Running on mixed fuel‐dual agonistic approach of GLP‐1 and GCG receptors leads to beneficial impact on body weight and blood glucose control: A comparative study between mice and non‐human primates

Aim We performed acute and chronic studies in healthy and diet‐induced obese animals using mouse‐specific or monkey‐specific dual GLP‐1R/GCGR agonists to investigate their effects on food intake, body weight, blood glucose control and insulin secretion. The selective GLP‐1R agonist liraglutide was u...

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Veröffentlicht in:	Diabetes, obesity & metabolism obesity & metabolism, 2018-08, Vol.20 (8), p.1836-1851
Hauptverfasser:	Elvert, Ralf, Herling, Andreas W., Bossart, Martin, Weiss, Tilo, Zhang, Baohong, Wenski, Pierre, Wandschneider, Jörn, Kleutsch, Sabrina, Butty, Uwe, Kannt, Aimo, Wagner, Michael, Haack, Torsten, Evers, Andreas, Dudda, Angela, Lorenz, Martin, Keil, Stefanie, Larsen, Philip J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Outbred Strains Appetite Depressants - administration & dosage Appetite Depressants - adverse effects Appetite Depressants - therapeutic use Blood glucose Body weight Body Weight - drug effects Body weight loss Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Diet Diet, High-Fat - adverse effects diet‐induced obesity Dose-Response Relationship, Drug Drug Therapy, Combination - adverse effects dual agonism, energy expenditure Energy expenditure Energy intake Energy Intake - drug effects Energy Metabolism - drug effects Female Food consumption Food intake GLP‐1 glucagon Glucagon-Like Peptide-1 Receptor - agonists Glucagon-Like Peptide-1 Receptor - genetics Glucagon-Like Peptide-1 Receptor - metabolism Glucose Glucose tolerance Hyperglycemia - prevention & control Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - adverse effects Hypoglycemic Agents - therapeutic use Insulin Insulin secretion Insulin Secretion - drug effects Macaca fascicularis Male Mice, Inbred C57BL Mice, Knockout mouse non‐human primates Obesity Obesity - blood Obesity - drug therapy Obesity - etiology Obesity - metabolism Original Oxidation Random Allocation Receptors, Glucagon - agonists Receptors, Glucagon - metabolism Secretion
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