplinary ; Nutrient deficiency ; Obesity ; Obesity - complications ; Obesity - diet therapy ; Obesity - genetics ; Obesity - pathology ; Original ; Original Article ; Science ; Stat3 protein ; Subcutaneous Fat - drug effects ; Subcutaneous Fat - metabolism ; Subcutaneous Fat - pathology ; Weight control ; Weight Loss - physiology ; Young Adult ; β-Glucan</subject><ispartof>Endocrine, 2018-08, Vol.61 (2), p.275-284</ispartof><rights>The Author(s) 2018</rights><rights>Copyright Springer Science & Business Media 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-f5a28f26489ca8c337e697bf0242573d8a7e346410dbeb3efb392256bc39b7f3</citedby><cites>FETCH-LOGICAL-c470t-f5a28f26489ca8c337e697bf0242573d8a7e346410dbeb3efb392256bc39b7f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12020-018-1619-z$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12020-018-1619-z$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29737494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Strączkowski, Marek</creatorcontrib><creatorcontrib>Nikołajuk, Agnieszka</creatorcontrib><creatorcontrib>Majewski, Radosław</creatorcontrib><creatorcontrib>Filarski, Remigiusz</creatorcontrib><creatorcontrib>Stefanowicz, Magdalena</creatorcontrib><creatorcontrib>Matulewicz, Natalia</creatorcontrib><creatorcontrib>Karczewska-Kupczewska, Monika</creatorcontrib><title>The effect of moderate weight loss, with or without (1, 3)(1, 6)-β-glucan addition, on subcutaneous adipose tissue inflammatory gene expression in young subjects with uncomplicated obesity</title><title>Endocrine</title><addtitle>Endocrine</addtitle><addtitle>Endocrine</addtitle><description>Purpose
Obesity is characterized by insulin resistance and low-grade systemic and adipose tissue (AT) inflammation. It remains unclear whether beneficial effects of weight loss are related to AT inflammation. We aimed to assess the effect of weight loss during low-calorie diet on insulin sensitivity, AT expression of genes associated with inflammation in young subjects with obesity. Furthermore, we estimated the effects of immunomodulatory (1, 3)(1, 6)-β-glucan (BG) on the above parameters.
Methods
The study group comprised 52 subjects with obesity. Twelve-week dietary intervention was applied, with randomization to receive or not 500 mg BG daily. Euglycemic hyperinsulinemic clamp, subcutaneous AT biopsy were performed before and after the program. Twenty normal-weight subjects, examined at baseline, served as a control group.
Results
At baseline, obese subjects had lower insulin sensitivity, lower AT
ADIPOQ
,
JAK1
, and
JAK2
expression and higher AT expression of
LEP
,
IL6ST
,
STAT3
,
MIF
,
CCL2
,
MMP9
, and
IL18
. Forty obese subjects completed dietary intervention program, which resulted in 11.3% weight loss and 27% increase in insulin sensitivity (both
p
< 0.0001). AT
IL6R
,
IL6ST
,
JAK1
, and
JAK2
expression increased, whereas
MIF
,
CCL2
,
MMP9
, and
IL18
gene expression did not change in response to weight loss. BG addition had no effect on any of the parameters studied.
Conclusions
Our data indicate that reduction in AT inflammation is not required for an improvement in insulin action during weight loss in subjects with uncomplicated obesity. BG does not have effects during dietary intervention.</description><subject>Adipose tissue</subject><subject>Adult</subject><subject>beta-Glucans - administration & dosage</subject><subject>beta-Glucans - pharmacology</subject><subject>Biopsy</subject><subject>Body weight loss</subject><subject>Caloric Restriction</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Gelatinase B</subject><subject>Gene expression</subject><subject>Gene Expression - drug effects</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hypocaloric diet</subject><subject>Immunomodulation</subject><subject>Inflammation</subject><subject>Inflammation - complications</subject><subject>Inflammation - genetics</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - pathology</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Insulin Resistance - genetics</subject><subject>Interleukin 1</subject><subject>Interleukin 18</subject><subject>Interleukin 6</subject><subject>Interleukin 6 receptors</subject><subject>Internal Medicine</subject><subject>Janus kinase</subject><subject>Janus kinase 2</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Monocyte chemoattractant protein 1</subject><subject>multidisciplinary</subject><subject>Nutrient deficiency</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - diet therapy</subject><subject>Obesity - genetics</subject><subject>Obesity - pathology</subject><subject>Original</subject><subject>Original Article</subject><subject>Science</subject><subject>Stat3 protein</subject><subject>Subcutaneous Fat - drug effects</subject><subject>Subcutaneous Fat - metabolism</subject><subject>Subcutaneous Fat - pathology</subject><subject>Weight control</subject><subject>Weight Loss - physiology</subject><subject>Young Adult</subject><subject>β-Glucan</subject><issn>1355-008X</issn><issn>1559-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><recordid>eNp1Ustu1DAUjRCIlsIHsEGW2LTSBPxI4mSDhKrykCqxmQU7y3GuMx4l9uBHy_Sz2PcX-CY8pJSHxMbX8j333HN9T1E8J_gVwZi_DoRiiktM2pI0pCtvHhTHpK67_ILxw3xndV1i3H4-Kp6EsMWYUtrwx8UR7TjjVVcdF7frDSDQGlRETqPZDeBlBHQNZtxENLkQVujaxA1y_md0KaJTskLs7HA2Z-X3b-U4JSUtksNgonF2hZxFIfUqRWnBpZAzZucCoGhCSICM1ZOcZxmd36MRbFbwdechhFyck2jvkh0PDNssKyztk1Vu3k1GZXUDcj0EE_dPi0daTgGe3cWTYv3uYn3-obz89P7j-dvLUlUcx1LXkraaNlXbKdkqxjg0He81phWtORtayYFVTUXw0EPPQPeso7RuesW6nmt2UrxZaHepn2FQYKOXk9h5M0u_F04a8XfGmo0Y3ZVocENIRzLB6R2Bd18ShChmExRM0_I_gmLW0Lwo1mXoy3-gW5e8zdNlFMdt3Vb1AUUWlPJ5Qx70vRiCxcEbYvGGyN4QB2-Im1zz4s8p7it-mSED6AIIOWVH8L9b_5_1B_hNyXQ</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Strączkowski, Marek</creator><creator>Nikołajuk, Agnieszka</creator><creator>Majewski, Radosław</creator><creator>Filarski, Remigiusz</creator><creator>Stefanowicz, Magdalena</creator><creator>Matulewicz, Natalia</creator><creator>Karczewska-Kupczewska, Monika</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180801</creationdate><title>The effect of moderate weight loss, with or without (1, 3)(1, 6)-β-glucan addition, on subcutaneous adipose tissue inflammatory gene expression in young subjects with uncomplicated obesity</title><author>Strączkowski, Marek ; Nikołajuk, Agnieszka ; Majewski, Radosław ; Filarski, Remigiusz ; Stefanowicz, Magdalena ; Matulewicz, Natalia ; Karczewska-Kupczewska, Monika</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-f5a28f26489ca8c337e697bf0242573d8a7e346410dbeb3efb392256bc39b7f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adipose tissue</topic><topic>Adult</topic><topic>beta-Glucans - administration & dosage</topic><topic>beta-Glucans - pharmacology</topic><topic>Biopsy</topic><topic>Body weight loss</topic><topic>Caloric Restriction</topic><topic>Diabetes</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Gelatinase B</topic><topic>Gene expression</topic><topic>Gene Expression - drug effects</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Hypocaloric diet</topic><topic>Immunomodulation</topic><topic>Inflammation</topic><topic>Inflammation - complications</topic><topic>Inflammation - genetics</topic><topic>Inflammation - metabolism</topic><topic>Inflammation - pathology</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Insulin Resistance - genetics</topic><topic>Interleukin 1</topic><topic>Interleukin 18</topic><topic>Interleukin 6</topic><topic>Interleukin 6 receptors</topic><topic>Internal Medicine</topic><topic>Janus kinase</topic><topic>Janus kinase 2</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Monocyte chemoattractant protein 1</topic><topic>multidisciplinary</topic><topic>Nutrient deficiency</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - diet therapy</topic><topic>Obesity - genetics</topic><topic>Obesity - pathology</topic><topic>Original</topic><topic>Original Article</topic><topic>Science</topic><topic>Stat3 protein</topic><topic>Subcutaneous Fat - drug effects</topic><topic>Subcutaneous Fat - metabolism</topic><topic>Subcutaneous Fat - pathology</topic><topic>Weight control</topic><topic>Weight Loss - physiology</topic><topic>Young Adult</topic><topic>β-Glucan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Strączkowski, Marek</creatorcontrib><creatorcontrib>Nikołajuk, Agnieszka</creatorcontrib><creatorcontrib>Majewski, Radosław</creatorcontrib><creatorcontrib>Filarski, Remigiusz</creatorcontrib><creatorcontrib>Stefanowicz, Magdalena</creatorcontrib><creatorcontrib>Matulewicz, Natalia</creatorcontrib><creatorcontrib>Karczewska-Kupczewska, Monika</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Strączkowski, Marek</au><au>Nikołajuk, Agnieszka</au><au>Majewski, Radosław</au><au>Filarski, Remigiusz</au><au>Stefanowicz, Magdalena</au><au>Matulewicz, Natalia</au><au>Karczewska-Kupczewska, Monika</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of moderate weight loss, with or without (1, 3)(1, 6)-β-glucan addition, on subcutaneous adipose tissue inflammatory gene expression in young subjects with uncomplicated obesity</atitle><jtitle>Endocrine</jtitle><stitle>Endocrine</stitle><addtitle>Endocrine</addtitle><date>2018-08-01</date><risdate>2018</risdate><volume>61</volume><issue>2</issue><spage>275</spage><epage>284</epage><pages>275-284</pages><issn>1355-008X</issn><eissn>1559-0100</eissn><abstract>Purpose
Obesity is characterized by insulin resistance and low-grade systemic and adipose tissue (AT) inflammation. It remains unclear whether beneficial effects of weight loss are related to AT inflammation. We aimed to assess the effect of weight loss during low-calorie diet on insulin sensitivity, AT expression of genes associated with inflammation in young subjects with obesity. Furthermore, we estimated the effects of immunomodulatory (1, 3)(1, 6)-β-glucan (BG) on the above parameters.
Methods
The study group comprised 52 subjects with obesity. Twelve-week dietary intervention was applied, with randomization to receive or not 500 mg BG daily. Euglycemic hyperinsulinemic clamp, subcutaneous AT biopsy were performed before and after the program. Twenty normal-weight subjects, examined at baseline, served as a control group.
Results
At baseline, obese subjects had lower insulin sensitivity, lower AT
ADIPOQ
,
JAK1
, and
JAK2
expression and higher AT expression of
LEP
,
IL6ST
,
STAT3
,
MIF
,
CCL2
,
MMP9
, and
IL18
. Forty obese subjects completed dietary intervention program, which resulted in 11.3% weight loss and 27% increase in insulin sensitivity (both
p
< 0.0001). AT
IL6R
,
IL6ST
,
JAK1
, and
JAK2
expression increased, whereas
MIF
,
CCL2
,
MMP9
, and
IL18
gene expression did not change in response to weight loss. BG addition had no effect on any of the parameters studied.
Conclusions
Our data indicate that reduction in AT inflammation is not required for an improvement in insulin action during weight loss in subjects with uncomplicated obesity. BG does not have effects during dietary intervention.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29737494</pmid><doi>10.1007/s12020-018-1619-z</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Endocrine, 2018-08, Vol.61 (2), p.275-284 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adipose tissue Adult beta-Glucans - administration & dosage beta-Glucans - pharmacology Biopsy Body weight loss Caloric Restriction Diabetes Endocrinology Female Gelatinase B Gene expression Gene Expression - drug effects Humanities and Social Sciences Humans Hypocaloric diet Immunomodulation Inflammation Inflammation - complications Inflammation - genetics Inflammation - metabolism Inflammation - pathology Insulin Insulin resistance Insulin Resistance - genetics Interleukin 1 Interleukin 18 Interleukin 6 Interleukin 6 receptors Internal Medicine Janus kinase Janus kinase 2 Male Medicine Medicine & Public Health Monocyte chemoattractant protein 1 multidisciplinary Nutrient deficiency Obesity Obesity - complications Obesity - diet therapy Obesity - genetics Obesity - pathology Original Original Article Science Stat3 protein Subcutaneous Fat - drug effects Subcutaneous Fat - metabolism Subcutaneous Fat - pathology Weight control Weight Loss - physiology Young Adult β-Glucan |
| title | The effect of moderate weight loss, with or without (1, 3)(1, 6)-β-glucan addition, on subcutaneous adipose tissue inflammatory gene expression in young subjects with uncomplicated obesity |
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