Interleukin-6 Reduces β-Cell Oxidative Stress by Linking Autophagy With the Antioxidant Response

Production of reactive oxygen species (ROS) is a key instigator of β-cell dysfunction in diabetes. The pleiotropic cytokine interleukin 6 (IL-6) has previously been linked to β-cell autophagy but has not been studied in the context of β-cell antioxidant response. We used a combination of animal mode...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2018-08, Vol.67 (8), p.1576-1588
Hauptverfasser:	Marasco, Michelle R, Conteh, Abass M, Reissaus, Christopher A, Cupit, 5th, John E, Appleman, Evan M, Mirmira, Raghavendra G, Linnemann, Amelia K
Format:	Artikel
Sprache:	eng
Schlagworte:	Alloxan - toxicity Animal models Animals Antioxidants Apoptosis Autophagy Autophagy - drug effects Beta cells Biomarkers - metabolism Cell death Cell Line, Tumor Cell survival Cytokines Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - immunology Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Humans Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - immunology Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - pathology Interleukin 6 Interleukin-6 - genetics Interleukin-6 - metabolism Islet Studies Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Mitochondria Oxidative stress Oxidative Stress - drug effects Phagocytosis Random Allocation Rats Reactive oxygen species Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism Receptors, Interleukin-6 - agonists Receptors, Interleukin-6 - genetics Receptors, Interleukin-6 - metabolism Recombinant Proteins - metabolism Signal Transduction - drug effects Streptozocin Streptozocin - toxicity Tissue Banks Tissue Culture Techniques
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