Chronic Electrical Stimulation Promotes the Excitability and Plasticity of ESC-derived Neurons following Glutamate-induced Inhibition In vitro

Functional electrical stimulation (FES) is rapidly gaining traction as a therapeutic tool for mediating the repair and recovery of the injured central nervous system (CNS). However, the underlying mechanisms and impact of these stimulation paradigms at a molecular, cellular and network level remain...

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Veröffentlicht in:	Scientific reports 2018-07, Vol.8 (1), p.10957-16, Article 10957
Hauptverfasser:	Latchoumane, Charles-Francois V., Jackson, LaDonya, Sendi, Mohammad S. Eslampanah, Tehrani, Kayvan F., Mortensen, Luke J., Stice, Steven L., Ghovanloo, Maysam, Karumbaiah, Lohitash
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 14/63 38/77 631/136/142 631/378/3920 631/532/2182 9/30 96/100 Brain-derived neurotrophic factor Central nervous system Electrical stimuli Excitability Excitotoxicity Functional plasticity Gene expression Glutamic acid Glutamic acid receptors (ionotropic) Humanities and Social Sciences multidisciplinary N-Methyl-D-aspartic acid receptors Neuronal-glial interactions Neurons Plasticity Rab3A protein Science Science (multidisciplinary) Stem cells Traumatic brain injury
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