Rapid-Acting Antidepressants: Mechanistic Insights and Future Directions
Purpose of Review Ketamine produces rapid (within hours) antidepressant actions, even in patients considered treatment resistant, and even shows promise for suicidal ideation. Here, we review current research on the molecular and cellular mechanisms of ketamine and other novel rapid-acting antidepre...
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| Veröffentlicht in: | Current behavioral neuroscience reports 2018-03, Vol.5 (1), p.36-47 |
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| creator | Gerhard, Danielle M. Duman, Ronald S. |
| description | Purpose of Review
Ketamine produces rapid (within hours) antidepressant actions, even in patients considered treatment resistant, and even shows promise for suicidal ideation. Here, we review current research on the molecular and cellular mechanisms of ketamine and other novel rapid-acting antidepressants, and briefly explore gender differences in the pathophysiology and treatment of MDD.
Recent Findings
Ketamine, an NMDA receptor antagonist, increases BDNF release and synaptic connectivity, opposing the deficits caused by chronic stress and depression. Efforts are focused on the development of novel rapid agents that produce similar synaptic and rapid antidepressant actions, but without the side effects of ketamine. The impact of gender on the response to ketamine and other rapid-acting antidepressants is in early stages of investigation.
Summary
The discovery that ketamine produces rapid therapeutic actions for depression and suicidal ideation represents a major breakthrough and much needed alternative to currently available medications. However, novel fast acting agents with fewer side effects are needed, as well as elucidation of the efficacy of these rapid-acting antidepressants for depression in women. |
| doi_str_mv | 10.1007/s40473-018-0139-8 |
| format | Article |
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Ketamine produces rapid (within hours) antidepressant actions, even in patients considered treatment resistant, and even shows promise for suicidal ideation. Here, we review current research on the molecular and cellular mechanisms of ketamine and other novel rapid-acting antidepressants, and briefly explore gender differences in the pathophysiology and treatment of MDD.
Recent Findings
Ketamine, an NMDA receptor antagonist, increases BDNF release and synaptic connectivity, opposing the deficits caused by chronic stress and depression. Efforts are focused on the development of novel rapid agents that produce similar synaptic and rapid antidepressant actions, but without the side effects of ketamine. The impact of gender on the response to ketamine and other rapid-acting antidepressants is in early stages of investigation.
Summary
The discovery that ketamine produces rapid therapeutic actions for depression and suicidal ideation represents a major breakthrough and much needed alternative to currently available medications. However, novel fast acting agents with fewer side effects are needed, as well as elucidation of the efficacy of these rapid-acting antidepressants for depression in women.</description><identifier>ISSN: 2196-2979</identifier><identifier>EISSN: 2196-2979</identifier><identifier>DOI: 10.1007/s40473-018-0139-8</identifier><identifier>PMID: 30034992</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Antidepressants ; Anxiety ; Atrophy ; Behavior ; Behavioral Therapy ; Brain research ; Brain-derived neurotrophic factor ; Etiology ; Gender differences ; Medicine ; Medicine & Public Health ; Mental depression ; Metabolism ; Mood and Anxiety Disorders (C Harmer ; Neurology ; Pathophysiology ; Pediatrics ; Psychiatry ; Section Editor ; Stress ; Suicides & suicide attempts ; Topical Collection on Mood and Anxiety Disorders ; Womens health</subject><ispartof>Current behavioral neuroscience reports, 2018-03, Vol.5 (1), p.36-47</ispartof><rights>Springer International Publishing AG, part of Springer Nature 2018</rights><rights>Springer International Publishing AG, part of Springer Nature 2018.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3858-8f23abd4c71191cfd669c64a3959b091f20800c5c040668391edbec9af83dcf93</citedby><cites>FETCH-LOGICAL-c3858-8f23abd4c71191cfd669c64a3959b091f20800c5c040668391edbec9af83dcf93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40473-018-0139-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40473-018-0139-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30034992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gerhard, Danielle M.</creatorcontrib><creatorcontrib>Duman, Ronald S.</creatorcontrib><title>Rapid-Acting Antidepressants: Mechanistic Insights and Future Directions</title><title>Current behavioral neuroscience reports</title><addtitle>Curr Behav Neurosci Rep</addtitle><addtitle>Curr Behav Neurosci Rep</addtitle><description>Purpose of Review
Ketamine produces rapid (within hours) antidepressant actions, even in patients considered treatment resistant, and even shows promise for suicidal ideation. Here, we review current research on the molecular and cellular mechanisms of ketamine and other novel rapid-acting antidepressants, and briefly explore gender differences in the pathophysiology and treatment of MDD.
Recent Findings
Ketamine, an NMDA receptor antagonist, increases BDNF release and synaptic connectivity, opposing the deficits caused by chronic stress and depression. Efforts are focused on the development of novel rapid agents that produce similar synaptic and rapid antidepressant actions, but without the side effects of ketamine. The impact of gender on the response to ketamine and other rapid-acting antidepressants is in early stages of investigation.
Summary
The discovery that ketamine produces rapid therapeutic actions for depression and suicidal ideation represents a major breakthrough and much needed alternative to currently available medications. However, novel fast acting agents with fewer side effects are needed, as well as elucidation of the efficacy of these rapid-acting antidepressants for depression in women.</description><subject>Antidepressants</subject><subject>Anxiety</subject><subject>Atrophy</subject><subject>Behavior</subject><subject>Behavioral Therapy</subject><subject>Brain research</subject><subject>Brain-derived neurotrophic factor</subject><subject>Etiology</subject><subject>Gender differences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental depression</subject><subject>Metabolism</subject><subject>Mood and Anxiety Disorders (C Harmer</subject><subject>Neurology</subject><subject>Pathophysiology</subject><subject>Pediatrics</subject><subject>Psychiatry</subject><subject>Section Editor</subject><subject>Stress</subject><subject>Suicides & suicide attempts</subject><subject>Topical Collection on Mood and Anxiety Disorders</subject><subject>Womens health</subject><issn>2196-2979</issn><issn>2196-2979</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kVtLAzEQhYMoKuoP8EUWfPFldXLZ3cQHodRbQRFEn0OazbYpbbZmdgX_vSn1Dj6ECcx3zsxwCDmkcEoBqjMUICqeA5XpcZXLDbLLqCpzpiq1-eO_Qw4QZwBAqQBayG2ywwG4UIrtkttHs_R1PrCdD5NsEDpfu2V0iCZ0eJ7dOzs1wWPnbTYK6CfTDjMT6uy67_rosksfXZK2AffJVmPm6A4-6h55vr56Gt7mdw83o-HgLrdcFjKXDeNmXAtbUaqobeqyVLYUhqtCjUHRhoEEsIUFAWUpuaKuHjurTCN5bRvF98jF2nfZjxeuti500cz1MvqFiW-6NV7_7gQ_1ZP2VZdQ0IKvDE4-DGL70jvs9MKjdfO5Ca7tUTOoBGWsEjyhx3_QWdvHkM7TTKYFpSihShRdUza2iNE1X8tQ0Kuo9DoqnaLSq6i0TJqjn1d8KT6DSQBbA5haYeLi9-j_Xd8B-LKebg</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Gerhard, Danielle M.</creator><creator>Duman, Ronald S.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180301</creationdate><title>Rapid-Acting Antidepressants: Mechanistic Insights and Future Directions</title><author>Gerhard, Danielle M. ; Duman, Ronald S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3858-8f23abd4c71191cfd669c64a3959b091f20800c5c040668391edbec9af83dcf93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Antidepressants</topic><topic>Anxiety</topic><topic>Atrophy</topic><topic>Behavior</topic><topic>Behavioral Therapy</topic><topic>Brain research</topic><topic>Brain-derived neurotrophic factor</topic><topic>Etiology</topic><topic>Gender differences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental depression</topic><topic>Metabolism</topic><topic>Mood and Anxiety Disorders (C Harmer</topic><topic>Neurology</topic><topic>Pathophysiology</topic><topic>Pediatrics</topic><topic>Psychiatry</topic><topic>Section Editor</topic><topic>Stress</topic><topic>Suicides & suicide attempts</topic><topic>Topical Collection on Mood and Anxiety Disorders</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gerhard, Danielle M.</creatorcontrib><creatorcontrib>Duman, Ronald S.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Current behavioral neuroscience reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gerhard, Danielle M.</au><au>Duman, Ronald S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid-Acting Antidepressants: Mechanistic Insights and Future Directions</atitle><jtitle>Current behavioral neuroscience reports</jtitle><stitle>Curr Behav Neurosci Rep</stitle><addtitle>Curr Behav Neurosci Rep</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>5</volume><issue>1</issue><spage>36</spage><epage>47</epage><pages>36-47</pages><issn>2196-2979</issn><eissn>2196-2979</eissn><abstract>Purpose of Review
Ketamine produces rapid (within hours) antidepressant actions, even in patients considered treatment resistant, and even shows promise for suicidal ideation. Here, we review current research on the molecular and cellular mechanisms of ketamine and other novel rapid-acting antidepressants, and briefly explore gender differences in the pathophysiology and treatment of MDD.
Recent Findings
Ketamine, an NMDA receptor antagonist, increases BDNF release and synaptic connectivity, opposing the deficits caused by chronic stress and depression. Efforts are focused on the development of novel rapid agents that produce similar synaptic and rapid antidepressant actions, but without the side effects of ketamine. The impact of gender on the response to ketamine and other rapid-acting antidepressants is in early stages of investigation.
Summary
The discovery that ketamine produces rapid therapeutic actions for depression and suicidal ideation represents a major breakthrough and much needed alternative to currently available medications. However, novel fast acting agents with fewer side effects are needed, as well as elucidation of the efficacy of these rapid-acting antidepressants for depression in women.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>30034992</pmid><doi>10.1007/s40473-018-0139-8</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Current behavioral neuroscience reports, 2018-03, Vol.5 (1), p.36-47 |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Antidepressants Anxiety Atrophy Behavior Behavioral Therapy Brain research Brain-derived neurotrophic factor Etiology Gender differences Medicine Medicine & Public Health Mental depression Metabolism Mood and Anxiety Disorders (C Harmer Neurology Pathophysiology Pediatrics Psychiatry Section Editor Stress Suicides & suicide attempts Topical Collection on Mood and Anxiety Disorders Womens health |
| title | Rapid-Acting Antidepressants: Mechanistic Insights and Future Directions |
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