Systems Analyses Reveal Physiological Roles and Genetic Regulators of Liver Lipid Species

The genetics of individual lipid species and their relevance in disease is largely unresolved. We profiled a subset of storage, signaling, membrane, and mitochondrial liver lipids across 385 mice from 47 strains of the BXD mouse population fed chow or high-fat diet and integrated these data with com...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell systems 2018-06, Vol.6 (6), p.722-733.e6
Hauptverfasser:	Jha, Pooja, McDevitt, Molly T., Gupta, Rahul, Quiros, Pedro M., Williams, Evan G., Gariani, Karim, Sleiman, Maroun B., Diserens, Leo, Jochem, Adam, Ulbrich, Arne, Coon, Joshua J., Auwerx, Johan, Pagliarini, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BXD cardiolipin Diet, High-Fat fatty liver Female Gene Expression Regulation - genetics genetic reference population, GRP genetic variation Genome-Wide Association Study - methods genome-wide association study, GWAS Lipid Metabolism - physiology lipid species lipidomics Lipids - classification Lipids - genetics Liver - chemistry Liver - metabolism Male Mice Mice, Inbred C57BL Mice, Inbred DBA Non-alcoholic Fatty Liver Disease - genetics non-alcoholic fatty liver disease, NAFLD Phenotype Quantitative Trait Loci quantitative trait locus, QTL Reproducibility of Results Systems Analysis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!