Effect of increasing fruit and vegetable intake by dietary intervention on nutritional biomarkers and attitudes to dietary change: a randomised trial
Purpose Low fruit and vegetable consumption is linked with an increased risk of death from vascular disease and cancer. The benefit of eating fruits and vegetables is attributed in part to antioxidants, vitamins and phytochemicals. Whether increasing intake impacts on markers of disease remains to b...
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| Veröffentlicht in: | European journal of nutrition 2018-08, Vol.57 (5), p.1855-1872 |
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| creator | Duthie, Susan J. Duthie, Garry G. Russell, Wendy R. Kyle, Janet A. M. Macdiarmid, Jennie I. Rungapamestry, Vanessa Stephen, Sylvia Megias-Baeza, Cristina Kaniewska, Joanna J. Shaw, Lindsey Milne, Lesley Bremner, David Ross, Karen Morrice, Philip Pirie, Lynn P. Horgan, Graham Bestwick, Charles S. |
| description | Purpose
Low fruit and vegetable consumption is linked with an increased risk of death from vascular disease and cancer. The benefit of eating fruits and vegetables is attributed in part to antioxidants, vitamins and phytochemicals. Whether increasing intake impacts on markers of disease remains to be established. This study investigates whether increasing daily intake of fruits, vegetables and juices from low (approx. 3 portions), to high intakes (approx. 8 portions) impacts on nutritional and clinical biomarkers. Barriers to achieving the recommended fruit and vegetable intakes are also investigated.
Method
In a randomised clinical trial, the participants [19 men and 26 women (39–58 years)] with low reported fruit, juice and vegetable intake ( |
| doi_str_mv | 10.1007/s00394-017-1469-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6060837</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2101341276</sourcerecordid><originalsourceid>FETCH-LOGICAL-c503t-a7ee265c4fb3324f720db18322dfeea83061a4b828295ed33c371a1c14d289b73</originalsourceid><addsrcrecordid>eNqFksuKFTEQhhtRnHH0AdxIwI2b1sqlk24XggzjBQbc6Dqkk8qZzPTpjEn6wHkQ39e0ZzxeQIRALvXVn6rkb5qnFF5SAPUqA_BBtEBVS4UcWrjXnFLBZSsZ7e4f16BOmkc5XwMA45I-bE5Y30nogJ823y68R1tI9CTMNqHJYd4Qn5ZQiJkd2eEGixknrOFibpCMe-JCPUr79QTTDucS4kzqmJeSwroxExlD3Jp0gyn_kDGlhLI4zKTEY769MvMGXxNDUmXiNmR0pEqY6XHzwJsp45O7-az58u7i8_mH9vLT-4_nby9bW4svrVGITHZW-JFzJrxi4Ebac8acRzQ9B0mNGHvWs6FDx7nlihpqqXCsH0bFz5o3B93bZdyis7WXZCZ9m0Itfq-jCfrPyByu9CbutAQJPV8FXtwJpPh1wVx07cLiNJkZ45I1o0C5oEzJ_6J0AMFgkN1Q0ed_oddxSfVZqyAokAMMwCtFD5RNMeeE_lg3Bb36Qx_8oas_9OoPDTXn2e8NHzN-GqIC7ADkGqq_k35d_W_V7wMSyKM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2070690903</pqid></control><display><type>article</type><title>Effect of increasing fruit and vegetable intake by dietary intervention on nutritional biomarkers and attitudes to dietary change: a randomised trial</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Duthie, Susan J. ; Duthie, Garry G. ; Russell, Wendy R. ; Kyle, Janet A. M. ; Macdiarmid, Jennie I. ; Rungapamestry, Vanessa ; Stephen, Sylvia ; Megias-Baeza, Cristina ; Kaniewska, Joanna J. ; Shaw, Lindsey ; Milne, Lesley ; Bremner, David ; Ross, Karen ; Morrice, Philip ; Pirie, Lynn P. ; Horgan, Graham ; Bestwick, Charles S.</creator><creatorcontrib>Duthie, Susan J. ; Duthie, Garry G. ; Russell, Wendy R. ; Kyle, Janet A. M. ; Macdiarmid, Jennie I. ; Rungapamestry, Vanessa ; Stephen, Sylvia ; Megias-Baeza, Cristina ; Kaniewska, Joanna J. ; Shaw, Lindsey ; Milne, Lesley ; Bremner, David ; Ross, Karen ; Morrice, Philip ; Pirie, Lynn P. ; Horgan, Graham ; Bestwick, Charles S.</creatorcontrib><description>Purpose
Low fruit and vegetable consumption is linked with an increased risk of death from vascular disease and cancer. The benefit of eating fruits and vegetables is attributed in part to antioxidants, vitamins and phytochemicals. Whether increasing intake impacts on markers of disease remains to be established. This study investigates whether increasing daily intake of fruits, vegetables and juices from low (approx. 3 portions), to high intakes (approx. 8 portions) impacts on nutritional and clinical biomarkers. Barriers to achieving the recommended fruit and vegetable intakes are also investigated.
Method
In a randomised clinical trial, the participants [19 men and 26 women (39–58 years)] with low reported fruit, juice and vegetable intake (<3 portions/day) were randomised to consume either their usual diet or a diet supplemented with an additional 480 g of fruit and vegetables and fruit juice (300 ml) daily for 12 weeks. Nutritional biomarkers (vitamin C, carotenoids, B vitamins), antioxidant capacity and genomic stability were measured pre-intervention, at 4-, 8- and 12 weeks throughout the intervention. Samples were also taken post-intervention after a 6-week washout period. Glucose, homocysteine, lipids, blood pressure, weight and arterial stiffness were also measured. Intake of fruit, fruit juice and vegetables was reassessed 12 months after conducting the study and a questionnaire was developed to identify barriers to healthy eating.
Results
Intake increased significantly in the intervention group compared to controls, achieving 8.4 portions/day after 12 weeks. Plasma vitamin C (35%), folate (15%) and certain carotenoids [α-carotene (50%) and β-carotene (70%) and lutein/zeaxanthin (70%)] were significantly increased (
P
< 0.05) in the intervention group. There were no significant changes in antioxidant capacity, DNA damage and markers of vascular health. Barriers to achieving recommended intakes of fruits and vegetables measured 12 months after the intervention period were amount, inconvenience and cost.
Conclusion
While increasing fruit, juice and vegetable consumption increases circulating level of beneficial nutrients in healthy subjects, a 12-week intervention was not associated with effects on antioxidant status or lymphocyte DNA damage.
Trial registration
This trial was registered at Controlled-Trials.com; registration ISRCTN71368072.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-017-1469-0</identifier><identifier>PMID: 28560503</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; alpha-carotene ; antioxidant activity ; Antioxidants ; Antioxidants - metabolism ; Ascorbic acid ; Attitude ; attitudes and opinions ; beta-carotene ; Biomarkers ; Biomarkers - blood ; Blood pressure ; Cancer ; Carotenoids ; Chemistry ; Chemistry and Materials Science ; Clinical trials ; death ; Diet ; Dietary intake ; DNA damage ; Evidence-based medicine ; Female ; Folic acid ; Fruit ; Fruit juices ; Fruits ; genomics ; glucose ; healthy diet ; Homocysteine ; Humans ; ISRCTN ; ISRCTN71368072 ; Lipids ; lutein ; Male ; men ; Middle Aged ; neoplasms ; Nutrients ; Nutrition ; nutritional intervention ; Nutritional Status ; Original Contribution ; phytopharmaceuticals ; questionnaires ; randomized clinical trials ; risk ; Vascular diseases ; vegetable consumption ; Vegetables ; Vitamin C ; Vitamins ; Vitamins - blood ; women ; Zeaxanthin ; β-Carotene</subject><ispartof>European journal of nutrition, 2018-08, Vol.57 (5), p.1855-1872</ispartof><rights>The Author(s) 2017</rights><rights>European Journal of Nutrition is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-a7ee265c4fb3324f720db18322dfeea83061a4b828295ed33c371a1c14d289b73</citedby><cites>FETCH-LOGICAL-c503t-a7ee265c4fb3324f720db18322dfeea83061a4b828295ed33c371a1c14d289b73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00394-017-1469-0$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00394-017-1469-0$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28560503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duthie, Susan J.</creatorcontrib><creatorcontrib>Duthie, Garry G.</creatorcontrib><creatorcontrib>Russell, Wendy R.</creatorcontrib><creatorcontrib>Kyle, Janet A. M.</creatorcontrib><creatorcontrib>Macdiarmid, Jennie I.</creatorcontrib><creatorcontrib>Rungapamestry, Vanessa</creatorcontrib><creatorcontrib>Stephen, Sylvia</creatorcontrib><creatorcontrib>Megias-Baeza, Cristina</creatorcontrib><creatorcontrib>Kaniewska, Joanna J.</creatorcontrib><creatorcontrib>Shaw, Lindsey</creatorcontrib><creatorcontrib>Milne, Lesley</creatorcontrib><creatorcontrib>Bremner, David</creatorcontrib><creatorcontrib>Ross, Karen</creatorcontrib><creatorcontrib>Morrice, Philip</creatorcontrib><creatorcontrib>Pirie, Lynn P.</creatorcontrib><creatorcontrib>Horgan, Graham</creatorcontrib><creatorcontrib>Bestwick, Charles S.</creatorcontrib><title>Effect of increasing fruit and vegetable intake by dietary intervention on nutritional biomarkers and attitudes to dietary change: a randomised trial</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>Purpose
Low fruit and vegetable consumption is linked with an increased risk of death from vascular disease and cancer. The benefit of eating fruits and vegetables is attributed in part to antioxidants, vitamins and phytochemicals. Whether increasing intake impacts on markers of disease remains to be established. This study investigates whether increasing daily intake of fruits, vegetables and juices from low (approx. 3 portions), to high intakes (approx. 8 portions) impacts on nutritional and clinical biomarkers. Barriers to achieving the recommended fruit and vegetable intakes are also investigated.
Method
In a randomised clinical trial, the participants [19 men and 26 women (39–58 years)] with low reported fruit, juice and vegetable intake (<3 portions/day) were randomised to consume either their usual diet or a diet supplemented with an additional 480 g of fruit and vegetables and fruit juice (300 ml) daily for 12 weeks. Nutritional biomarkers (vitamin C, carotenoids, B vitamins), antioxidant capacity and genomic stability were measured pre-intervention, at 4-, 8- and 12 weeks throughout the intervention. Samples were also taken post-intervention after a 6-week washout period. Glucose, homocysteine, lipids, blood pressure, weight and arterial stiffness were also measured. Intake of fruit, fruit juice and vegetables was reassessed 12 months after conducting the study and a questionnaire was developed to identify barriers to healthy eating.
Results
Intake increased significantly in the intervention group compared to controls, achieving 8.4 portions/day after 12 weeks. Plasma vitamin C (35%), folate (15%) and certain carotenoids [α-carotene (50%) and β-carotene (70%) and lutein/zeaxanthin (70%)] were significantly increased (
P
< 0.05) in the intervention group. There were no significant changes in antioxidant capacity, DNA damage and markers of vascular health. Barriers to achieving recommended intakes of fruits and vegetables measured 12 months after the intervention period were amount, inconvenience and cost.
Conclusion
While increasing fruit, juice and vegetable consumption increases circulating level of beneficial nutrients in healthy subjects, a 12-week intervention was not associated with effects on antioxidant status or lymphocyte DNA damage.
Trial registration
This trial was registered at Controlled-Trials.com; registration ISRCTN71368072.</description><subject>Adult</subject><subject>alpha-carotene</subject><subject>antioxidant activity</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Ascorbic acid</subject><subject>Attitude</subject><subject>attitudes and opinions</subject><subject>beta-carotene</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood pressure</subject><subject>Cancer</subject><subject>Carotenoids</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Clinical trials</subject><subject>death</subject><subject>Diet</subject><subject>Dietary intake</subject><subject>DNA damage</subject><subject>Evidence-based medicine</subject><subject>Female</subject><subject>Folic acid</subject><subject>Fruit</subject><subject>Fruit juices</subject><subject>Fruits</subject><subject>genomics</subject><subject>glucose</subject><subject>healthy diet</subject><subject>Homocysteine</subject><subject>Humans</subject><subject>ISRCTN</subject><subject>ISRCTN71368072</subject><subject>Lipids</subject><subject>lutein</subject><subject>Male</subject><subject>men</subject><subject>Middle Aged</subject><subject>neoplasms</subject><subject>Nutrients</subject><subject>Nutrition</subject><subject>nutritional intervention</subject><subject>Nutritional Status</subject><subject>Original Contribution</subject><subject>phytopharmaceuticals</subject><subject>questionnaires</subject><subject>randomized clinical trials</subject><subject>risk</subject><subject>Vascular diseases</subject><subject>vegetable consumption</subject><subject>Vegetables</subject><subject>Vitamin C</subject><subject>Vitamins</subject><subject>Vitamins - blood</subject><subject>women</subject><subject>Zeaxanthin</subject><subject>β-Carotene</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFksuKFTEQhhtRnHH0AdxIwI2b1sqlk24XggzjBQbc6Dqkk8qZzPTpjEn6wHkQ39e0ZzxeQIRALvXVn6rkb5qnFF5SAPUqA_BBtEBVS4UcWrjXnFLBZSsZ7e4f16BOmkc5XwMA45I-bE5Y30nogJ823y68R1tI9CTMNqHJYd4Qn5ZQiJkd2eEGixknrOFibpCMe-JCPUr79QTTDucS4kzqmJeSwroxExlD3Jp0gyn_kDGlhLI4zKTEY769MvMGXxNDUmXiNmR0pEqY6XHzwJsp45O7-az58u7i8_mH9vLT-4_nby9bW4svrVGITHZW-JFzJrxi4Ebac8acRzQ9B0mNGHvWs6FDx7nlihpqqXCsH0bFz5o3B93bZdyis7WXZCZ9m0Itfq-jCfrPyByu9CbutAQJPV8FXtwJpPh1wVx07cLiNJkZ45I1o0C5oEzJ_6J0AMFgkN1Q0ed_oddxSfVZqyAokAMMwCtFD5RNMeeE_lg3Bb36Qx_8oas_9OoPDTXn2e8NHzN-GqIC7ADkGqq_k35d_W_V7wMSyKM</recordid><startdate>20180801</startdate><enddate>20180801</enddate><creator>Duthie, Susan J.</creator><creator>Duthie, Garry G.</creator><creator>Russell, Wendy R.</creator><creator>Kyle, Janet A. 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M. ; Macdiarmid, Jennie I. ; Rungapamestry, Vanessa ; Stephen, Sylvia ; Megias-Baeza, Cristina ; Kaniewska, Joanna J. ; Shaw, Lindsey ; Milne, Lesley ; Bremner, David ; Ross, Karen ; Morrice, Philip ; Pirie, Lynn P. ; Horgan, Graham ; Bestwick, Charles S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-a7ee265c4fb3324f720db18322dfeea83061a4b828295ed33c371a1c14d289b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>alpha-carotene</topic><topic>antioxidant activity</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Ascorbic acid</topic><topic>Attitude</topic><topic>attitudes and opinions</topic><topic>beta-carotene</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Blood pressure</topic><topic>Cancer</topic><topic>Carotenoids</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Clinical trials</topic><topic>death</topic><topic>Diet</topic><topic>Dietary intake</topic><topic>DNA damage</topic><topic>Evidence-based medicine</topic><topic>Female</topic><topic>Folic acid</topic><topic>Fruit</topic><topic>Fruit juices</topic><topic>Fruits</topic><topic>genomics</topic><topic>glucose</topic><topic>healthy diet</topic><topic>Homocysteine</topic><topic>Humans</topic><topic>ISRCTN</topic><topic>ISRCTN71368072</topic><topic>Lipids</topic><topic>lutein</topic><topic>Male</topic><topic>men</topic><topic>Middle Aged</topic><topic>neoplasms</topic><topic>Nutrients</topic><topic>Nutrition</topic><topic>nutritional intervention</topic><topic>Nutritional Status</topic><topic>Original Contribution</topic><topic>phytopharmaceuticals</topic><topic>questionnaires</topic><topic>randomized clinical trials</topic><topic>risk</topic><topic>Vascular diseases</topic><topic>vegetable consumption</topic><topic>Vegetables</topic><topic>Vitamin C</topic><topic>Vitamins</topic><topic>Vitamins - blood</topic><topic>women</topic><topic>Zeaxanthin</topic><topic>β-Carotene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duthie, Susan J.</creatorcontrib><creatorcontrib>Duthie, Garry G.</creatorcontrib><creatorcontrib>Russell, Wendy R.</creatorcontrib><creatorcontrib>Kyle, Janet A. M.</creatorcontrib><creatorcontrib>Macdiarmid, Jennie I.</creatorcontrib><creatorcontrib>Rungapamestry, Vanessa</creatorcontrib><creatorcontrib>Stephen, Sylvia</creatorcontrib><creatorcontrib>Megias-Baeza, Cristina</creatorcontrib><creatorcontrib>Kaniewska, Joanna J.</creatorcontrib><creatorcontrib>Shaw, Lindsey</creatorcontrib><creatorcontrib>Milne, Lesley</creatorcontrib><creatorcontrib>Bremner, David</creatorcontrib><creatorcontrib>Ross, Karen</creatorcontrib><creatorcontrib>Morrice, Philip</creatorcontrib><creatorcontrib>Pirie, Lynn P.</creatorcontrib><creatorcontrib>Horgan, Graham</creatorcontrib><creatorcontrib>Bestwick, Charles S.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duthie, Susan J.</au><au>Duthie, Garry G.</au><au>Russell, Wendy R.</au><au>Kyle, Janet A. M.</au><au>Macdiarmid, Jennie I.</au><au>Rungapamestry, Vanessa</au><au>Stephen, Sylvia</au><au>Megias-Baeza, Cristina</au><au>Kaniewska, Joanna J.</au><au>Shaw, Lindsey</au><au>Milne, Lesley</au><au>Bremner, David</au><au>Ross, Karen</au><au>Morrice, Philip</au><au>Pirie, Lynn P.</au><au>Horgan, Graham</au><au>Bestwick, Charles S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of increasing fruit and vegetable intake by dietary intervention on nutritional biomarkers and attitudes to dietary change: a randomised trial</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2018-08-01</date><risdate>2018</risdate><volume>57</volume><issue>5</issue><spage>1855</spage><epage>1872</epage><pages>1855-1872</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>Purpose
Low fruit and vegetable consumption is linked with an increased risk of death from vascular disease and cancer. The benefit of eating fruits and vegetables is attributed in part to antioxidants, vitamins and phytochemicals. Whether increasing intake impacts on markers of disease remains to be established. This study investigates whether increasing daily intake of fruits, vegetables and juices from low (approx. 3 portions), to high intakes (approx. 8 portions) impacts on nutritional and clinical biomarkers. Barriers to achieving the recommended fruit and vegetable intakes are also investigated.
Method
In a randomised clinical trial, the participants [19 men and 26 women (39–58 years)] with low reported fruit, juice and vegetable intake (<3 portions/day) were randomised to consume either their usual diet or a diet supplemented with an additional 480 g of fruit and vegetables and fruit juice (300 ml) daily for 12 weeks. Nutritional biomarkers (vitamin C, carotenoids, B vitamins), antioxidant capacity and genomic stability were measured pre-intervention, at 4-, 8- and 12 weeks throughout the intervention. Samples were also taken post-intervention after a 6-week washout period. Glucose, homocysteine, lipids, blood pressure, weight and arterial stiffness were also measured. Intake of fruit, fruit juice and vegetables was reassessed 12 months after conducting the study and a questionnaire was developed to identify barriers to healthy eating.
Results
Intake increased significantly in the intervention group compared to controls, achieving 8.4 portions/day after 12 weeks. Plasma vitamin C (35%), folate (15%) and certain carotenoids [α-carotene (50%) and β-carotene (70%) and lutein/zeaxanthin (70%)] were significantly increased (
P
< 0.05) in the intervention group. There were no significant changes in antioxidant capacity, DNA damage and markers of vascular health. Barriers to achieving recommended intakes of fruits and vegetables measured 12 months after the intervention period were amount, inconvenience and cost.
Conclusion
While increasing fruit, juice and vegetable consumption increases circulating level of beneficial nutrients in healthy subjects, a 12-week intervention was not associated with effects on antioxidant status or lymphocyte DNA damage.
Trial registration
This trial was registered at Controlled-Trials.com; registration ISRCTN71368072.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>28560503</pmid><doi>10.1007/s00394-017-1469-0</doi><tpages>18</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1436-6207 |
| ispartof | European journal of nutrition, 2018-08, Vol.57 (5), p.1855-1872 |
| issn | 1436-6207 1436-6215 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6060837 |
| source | MEDLINE; SpringerLink Journals |
| subjects | Adult alpha-carotene antioxidant activity Antioxidants Antioxidants - metabolism Ascorbic acid Attitude attitudes and opinions beta-carotene Biomarkers Biomarkers - blood Blood pressure Cancer Carotenoids Chemistry Chemistry and Materials Science Clinical trials death Diet Dietary intake DNA damage Evidence-based medicine Female Folic acid Fruit Fruit juices Fruits genomics glucose healthy diet Homocysteine Humans ISRCTN ISRCTN71368072 Lipids lutein Male men Middle Aged neoplasms Nutrients Nutrition nutritional intervention Nutritional Status Original Contribution phytopharmaceuticals questionnaires randomized clinical trials risk Vascular diseases vegetable consumption Vegetables Vitamin C Vitamins Vitamins - blood women Zeaxanthin β-Carotene |
| title | Effect of increasing fruit and vegetable intake by dietary intervention on nutritional biomarkers and attitudes to dietary change: a randomised trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T10%3A55%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20increasing%20fruit%20and%20vegetable%20intake%20by%20dietary%20intervention%20on%20nutritional%20biomarkers%20and%20attitudes%20to%20dietary%20change:%20a%20randomised%20trial&rft.jtitle=European%20journal%20of%20nutrition&rft.au=Duthie,%20Susan%20J.&rft.date=2018-08-01&rft.volume=57&rft.issue=5&rft.spage=1855&rft.epage=1872&rft.pages=1855-1872&rft.issn=1436-6207&rft.eissn=1436-6215&rft_id=info:doi/10.1007/s00394-017-1469-0&rft_dat=%3Cproquest_pubme%3E2101341276%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2070690903&rft_id=info:pmid/28560503&rfr_iscdi=true |