Advanced Atherosclerosis with Leriche Syndrome, in a Patient with Carney Complex
Carney complex (CNC) is a rare autosomal dominant syndrome. Spotty skin pigmentation is the major clinical manifestation of CNC, followed by cardiac myxomas, benign tumors that usually present with features from the classical triad of obstructive cardiac, embolic and non-specific constitutional symp...
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| Veröffentlicht in: | Mædica 2018-06, Vol.13 (2), p.147-151 |
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| creator | Visoiu, Ionela-Simona Constantinescu, Cristina Patrascu, Natalia Stoicescu, Claudiu Ionut Dorobat, Bogdan Brezeanu, Radu Anton, Cristina Vinereanu, Dragos Cinteza, Mircea |
| description | Carney complex (CNC) is a rare autosomal dominant syndrome. Spotty skin pigmentation is the major clinical manifestation of CNC, followed by cardiac myxomas, benign tumors that usually present with features from the classical triad of obstructive cardiac, embolic and non-specific constitutional symptoms (NCS). NCS are caused by the overproduction of interleukin-6 (IL-6), a pro-inflammatory cytokine which mediates the induction of intercellular adhesion molecule 1 (ICAM-1) and promotes endothelial dysfunction and atherosclerosis. Thus, myxomas may be directly linked to an increased risk of atherosclerotic events. We report here a case of a 74-year-old woman with left atrial myxoma, skin pigmentary abnormalities, thyroid disorder and extensive atherosclerosis, with non-embolic occlusion of infrarenal abdominal aorta. |
| doi_str_mv | 10.26574/maedica.2018.13.2.147 |
| format | Article |
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| title | Advanced Atherosclerosis with Leriche Syndrome, in a Patient with Carney Complex |
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