Phasevarions of Bacterial Pathogens: Methylomics Sheds New Light on Old Enemies

A wide variety of bacterial pathogens express phase-variable DNA methyltransferases that control expression of multiple genes via epigenetic mechanisms. These randomly switching regulons – phasevarions – regulate genes involved in pathogenesis, host adaptation, and antibiotic resistance. Individual...

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Veröffentlicht in:	Trends in microbiology (Regular ed.) 2018-08, Vol.26 (8), p.715-726
Hauptverfasser:	Atack, John M., Tan, Aimee, Bakaletz, Lauren O., Jennings, Michael P., Seib, Kate L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotic resistance Antibiotics Bacteria Bacteria - enzymology Bacteria - genetics Bacteria - metabolism Deoxyribonucleic acid DNA DNA Methylation - genetics DNA methyltransferase DNA Modification Methylases - genetics DNA Modification Methylases - metabolism DNA sequencing DNA, Bacterial - metabolism Epigenesis, Genetic - genetics Epigenetics Feature recognition Gene expression Gene Expression Regulation, Bacterial - genetics Genes Genome, Bacterial - genetics Inverted Repeat Sequences - genetics methylome analysis methyltransferases microsatellite repeats Microsatellite Repeats - genetics Pathogenesis Pathogens phase variation phasevarion Proteomes regulon SMRT sequencing Switching
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