Ex vivo anti-inflammatory effects of probiotics for periodontal health
Background: Probiotic bacteria with anti-inflammatory properties have the potential to be of therapeutic benefit in gingivitis. Objective: To evaluate the effects of potential probiotic strains on inflammatory mediators involved in early gingivitis using an ex vivo inflammation model. Methods: Strai...
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| Veröffentlicht in: | Journal of oral microbiology 2018-01, Vol.10 (1), p.1502027-10 |
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| creator | Schmitter, Tim Fiebich, Bernd L. Fischer, Joerg T. Gajfulin, Max Larsson, Niklas Rose, Thorsten Goetz, Marcus R. |
| description | Background: Probiotic bacteria with anti-inflammatory properties have the potential to be of therapeutic benefit in gingivitis.
Objective: To evaluate the effects of potential probiotic strains on inflammatory mediators involved in early gingivitis using an ex vivo inflammation model.
Methods: Strains were screened in viable and attenuated forms for effects on bacterial lipopolysaccharide (LPS)-stimulated release of interleukins (IL)-1β, -6 and -8, tumor necrosis factor-α, prostaglandin E
2
and 8-isoprostane from human primary monocytes, and then, if anti-inflammatory effects were shown, on IL-1β-stimulated release of inflammatory mediators from primary gingival fibroblasts. Lead strains were evaluated for optimal dosing, batch-to-batch variation and functional consistency in toothpaste.
Results: Twenty-one of 73 strains showed anti-inflammatory effects in monocytes; of which, seven showed effects in both viable and attenuated forms. Seven of 14 strains showed effects in fibroblasts. Strains Lactobacillus paracasei LPc-G110(SYBIO-15) and Lactobacillus plantarum GOS42(SYBIO-41) induced statistically significant dose-dependent reductions in the release of multiple inflammatory mediators from monocytes, which were consistent across batches. Viable L. paracasei LPc-G110 tooth paste significantly reduced IL-6, IL-8 and prostaglandin E
2
release from monocytes versus placebo.
Conclusion: Strains L. paracasei LPc-G110 and L. plantarum GOS42 have potential for use as probiotics in oral care products to reduce gingival inflammation. |
| doi_str_mv | 10.1080/20002297.2018.1502027 |
| format | Article |
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Objective: To evaluate the effects of potential probiotic strains on inflammatory mediators involved in early gingivitis using an ex vivo inflammation model.
Methods: Strains were screened in viable and attenuated forms for effects on bacterial lipopolysaccharide (LPS)-stimulated release of interleukins (IL)-1β, -6 and -8, tumor necrosis factor-α, prostaglandin E
2
and 8-isoprostane from human primary monocytes, and then, if anti-inflammatory effects were shown, on IL-1β-stimulated release of inflammatory mediators from primary gingival fibroblasts. Lead strains were evaluated for optimal dosing, batch-to-batch variation and functional consistency in toothpaste.
Results: Twenty-one of 73 strains showed anti-inflammatory effects in monocytes; of which, seven showed effects in both viable and attenuated forms. Seven of 14 strains showed effects in fibroblasts. Strains Lactobacillus paracasei LPc-G110(SYBIO-15) and Lactobacillus plantarum GOS42(SYBIO-41) induced statistically significant dose-dependent reductions in the release of multiple inflammatory mediators from monocytes, which were consistent across batches. Viable L. paracasei LPc-G110 tooth paste significantly reduced IL-6, IL-8 and prostaglandin E
2
release from monocytes versus placebo.
Conclusion: Strains L. paracasei LPc-G110 and L. plantarum GOS42 have potential for use as probiotics in oral care products to reduce gingival inflammation.</description><identifier>ISSN: 2000-2297</identifier><identifier>EISSN: 2000-2297</identifier><identifier>DOI: 10.1080/20002297.2018.1502027</identifier><identifier>PMID: 30057719</identifier><language>eng</language><publisher>United States: Taylor & Francis</publisher><subject>Anti-inflammatory agents ; Bacteria ; Biofilms ; Cytokines ; Dental plaque ; Disease ; Dosage ; Fibroblasts ; Gene expression ; Gingivitis ; IL-1β ; Inflammation ; Interleukin 1 ; Interleukin 6 ; Interleukin 8 ; Lactobacillus paracasei ; Lactobacillus plantarum ; Lipopolysaccharides ; Microbiota ; Monocytes ; Oral hygiene ; Original ; Periodontics ; Probiotics ; Prostaglandin E2 ; Statistical analysis ; Strains (organisms) ; Teeth ; Toothpaste ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α</subject><ispartof>Journal of oral microbiology, 2018-01, Vol.10 (1), p.1502027-10</ispartof><rights>2018 European Regional Development Fund 2018</rights><rights>Copyright Taylor & Francis Ltd. 2018</rights><rights>2018 European Regional Development Fund. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2018 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c590t-82208e456f48fbd6f4ecda393de1c20100c1f9367a34db2c7f48b7936952d1593</citedby><cites>FETCH-LOGICAL-c590t-82208e456f48fbd6f4ecda393de1c20100c1f9367a34db2c7f48b7936952d1593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060379/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060379/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,27479,27901,27902,53766,53768,59116,59117</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30057719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schmitter, Tim</creatorcontrib><creatorcontrib>Fiebich, Bernd L.</creatorcontrib><creatorcontrib>Fischer, Joerg T.</creatorcontrib><creatorcontrib>Gajfulin, Max</creatorcontrib><creatorcontrib>Larsson, Niklas</creatorcontrib><creatorcontrib>Rose, Thorsten</creatorcontrib><creatorcontrib>Goetz, Marcus R.</creatorcontrib><title>Ex vivo anti-inflammatory effects of probiotics for periodontal health</title><title>Journal of oral microbiology</title><addtitle>J Oral Microbiol</addtitle><description>Background: Probiotic bacteria with anti-inflammatory properties have the potential to be of therapeutic benefit in gingivitis.
Objective: To evaluate the effects of potential probiotic strains on inflammatory mediators involved in early gingivitis using an ex vivo inflammation model.
Methods: Strains were screened in viable and attenuated forms for effects on bacterial lipopolysaccharide (LPS)-stimulated release of interleukins (IL)-1β, -6 and -8, tumor necrosis factor-α, prostaglandin E
2
and 8-isoprostane from human primary monocytes, and then, if anti-inflammatory effects were shown, on IL-1β-stimulated release of inflammatory mediators from primary gingival fibroblasts. Lead strains were evaluated for optimal dosing, batch-to-batch variation and functional consistency in toothpaste.
Results: Twenty-one of 73 strains showed anti-inflammatory effects in monocytes; of which, seven showed effects in both viable and attenuated forms. Seven of 14 strains showed effects in fibroblasts. Strains Lactobacillus paracasei LPc-G110(SYBIO-15) and Lactobacillus plantarum GOS42(SYBIO-41) induced statistically significant dose-dependent reductions in the release of multiple inflammatory mediators from monocytes, which were consistent across batches. Viable L. paracasei LPc-G110 tooth paste significantly reduced IL-6, IL-8 and prostaglandin E
2
release from monocytes versus placebo.
Conclusion: Strains L. paracasei LPc-G110 and L. plantarum GOS42 have potential for use as probiotics in oral care products to reduce gingival inflammation.</description><subject>Anti-inflammatory agents</subject><subject>Bacteria</subject><subject>Biofilms</subject><subject>Cytokines</subject><subject>Dental plaque</subject><subject>Disease</subject><subject>Dosage</subject><subject>Fibroblasts</subject><subject>Gene expression</subject><subject>Gingivitis</subject><subject>IL-1β</subject><subject>Inflammation</subject><subject>Interleukin 1</subject><subject>Interleukin 6</subject><subject>Interleukin 8</subject><subject>Lactobacillus paracasei</subject><subject>Lactobacillus plantarum</subject><subject>Lipopolysaccharides</subject><subject>Microbiota</subject><subject>Monocytes</subject><subject>Oral hygiene</subject><subject>Original</subject><subject>Periodontics</subject><subject>Probiotics</subject><subject>Prostaglandin E2</subject><subject>Statistical analysis</subject><subject>Strains (organisms)</subject><subject>Teeth</subject><subject>Toothpaste</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><issn>2000-2297</issn><issn>2000-2297</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNp9kk1v1DAQhiMEolXpTwBF4sIly_hrHV8QqOqXVIkLnC3HHne9SuLFzi7sv8dht1XLoSfbM49fz4zfqnpPYEGghc8UAChVckGBtAsigAKVr6rTOd7MiddP9ifVec7rcgJG25bTt9UJAxBSEnVaXV3-qXdhF2szTqEJo-_NMJgppn2N3qOdch19vUmxC3EKNtc-pnqDKUQXx8n09QpNP63eVW-86TOeH9ez6ufV5Y-Lm-bu-_Xtxbe7xgoFU9NSCi1ysfS89Z0rC1pnmGIOiS29AFjiFVtKw7jrqJWF62QJKEEdEYqdVbcHXRfNWm9SGEza62iC_heI6V6bVOrsUXPOlwDcIQrBUbSGc2vK1GSnEJ3EovXloLXZdgM6i-OUTP9M9HlmDCt9H3d6CUtgci7m01EgxV9bzJMeQrbY92bEuM2aglRKMEZm9ON_6Dpu01hGpSkpjJK8fM-LlCSEEkZkocSBsinmnNA_lkxAz_bQD_bQsz300R7l3oen_T7eejBDAb4egGKDmAbzO6be6cns-5h8MqMNWbOX3_gLvFzHaQ</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Schmitter, Tim</creator><creator>Fiebich, Bernd L.</creator><creator>Fischer, Joerg T.</creator><creator>Gajfulin, Max</creator><creator>Larsson, Niklas</creator><creator>Rose, Thorsten</creator><creator>Goetz, Marcus R.</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7T7</scope><scope>7X7</scope><scope>7XB</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20180101</creationdate><title>Ex vivo anti-inflammatory effects of probiotics for periodontal health</title><author>Schmitter, Tim ; Fiebich, Bernd L. ; Fischer, Joerg T. ; Gajfulin, Max ; Larsson, Niklas ; Rose, Thorsten ; Goetz, Marcus R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c590t-82208e456f48fbd6f4ecda393de1c20100c1f9367a34db2c7f48b7936952d1593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Anti-inflammatory agents</topic><topic>Bacteria</topic><topic>Biofilms</topic><topic>Cytokines</topic><topic>Dental plaque</topic><topic>Disease</topic><topic>Dosage</topic><topic>Fibroblasts</topic><topic>Gene expression</topic><topic>Gingivitis</topic><topic>IL-1β</topic><topic>Inflammation</topic><topic>Interleukin 1</topic><topic>Interleukin 6</topic><topic>Interleukin 8</topic><topic>Lactobacillus paracasei</topic><topic>Lactobacillus plantarum</topic><topic>Lipopolysaccharides</topic><topic>Microbiota</topic><topic>Monocytes</topic><topic>Oral hygiene</topic><topic>Original</topic><topic>Periodontics</topic><topic>Probiotics</topic><topic>Prostaglandin E2</topic><topic>Statistical analysis</topic><topic>Strains (organisms)</topic><topic>Teeth</topic><topic>Toothpaste</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schmitter, Tim</creatorcontrib><creatorcontrib>Fiebich, Bernd L.</creatorcontrib><creatorcontrib>Fischer, Joerg T.</creatorcontrib><creatorcontrib>Gajfulin, Max</creatorcontrib><creatorcontrib>Larsson, Niklas</creatorcontrib><creatorcontrib>Rose, Thorsten</creatorcontrib><creatorcontrib>Goetz, Marcus R.</creatorcontrib><collection>Taylor & Francis Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of oral microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schmitter, Tim</au><au>Fiebich, Bernd L.</au><au>Fischer, Joerg T.</au><au>Gajfulin, Max</au><au>Larsson, Niklas</au><au>Rose, Thorsten</au><au>Goetz, Marcus R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ex vivo anti-inflammatory effects of probiotics for periodontal health</atitle><jtitle>Journal of oral microbiology</jtitle><addtitle>J Oral Microbiol</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>10</volume><issue>1</issue><spage>1502027</spage><epage>10</epage><pages>1502027-10</pages><issn>2000-2297</issn><eissn>2000-2297</eissn><abstract>Background: Probiotic bacteria with anti-inflammatory properties have the potential to be of therapeutic benefit in gingivitis.
Objective: To evaluate the effects of potential probiotic strains on inflammatory mediators involved in early gingivitis using an ex vivo inflammation model.
Methods: Strains were screened in viable and attenuated forms for effects on bacterial lipopolysaccharide (LPS)-stimulated release of interleukins (IL)-1β, -6 and -8, tumor necrosis factor-α, prostaglandin E
2
and 8-isoprostane from human primary monocytes, and then, if anti-inflammatory effects were shown, on IL-1β-stimulated release of inflammatory mediators from primary gingival fibroblasts. Lead strains were evaluated for optimal dosing, batch-to-batch variation and functional consistency in toothpaste.
Results: Twenty-one of 73 strains showed anti-inflammatory effects in monocytes; of which, seven showed effects in both viable and attenuated forms. Seven of 14 strains showed effects in fibroblasts. Strains Lactobacillus paracasei LPc-G110(SYBIO-15) and Lactobacillus plantarum GOS42(SYBIO-41) induced statistically significant dose-dependent reductions in the release of multiple inflammatory mediators from monocytes, which were consistent across batches. Viable L. paracasei LPc-G110 tooth paste significantly reduced IL-6, IL-8 and prostaglandin E
2
release from monocytes versus placebo.
Conclusion: Strains L. paracasei LPc-G110 and L. plantarum GOS42 have potential for use as probiotics in oral care products to reduce gingival inflammation.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>30057719</pmid><doi>10.1080/20002297.2018.1502027</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | Taylor & Francis Open Access; DOAJ Directory of Open Access Journals; Co-Action Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Anti-inflammatory agents Bacteria Biofilms Cytokines Dental plaque Disease Dosage Fibroblasts Gene expression Gingivitis IL-1β Inflammation Interleukin 1 Interleukin 6 Interleukin 8 Lactobacillus paracasei Lactobacillus plantarum Lipopolysaccharides Microbiota Monocytes Oral hygiene Original Periodontics Probiotics Prostaglandin E2 Statistical analysis Strains (organisms) Teeth Toothpaste Tumor necrosis factor-TNF Tumor necrosis factor-α |
| title | Ex vivo anti-inflammatory effects of probiotics for periodontal health |
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