Pontin/Tip49 negatively regulates JNK-mediated cell death in Drosophila

Pontin (Pont), also known as Tip49, encodes a member of the AAA+ ( A TPases A ssociated with Diverse Cellular A ctivities) superfamily and plays pivotal roles in cell proliferation and growth, yet its function in cell death has remained poorly understood. Here we performed a genetic screen for domin...

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Veröffentlicht in:	Cell death discovery 2018-07, Vol.4 (1), p.8-10, Article 74
Hauptverfasser:	Wang, Xingjun, Huang, Xirui, Wu, Chenxi, Xue, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136 631/208 Adenosine triphosphatase Apoptosis Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Cell death Cell proliferation Drosophila Epistasis Genetic screening Insects Kinases Life Sciences Phosphorylation Signal transduction Stem Cells Transcription
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