Cross-species systems analysis identifies gene networks differentially altered by sleep loss and depression

To understand the transcriptomic organization underlying sleep and affective function, we studied a population of (C57BL/6J × 129S1/SvImJ) F2 mice by measuring 283 affective and sleep phenotypes and profiling gene expression across four brain regions. We identified converging molecular bases for sle...

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Veröffentlicht in:	Science advances 2018-07, Vol.4 (7), p.eaat1294-eaat1294
Hauptverfasser:	Scarpa, Joseph R, Jiang, Peng, Gao, Vance D, Fitzpatrick, Karrie, Millstein, Joshua, Olker, Christopher, Gotter, Anthony, Winrow, Christopher J, Renger, John J, Kasarskis, Andrew, Turek, Fred W, Vitaterna, Martha H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressive Agents - therapeutic use Brain - metabolism Cerebral Cortex - metabolism Circadian Rhythm - genetics Depressive Disorder, Major - drug therapy Depressive Disorder, Major - genetics Depressive Disorder, Major - pathology Disease Models, Animal Gene Regulatory Networks Genotype Male Mice Mice, Inbred C57BL Neuroscience Phenotype Quantitative Trait Loci SciAdv r-articles Sleep Deprivation - drug therapy Sleep Deprivation - genetics Sleep Deprivation - pathology Systems Biology Transcriptome
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