Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42

Inflammation is a major driver of tumor progression and metastasis, although the mechanisms by which proinflammatory cytokines drive metastatic invasion are unknown. Interleukin-6 (IL-6) is a potent proinflammatory cytokine that is elevated in individuals with pancreatic cancer (PDAC), is required f...

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Veröffentlicht in:	The Journal of biological chemistry 2018-07, Vol.293 (28), p.11143-11153
Hauptverfasser:	Razidlo, Gina L., Burton, Kevin M., McNiven, Mark A.
Format:	Artikel
Sprache:	eng
Schlagworte:	CDC42 cdc42 GTP-Binding Protein - genetics cdc42 GTP-Binding Protein - metabolism cell migration Cell Movement Cell Proliferation Gene Expression Regulation, Neoplastic Humans IL-6 interleukin 6 Interleukin-6 - pharmacology IQGAP1 JAK2 Janus kinase 2 Janus Kinase 2 - genetics Janus Kinase 2 - metabolism metastasis pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology rac GTP-Binding Proteins - genetics rac GTP-Binding Proteins - metabolism rhoA GTP-Binding Protein - genetics rhoA GTP-Binding Protein - metabolism Signal Transduction small GTPase STAT3 STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism Tumor Cells, Cultured
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